Preparation of a novel asymmetric wettable chitosan-based sponge and its role in promoting chronic wound healing

Xia, Guixue; Zhai, Dongqing; Sun, Yue; Hou, Lin; Guo, Xiaofan; Wang, Lixia; Z, Li; Wang, Feng

doi:10.1016/j.carbpol.2019.115296

Cited by 111 publications

(71 citation statements)

References 64 publications

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“…The porosity of nanofibrous films was determined according to the reported method. 33 Briefly, the nanofibrous films were immersed in absolute ethanol. In order to overcome the effect of interface energy, absolute ethanol was filled into the material interior through a vacuuming procedure until it was saturated.…”

Section: Porosity Measurementmentioning

confidence: 99%

“…The in vitro degradation of TOLs-CS/PEO nanofibrous films was assessed by the loss weight method. 33 The dried electrospun samples were cut into square pieces of 15 mm and weighed. They were immersed into the PBS solution (pH = 7.4) containing 50 mg/ml of lysozyme enzyme (15,000 U/mg) at 37 C for a week.…”

Section: In Vitro Degradationmentioning

confidence: 99%

“…WVTR is used to determine the ability to control water loss and moisture microenvironment at the wound site during wound healing of the dressings, depending on the porosity, pore structure, physicochemical properties of the pore wall in wound dressing. 29,33 The presence of pores in the dressing structure was capable of preserving water and allowing appropriate control of the microenvironment moisture for the suitable breathability and effective protection of lesion through preventing external contamination and dehydration. 39,40 Therefore, the ideal wound dressing should own proper permeability.…”

Section: Water Vapor Transmission Ratementioning

confidence: 99%

“…It had been reported that CS sponge with large porosity could uptake more solvent molecules and accelerate the degradation of itself, while the slower degradation rate of CS sponges might be attributed to its more compact sponge matrix. 33 The paradox might be illustrated that the high TOLs content of nanofibrous films led to the weak intermolecular force and loose matrix to reverse the low degradation rate caused by low porosity. Moreover, the results also showed that TOLs content had little effect on lysozyme activity.…”

Section: In Vitro Hemostasis Capability and In Vitro Degradationmentioning

confidence: 99%

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Terpinen‐4‐ol liposomes‐incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds

Yan

Tang

et al. 2020

J of Applied Polymer Sci

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Chronic wounds are susceptible to infection and difficult to heal due to the complex healing process and terrible microenvironment. In order to overcome this problem, TOLs‐CS/PEO nanofibrous film was successfully electrospun. The 6%(v/v) TOLs incorporation into CS/PEO nanofibrous film could improve the morphology and structure of nanofibers, weaken the interactions among macromolecules and rebalance the relationship between hydrophilicity and hydrophobicity of pore surface. Water vapor transmission rate and simulated tissue fluid absorption of films were optimized to reach 2193 g m−2 d−1 and 1676% so that to obtain the excellent moisture retention. The Young's modulus and elongation at break of films in wet state were 114.69 kPa and 72.04%, respectively, causing the mechanical characteristics similar to human skin. The film could effectively block more than 98% of bacteria and inhibit bacteria growth besides possessing procoagulant property and suitable biodegradability. These findings demonstrate that TOLs‐CS/PEO nanofibrous film can construct a microenvironment suitable for wound healing.

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Section: Porosity Measurementmentioning

confidence: 99%

Section: In Vitro Degradationmentioning

confidence: 99%

Section: Water Vapor Transmission Ratementioning

confidence: 99%

Section: In Vitro Hemostasis Capability and In Vitro Degradationmentioning

confidence: 99%

See 2 more Smart Citations

Terpinen‐4‐ol liposomes‐incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds

Yan

Tang

et al. 2020

J of Applied Polymer Sci

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“…Skin, as the largest and outermost organ of human body, provides the barrier between the internal organism and external environment for protecting body from invasion of pathogens, as well as preventing water loss [1,2]. It is estimated that approximately 312.9 million people throughout the world suffer from the surgically-induced wounds annually, and 76 million people undergo the wounds caused by complications of diabetes, obesity, cardiovascular disease and so on [3].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibrous Materials for Wound Healing

et al. 2020

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Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired. Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area, better mimicry of native extracellular matrix, adjustable waterproofness and breathability, and programmable drug delivery process. In this review article, we begin with a discussion of wound healing process and current commercial wound dressing materials. Then, we emphasize on electrospun nanofibrous materials for wound dressing, covering the efforts for controlling fiber alignment and morphology, constructing 3D scaffolds, developing waterproof-breathable membrane, governing drug delivery performance, and regulating stem cell behavior. Finally, we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings.

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Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing

Zheng

Tong

Zhang

et al. 2021

Adv Funct Materials

162

106

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Real‐time monitoring of wound healing remains a major challenge in clinical tissue regeneration, calling the need for the development of biomaterial‐guided on‐site monitoring wound healing technology. In this study, multifunctional double colorimetry‐integrated polyacrylamide‐quaternary ammonium chitosan‐carbon quantum dots (CQDs)‐phenol red hydrogels are presented, aiming to simultaneously detect the wound pH level, reduce bacterial infection, and promote wound healing. The hybridization of CQDs and pH indicator (phenol red) with the hydrogels enables their high responsiveness, reversibility, and accurate indication of pH variability to reflect the dynamic wound status in the context of both ultraviolet and visible light. Furthermore, these visual images can be collected by smartphones and converted into on‐site wound pH signals, allowing for a real‐time evaluation of the wound dynamic conditions in a remote approach. Notably, the hydrogels exhibit excellent hemostatic and adhesive properties, maintain sufficient wound moisture, and promote wound healing via their high antibacterial activity (against Staphylococcus Aureus, and Escherichia Coli) and skin repair function. Overall, the resulting hydrogels have high potential as a novel smart and flexible wound dressing platform for theranostic skin regeneration.

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Preparation of a novel asymmetric wettable chitosan-based sponge and its role in promoting chronic wound healing

Cited by 111 publications

References 64 publications

Terpinen‐4‐ol liposomes‐incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds

Terpinen‐4‐ol liposomes‐incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds

Electrospun Nanofibrous Materials for Wound Healing

Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing

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