Preparation and properties of 7α-formamido cephalosporins

Guest, Angela W.; Branch, Clive L.; Finch, Stephen C.; Kaura, Arun C.; Milner, Peter H.; Pearson, Michael J.; Ponsford, Roger J.; Smale, T. C.

doi:10.1039/p19870000045

Cited by 20 publications

(1 citation statement)

References 8 publications

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“…Compounds 8 a and 8 b (as a mixture in a ratio of 1: Epoxides 6 a and 6 b [26] (as a mixture in a ratio of 1:15.1), 7 a and 7 b [27] (as a mixture in a ratio of 1:10.4), 9 a and 9 b [28] (as a mixture in a ratio of 1:8.8), 10 a and 10 b [27] (as a mixture in a ratio of 1:11.6), 12 a, [29] [35] and 21 b [36] have spectroscopic data which are identical with those reported in literature.…”

Section: Methodsmentioning

confidence: 99%

Highly β‐Selective Epoxidation of Δ ⁵ ‐Unsaturated Steroids Catalyzed by Ketones

Yang

Jiao

2000

Chemistry A European J

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A general catalytic and environmentally friendly method for beta-epoxidation of delta5-unsaturated steroids has been developed, which uses ketones as the catalysts and Oxone as the terminal oxidant. A whole range of delta5-unsaturated steroids, which bear different functional groups such as hydroxyl, carbonyl, acetyl, or ketal, as well as different side chains, were conveniently converted to the corresponding synthetically and biologically interesting 5beta,5beta-epoxides with excellent beta-selectivities and high yields.

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Section: Methodsmentioning

confidence: 99%

Highly β‐Selective Epoxidation of Δ ⁵ ‐Unsaturated Steroids Catalyzed by Ketones

Yang

Jiao

2000

Chemistry A European J

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Cephalosporins

Roberts¹

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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CEPHALOSPORINSThe cephalosporins, a subgroup of β-lactam antibiotics, consist of a 4-membered lactam ring fused through the nitrogen and the adjacent tetrahedral carbon atom to a second heterocycle forming a 6-membered dihydrothiazine ring. Other structural features common to all the cephalosporins are a carboxyl group on the dihydrothiazine ring on the carbon next to the ring nitrogen and a functionalized amino group on C-7, the carbon of the β-lactam ring opposite the nitrogen. These features are evidenced in 7-aminocephalosporanic acid [957-68-6] (7-ACA), C 10 H 12 N 2 O 5 S 1. Cephalosporins, like all β-lactam antibiotics, exert their antibacterial effect by interfering with the synthesis of the bacterial cell wall. These antibiotics tend to be "irreversible" inhibitors of cell wall biosynthesis and they are usually bactericidal at concentrations close to their bacteriostatic levels. Cephalosporins are widely used for treating bacterial infections. They are highly effective antibiotics and have low toxicity.

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β‐Lactam Antibiotics

Andreotti

Biondi

Modugno

2003

Burger's Medicinal Chemistry and Drug Discovery

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This chapter reviews the history of β‐lactams from the discovery of penicillin in 1928 to the more recently studied and the current trends in the field. The most relevant aspects related to the mechanism of action of β‐lactams are covered, and the various mechanisms of resistance to currently available β‐lactams that bacteria have adopted since the introduction of penicillin are described. A classification of β‐lactamases and their relevance in clinics is also provided. Applications of β‐lactams both in the hospital and in the community are reported, with particular attention to their pharmacokinetic properties, related side effects, and their therapeutic indications. The history and discovery of β‐lactams are described and all major classes are covered: penicillins, cephalosporins, oxacephems, carbacephems, penems, monobactams and nocardicins, carbapenems and trinems, classical (e.g., clavulanic acid, sulbactam, tazobactam), and the more recently disclosed β‐lactamase inhibitors. Several aspects related to the most recent developments in β‐lactams are also covered: new molecules active against difficult Gram‐positive strains or endowed with an antibacterial broad spectrum of action; potent orally active β‐lactams; injectable β‐lactams; and β‐lactamase inhibitors. The chapter concludes with a continuing analysis of the industry‐driven trends and the most recent new application of β‐lactams as inhibitors of protein export in bacteria. Finally, a few very interesting Web addresses and a comprehensive reference list are also provided.

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Preparation and properties of 7α-formamido cephalosporins

Cited by 20 publications

References 8 publications

Highly β‐Selective Epoxidation of Δ ⁵ ‐Unsaturated Steroids Catalyzed by Ketones

Highly β‐Selective Epoxidation of Δ ⁵ ‐Unsaturated Steroids Catalyzed by Ketones

Cephalosporins

β‐Lactam Antibiotics

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Preparation and properties of 7α-formamido cephalosporins

Cited by 20 publications

References 8 publications

Highly β‐Selective Epoxidation of Δ 5 ‐Unsaturated Steroids Catalyzed by Ketones

Highly β‐Selective Epoxidation of Δ 5 ‐Unsaturated Steroids Catalyzed by Ketones

Cephalosporins

β‐Lactam Antibiotics

Contact Info

Product

Resources

About

Highly β‐Selective Epoxidation of Δ ⁵ ‐Unsaturated Steroids Catalyzed by Ketones

Highly β‐Selective Epoxidation of Δ ⁵ ‐Unsaturated Steroids Catalyzed by Ketones