Preparation and photodynamic antibacterial/anticancer effects of ultralong-lifetime room-temperature phosphorescent N-doped carbon dots

Miao, Yanming; Zhang, Xinhao; Li, Jinyao; Yang, Weidong; Huang, Xiaomin; Lv, Jinzhi

doi:10.1039/d2ra02251f

Cited by 13 publications

(10 citation statements)

References 31 publications

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“…As shown in Figure 1c, it can be seen that CDs show broad FTIR transmission from around 2500−3500 cm −1 , which might be attributed to the stretching vibration of several groups, including amino (−NH 2 ), methylene (−CH 2 −), and hydroxyl (−OH) groups. 28,29 The sharp peaks at 2921 and 2853 cm −1 correspond to sp 3 C−H bond vibrations and suggest the formation of a graphitic carbon core in the CDs. The absorbance peaks at 1743 and 903 cm −1 , which are associated with C�O and C�C bonds, further confirm the presence of a p conjugation system as the core structures of CDs.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Machine Learning-Guided Synthesis of Room-Temperature Phosphorescent Carbon Dots for Enhanced Phosphorescence Lifetime and Information Encryption

Muyassiroh,

Permatasari,

Hirano

et al. 2024

ACS Appl. Nano Mater.

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Room-temperature phosphorescent (RTP) carbon dots (CDs) have been increasingly used in many applications, including anticounterfeiting and information encryption. However, synthesizing RTP CDs with a specific average lifetime of phosphorescence remains a formidable challenge. A breakthrough is needed in formulating the synthesis process to find a suitable synthesis formulation to produce CDs with an optimal lifetime of phosphorescence. Machine learning (ML) has recently been successfully used for guiding material synthesis and offering insight into the prediction, optimization, and acceleration of the CDs' synthesis process. A regression ML model on microwave-assisted CD synthesis is established to reveal the relationship between various synthesis parameters and enhance the average lifetime of phosphorescence of CDs in the solid-state phase. RTP CDs exhibit a blue emission when irradiating with UV and a green emission afterglow after the UV is turned off. These green emissions can last for 7 s, are easily observed by the naked eye, and show an ultralong phosphorescence lifetime of up to 1.6 s. Moreover, designed and guided by ML, this afterglow feature was explored to achieve multilevel anticounterfeiting and information encryption to encrypt and decrypt secret information in dynamic time-dependent displays. Our results provide a strategy for synthesizing RTP CDs with a specific lifetime and extending their application scope to high-level information security.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Machine Learning-Guided Synthesis of Room-Temperature Phosphorescent Carbon Dots for Enhanced Phosphorescence Lifetime and Information Encryption

Muyassiroh,

Permatasari,

Hirano

et al. 2024

ACS Appl. Nano Mater.

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“…Similar phenomena and antibacterial mechanisms have been also found in the other reports. [59][60][61] Especially in Miao's group's work, the obtained CNDs possessed ultralonglifetime room-temperature phosphorescent. 57 Their extremely long T 1 exciton lifetime and the increase of collision time with O 2 improved the probability of energy transfer, leading to a tremendous increase in the production of 1 O 2 , thus showing an excellent photodynamic sterilization effect.…”

Section: Rosmentioning

confidence: 98%

Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation

Fang,

Lin,

Zheng

et al. 2023

J. Mater. Chem. B

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“…N-doping is another approach promoted in the literature for the synthesis of antibacterial CDs. ,,− While a general theory connecting N-doping and antibacterial activities has not been developed, followers of this approach swarm. A possible reason is that N-doping can be easily achieved as long as a N-containing starting material is used in the synthesis of CDs .…”

Section: Introductionmentioning

confidence: 99%

Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging

Huang,

Hsu,

Wang

et al. 2023

ACS Appl. Nano Mater.

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Carbon nanodots (CDs) are known to inhibit the growth of bacteria, and a developing trend is observed in the literature that attributes such activities specifically to photoactivation, N-doping, and/or surface charge. In this study, we demonstrate that CDs can inhibit bacteria growth as well without these predispositions. Using the minimum inhibitory concentration and minimum bactericidal concentration protocols, we study, without irradiation, the inhibitory activities of CDs that are low in N-content and surface charge, against Escherichia coli O157:H7, Salmonella enterica ser. Typhimurium, and Staphylococcus aureus. The CDs are further tested in a zebrafish model for acute toxicity. These CDs exhibit antibacterial activities comparable to those of previously reported CDs with IC 50 s of 0.66, 0.75, and 1.00 mg/mL for the three bacteria, respectively. They are also shown to have manageable acute toxicity for safe applications in areas such as antibacterial wound dressing and food packaging. These results indicate that our knowledge base of the required characteristics for CDs to be antibacterial is incomprehensive despite the burgeoning of studies in this area, and the biological pathways leading to such activities are much more diverse than the current literature has suggested.

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Preparation and photodynamic antibacterial/anticancer effects of ultralong-lifetime room-temperature phosphorescent N-doped carbon dots

Abstract: The URTP CNDs largely extends the collision time between T1 state exciton and O2, which improve quantum yield of singlet oxygen (1O2) in solutions, facilitating the photodynamic antibacterial and anticancer effects.

Cited by 13 publications

References 31 publications

Machine Learning-Guided Synthesis of Room-Temperature Phosphorescent Carbon Dots for Enhanced Phosphorescence Lifetime and Information Encryption

Machine Learning-Guided Synthesis of Room-Temperature Phosphorescent Carbon Dots for Enhanced Phosphorescence Lifetime and Information Encryption

Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation

Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging

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