Preparation and characterization of thermosensitive pluronic F127-b-poly(ɛ-caprolactone) mixed micelles

Zhou, Qi; Zhang, Zhao; Chen, Tao; Guo, Xing; Zhou, Shaobing

doi:10.1016/j.colsurfb.2011.03.013

Cited by 75 publications

(60 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To determine the critical micelle concentration (CMC) values of both mPEG–CL X copolymers and mPEG–CL X ‐FITC, a fluorescence‐based method was used according to our previous report 41…”

Section: Methodsmentioning

confidence: 99%

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

Zhang

et al. 2013

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

Fluorescein isothiocyanate (FITC), a fluorescent probe, is coupled to amphiphilic monomethoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) copolymers. FITC-labeled mPEG-PCL copolymers self-assemble into micelles through the solvent evaporation method. The cellular internalization is examined using fluorescence microscopy on incubation of NIH-3T3 fibroblasts with micelles or free FITC solution. The effect of the hydrophilic/hydrophobic ratio on the endocytosis mechanisms is evaluated by fluorescence microscopy on culturing of human hepatoblastoma cells and human umbilical vein endothelial cells, individually, mixed with the micelles holding the same parameters including micelle size, shape, and surface charges.

show abstract

Section: Methodsmentioning

confidence: 99%

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

Zhang

et al. 2013

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…[17][18] For pharmaceutical applications, biodegradable and biocompatible amphiphilic copolymers are usually used to prepare micelles with relatively high stability because of their low critical micelle concentration (CMC) values. [19][20][21] Commonly, poly(ethylene glycol) (PEG) is selected as the hydrophilic segment. 22 Among hydrophobic segments, polyesters such as poly(d, l-lactide-co-glycolide) (PLGA), 23 polyglycolide (PGA) and polycaprolactone (PCL) have received the most attention.…”

Section: Introductionmentioning

confidence: 99%

Micelles Based on Methoxy Poly(Ethylene Glycol)Cholesterol Conjugate for Controlled and Targeted Drug Delivery of a Poorly Water Soluble Drug

He²,

Yu³

et al. 2012

Journal of Biomedical Nanotechnology

View full text Add to dashboard Cite

In this study, quercetin (QC) with cancer chemoprevention effect and anticancer potential was loaded into polymeric micelles of methoxy poly(ethylene glycol)-cholesterol conjugate (mPEG-Chol) in order to increase its water solubility. MPEG-Chol with lower critical micelle concentration (CMC) value (4 0 × 10 −7 M ∼ 13 × 10 −7 M) was firstly synthesized involving two steps of chemical modification on cholesterol by esterification, and then QC was incorporated into mPEG-Chol micelles by self-assembly method. After the process parameters were optimized, QC-loaded micelles had higher drug loading (3.66%) and entrapment efficiency (93.51%) and nano-sized diameter (116 nm). DSC analysis demonstrated that QC had been incorporated non-covalently into the micelles and existed as an amorphous state or a solid solution in the polymeric matrix. The freeze-dried formulation with addition of 1% (w/v) mannitol as cryoprotectant was successfully developed for the long-term storage of QC-loaded micelles. Compared to free QC, QC-loaded micelles could release QC more slowly. Moreover, the release of QC from micelles was slightly faster in PBS at pH 5 than that in PBS at pH 7.4, which implied that QC-loaded micelles might be pH-sensitive and thereby selectively deliver QC to tumor tissue with unwanted side effects. Therefore, mPEG-Chol was a promising micellar vector for the controlled and targeted drug delivery of QC to tumor and QCloaded micelles were also worth being further investigated as a potential formulation for cancer chemoprevention and treatment.

show abstract

“…This reaction is generally carried out in the presence of an alkaline catalyst such as sodium hydroxide which is then neutralised and removed 20 . Pluronics® are semi-crystalline in nature where, PEO units impart crystallinity to the polymer 21,22 . The physical properties of Pluronics® are dependent upon their molecular weight and PPO-PEO ratios.…”

Section: Introduction-mentioning

confidence: 99%

Effect of Pressure on the Melting Point of Pluronics in Pressurized Carbon Dioxide

Bhomia

Trivedi

Mitchell

et al. 2014

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Abstract-The melting points of Pluronic® F-77, F-127, F-68, F-38 and F-108 were investigated in pressurised CO 2 between a pressure range of (2.0 to 50.0) MPa. Unprocessed and CO 2 -processed Pluronic® samples were analysed by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). A melting point depression in the range of (18.1± 0.5 to 19.3± 0.3) K was observed for all Pluronics® studied in this work. The melting point of Pluronics® in pressurised CO 2 was found to be independent of their molecular weight and poly (propylene oxide) [PPO] content. Analysis by DSC and PXRD revealed that CO 2 processing had no impact on the morphology of Pluronics®.

show abstract

Preparation and characterization of thermosensitive pluronic F127-b-poly(ɛ-caprolactone) mixed micelles

Cited by 75 publications

References 44 publications

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

Micelles Based on Methoxy Poly(Ethylene Glycol)Cholesterol Conjugate for Controlled and Targeted Drug Delivery of a Poorly Water Soluble Drug

Effect of Pressure on the Melting Point of Pluronics in Pressurized Carbon Dioxide

Contact Info

Product

Resources

About