Preparation and Characterization of Poly(vinyl alcohol) Based Scaffold Using Improved Salt Leaching Method

Sadanand, Jinna.; Kumar, Amitesh; Pramanik, Krishna

doi:10.1166/jbt.2012.1034

Cited by 2 publications

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“…successfully made porous scaffolds for bone regeneration via scCO 2 foaming and particle leaching techniques. In addition to thermoplastic zein chosen as the porogen, paraffin spheres, sugar particles, and inorganic salt particles, especially sodium chloride (NaCl), are commonly used by researchers due to their facile sourcing and easy leaching . As for NaCl porogen, NaCl particles with the size of several hundred micrometer or about 5 μm were used to prepare scaffolds individually.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of bimodal porous PLGA scaffolds by supercritical CO₂ foaming/particle leaching technique

Xin

Liu

Chen

et al. 2016

J of Applied Polymer Sci

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Specific pore structure is a vital essential for scaffolds applied in tissue engineering. In this article, poly(lactide-co-glycolide) (PLGA) scaffolds with a bimodal pore structure including macropores and micropores to facilitate nutrient transfer and cell adhesion were fabricated by combining supercritical CO 2 (scCO 2 ) foaming with particle leaching technique. Three kinds of NaCl particles with different scales (i.e., 100-250, <75, <10 lm) were used as porogens, respectively. In particular, heterogeneous nucleation occurred to modify scCO 2 foaming/particle leaching process when NaCl submicron particles (<10 lm) were used as porogens. The observation of PLGA scaffolds gave a formation of micropores (pore size <10 lm) in the cellular walls of macropores (pore size around 100-300 lm) to present a bimodal pore structure. With different mass fractions of NaCl introduced, the porosity of PLGA scaffolds ranged from 68.4 6 1.4 to 88.7 6 0.4% for three NaCl porogens. The results of SEM, EDS, and in vitro cytotoxicity test of PLGA scaffolds showed that they had uniform structures and were compatible for cell proliferation with no toxicity. This novel scCO 2 foaming/particle leaching method was promising in tissue engineering due to its ability to fabricate scaffolds with precise pore structure and high porosity.

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Section: Introductionmentioning

confidence: 99%

Fabrication of bimodal porous PLGA scaffolds by supercritical CO₂ foaming/particle leaching technique

Xin

Liu

Chen

et al. 2016

J of Applied Polymer Sci

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Composite scaffolds of nano calcium deficient hydroxyapatite/multi-(amino acid) copolymer for bone tissue regeneration

Yang

Dong

et al. 2014

J Mater Sci: Mater Med

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In this study, nano calcium deficient hydroxyapatite (n-DA)/multi-(amino acid) copolymer composite scaffolds were prepared by injection molding foaming method using calcium sulphate dihydrate as a foaming agent. The composite scaffolds showed well interconnected macropores with the pore size of ranging from 100 to 600 μm, porosity of 81 % and compressive strength of 12 MPa, and the compressive strength obviously affected by the porosity. The composite scaffolds could be slowly degraded in phosphate buffered solution (PBS), which lost its initial weight of 61 w % after immersion into PBS for 12 weeks, and the porosity significantly affected the degradability of the scaffolds. Moreover, it was found that the composite scaffolds could promote the MG-63 cells growth and proliferation, and enhance its alkaline phosphatase activity. The implantation of the scaffolds into the femoral bone of rabbits confirmed that the composite scaffolds were biocompatibitive, degradable, and osteoconductive in vivo.

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Preparation and Characterization of Poly(vinyl alcohol) Based Scaffold Using Improved Salt Leaching Method

Cited by 2 publications

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Fabrication of bimodal porous PLGA scaffolds by supercritical CO₂ foaming/particle leaching technique

Fabrication of bimodal porous PLGA scaffolds by supercritical CO₂ foaming/particle leaching technique

Composite scaffolds of nano calcium deficient hydroxyapatite/multi-(amino acid) copolymer for bone tissue regeneration

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Preparation and Characterization of Poly(vinyl alcohol) Based Scaffold Using Improved Salt Leaching Method

Cited by 2 publications

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Fabrication of bimodal porous PLGA scaffolds by supercritical CO2 foaming/particle leaching technique

Fabrication of bimodal porous PLGA scaffolds by supercritical CO2 foaming/particle leaching technique

Composite scaffolds of nano calcium deficient hydroxyapatite/multi-(amino acid) copolymer for bone tissue regeneration

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Fabrication of bimodal porous PLGA scaffolds by supercritical CO₂ foaming/particle leaching technique

Fabrication of bimodal porous PLGA scaffolds by supercritical CO₂ foaming/particle leaching technique