Preparation and characterization of pH‐sensitive carboxymethyl cellulose‐based hydrogels for controlled drug delivery

Pourkhatoun, Mina; Kalantari, Maryam; Kamyabi, Ata

doi:10.1002/pi.6382

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…In the future, the application prospect and scope of CMC gels can be considered from the following two aspects: Intelligent and responsive CMC gels should be developed further. Using the tumor microenvironment or external stimulation [ 68 ], the time and space control of chemotherapy drugs could be achieved easily, which can not only reduce the side effects but also achieve real-time tumor monitoring. CMC gels could be modified to adapt to gene therapy.…”

Section: Discussionmentioning

confidence: 99%

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Synthesis and Applications of Carboxymethyl Cellulose Hydrogels

Zhang

Liu

et al. 2022

Gels

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Hydrogels are basic materials widely used in various fields, especially in biological engineering and medical imaging. Hydrogels consist of a hydrophilic three-dimensional polymer network that rapidly expands in water and can hold a large volume of water in its swelling state without dissolving. These characteristics have rendered hydrogels the material of choice in drug delivery applications. In particular, carboxymethyl cellulose (CMC) hydrogels have attracted considerable research attention for the development of safe drug delivery carriers because of their non-toxicity, good biodegradability, good biocompatibility and low immunogenicity. Aiming to inspire future research in this field, this review focuses on the current preparation methods and applications of CMC gels and highlights future lines of research for the further development of diverse applications.

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Section: Discussionmentioning

confidence: 99%

“…Intelligent and responsive CMC gels should be developed further. Using the tumor microenvironment or external stimulation [ 68 ], the time and space control of chemotherapy drugs could be achieved easily, which can not only reduce the side effects but also achieve real-time tumor monitoring.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Applications of Carboxymethyl Cellulose Hydrogels

Zhang

Liu

et al. 2022

Gels

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“…Sodium carboxymethylcellulose (Na-CMC) is one of the most manufactured ethers of cellulose and is used in a variety of industries, including oil-gas, construction, textiles, agriculture, pharmaceuticals and paper industries (Behra et al 2019). Its purified grades as additives are widely used in cosmetic products, food (Yuldoshov, Goyibnazarov et al 2020), medicine for making tablets (Shah et al 1981), medicinal films (Yunusov et al 2021) and drug delivery (Pourkhatoun et al 2022) and can also be used in ore beneficiation (Kumar et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Impact of cellulose supramolecular structure on its carboxymethylation reaction activity

Yuldoshov,

Yunusov,

Goyipnazarov

et al. 2024

Preprint

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The reaction activity of cellulose samples is determined according to their supramolecular structure, especially the degree of crystallinity. The carboxymethylation reaction kinetics of cotton cellulose (CC), powder cellulose (PC) and microcrystalline cellulose (MCC), with different degrees of crystallinity, were studied by the solid-phase method and in an ethanol-water solution medium. In the row of CC, MCC, and PC with different supramolecular structures, it was found that with decreasing crystallinity degree of the raw materials, during carboxymethylation by the solid-phase method and in an ethanol-water solution medium, the degree of substitution (DS) of sodium carboxymethylcellulose (Na-CMC) increased. In this row the activation energy values of the carboxymethylation reaction of CC, MCC, and PC were 31.12, 19.75, and 15.72 kJ/mol, respectively, by the solid-phase method. Furthermore, the activation energies of the carboxymethylation reaction of CC, MCC, and PC were 59.95, 26.15, and 23.68 kJ/mol, respectively, in an ethanol-water solution medium. Decreasing activation energies led to an increase in the reaction activity, which, after CC, MCC, and PC carboxymethylation, the DS of Na-CMC reached 0.61, 0.80, and 0.87, respectively, using the solid-phase method. In an ethanol solution medium, the DS values of Na-CMC reached 0.86, 1.04, and 1.24 after carboxymethylation of the CC, MCC, and PC, respectively.

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“…[10][11][12] Because of these properties, there has been a particular interest in hydrogels based on polysaccharides like alginate, carrageenan, chitosan, cellulose, and starch. [13][14][15][16][17][18] Carboxymethyl cellulose (CMC) is a chemically modified cellulose derivative that is created by bonding the hydroxyl group of the glucopyranose unites with the carboxymethyl groups. CMCs are one of the most common industrially available ethers of cellulose that could form various amorphous polymers with different molecular weights and degrees of carboxymethylation.…”

Section: Introductionmentioning

confidence: 99%

The effects of degassing, neutralization, and dewatering on the CMC-g-poly (acrylic acid-co-methacrylic acid) hydrogel

Pourkhatoun

Kalantari

Kamyabi

2023

Polymers from Renewable Resources

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CMC-g-poly (acrylic acid-co-methacrylic acid) hydrogel was prepared by free radical polymerization of acrylic acid (AA) and methacrylic acid (MAA) onto carboxymethyl cellulose (CMC) backbone using ammonium persulfate (APS) as an initiator and N, N′-methylene bisacrylamide (MBA) as a crosslinker. For investigating the effects of before and after treatments of the hydrogel on the swelling equilibrium, gel fraction, and weight loss, 3 sets of experiments with 5 samples were designed and the effect of degassing (using N2), neutralization with NaOH 1 M, and two stages of dewatering with acetone and ethanol was studied. The results confirmed the positive effects of all the after-treatment stages. The final data indicate that sample (v) with N2 as reaction atmosphere, one neutralization stage, and two dewatering stages exhibit a maximum swelling of 167 g/g, maximum gel fraction of 61.4%, and also maximum weight loss of 38.6%. These outcomes show that these treatments exhibit hydrogel with a good swelling ratio which is desirable in smart delivery systems, healthcare, and biomedical applications. The optimized sample was characterized by FT-IR, SEM, and TGA too.

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Preparation and characterization of pH‐sensitive carboxymethyl cellulose‐based hydrogels for controlled drug delivery

Cited by 8 publications

References 31 publications

Synthesis and Applications of Carboxymethyl Cellulose Hydrogels

Synthesis and Applications of Carboxymethyl Cellulose Hydrogels

Impact of cellulose supramolecular structure on its carboxymethylation reaction activity

The effects of degassing, neutralization, and dewatering on the CMC-g-poly (acrylic acid-co-methacrylic acid) hydrogel

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