Preparation and characterization of nano and micro particles of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) via emulsification/solvent evaporation and nanoprecipitation techniques

Farrag, Yousof; Montero, Belén; Rico, Maite; Barral, L.; Bouza, Rebeca

doi:10.1007/s11051-018-4177-7

Cited by 19 publications

(14 citation statements)

References 54 publications

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“…25 Water is the most frequently used antisolvent, and saline solutions or buffers are often used as well. 15 For mixing, one way is to add a solvent solution containing hydrophobic components to an aqueous solution under mixing. Alternatively, the aqueous phase can be added to the organic phase.…”

Section: Nanoprecipitationmentioning

confidence: 99%

Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Liu

Yang

Zou

et al. 2019

Ind. Eng. Chem. Res.

130

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Significant efforts have been made to fabricate drug-loaded nanoparticles for drug delivery. Nanoprecipitation is a simple and versatile method for making various types of polymer nanoparticles with well-controlled particle size, size distribution, and surface properties. This review presents a critical overview of three different widely used nanoprecipitation techniques, namely, traditional nanoprecipitation in bulk solutions, flash nanoprecipitation, and microfluidic-based nanoprecipitation. The review starts with the comparison of these three different nanoprecipitation methods summarizing their key characteristics, advantages, and disadvantages. Then, different types of nanoparticles synthesized using nanoprecipitation are presented including di-block copolymer nanoparticles and natural polymer nanoparticles. A special focus is placed on comparing different drug-loaded polymer nanoparticles prepared using different nanoprecipitation approaches including their synthesis methods, drug loading, encapsulation efficiency, nanoparticle properties (e.g., size, PDI, etc.), and stability. Finally, the principle of forming nanoparticles with well-controlled properties is discussed to fundamentally understand the intricate interplay between mixing, supersaturation, nucleation, and particle growth, aiming to provide a general guideline for making drug-loaded nanoparticles based on nanoprecipitation.

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Section: Nanoprecipitationmentioning

confidence: 99%

Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Liu

Yang

Zou

et al. 2019

Ind. Eng. Chem. Res.

130

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“…e spherical porous micro-and nanoparticles produced by the emulsification/solvent evaporation were with a size of 300 to 20 μm. It has been found that the size, porosity, and the particle size distribution can be controlled by the choice of surfactant and polymer concentration during the emulsification process, while choosing the appropriate antisolvent and adjusting its polarity were crucial for obtaining spherical particles through nanoprecipitation [55].…”

Section: Microscopic Methods In Nanomaterials Characterisationmentioning

confidence: 99%

“…Micrographs of micro-and nanoparticles of PHBV prepared by nanoprecipitation method using 0.5% PHBV in dimethylformamide (DMF) as solvent and water as antisolvent (a) and 0.1% PHBV in DMF as solvent and 10% NaCl solution in water as antisolvent (b); microparticles of PHBV prepared by emulsification/solvent evaporation method using 1% PHBV in dichloromethane (DCM) and sodium dodecyl sulphate (SDS) as surfactant in a concentration of 1% (c) (adapted with permission from ref [55]…”

mentioning

confidence: 99%

Scanning Electron Microscopy and Atomic Force Microscopy: Topographic and Dynamical Surface Studies of Blends, Composites, and Hybrid Functional Materials for Sustainable Future

Rydz

Šišková

Eckstein

2019

Advances in Materials Science and Engineering

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Microscopic techniques are often used in material science, enabling the assessment of the morphology, composition, physical properties, and dynamic behaviour of materials. The review focuses on the topographic and dynamical surface studies of (bio)degradable polymers, in particular aliphatic polyesters, the most promising ones. The (bio)degradation process promotes physical and chemical changes in material properties that can be characterised by microscopic techniques. These changes occurring both under controlled conditions as well as in the processing stage or during use indicate morphological and structural transformations resulting from the deterioration of the material and have a significant impact on the characteristic of materials used in many applications, for example, for use as packaging.

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“…PHBV biopolymer with 12 wt.% hydroxyvalerate (HV) content and with 10 wt% of citric acid plasticized pellets was purchased from Goodfellow Cambridge, UK. Microparticles of PHBV between 2 and 4 μm were produced by the emulsification/solvent evaporation method in our laboratory with a PHBV concentration of 1% and a concentration of sodium dodecylsulphate (SDS) surfactant of 15% . SDS purchased from Scharlab, Spain.…”

Section: Methodsmentioning

confidence: 99%

Novel Self‐Reinforced Films Based on Poly (3‐Hydroxybutyrate‐Co‐3‐Hydroxyvalerate) (PHBV) and PHBV Microparticles

Malmir

Montero

Rico

et al. 2018

Polymer Engineering & Sci

Self Cite

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Biodegradable self‐reinforced films of poly (3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) and PHBV microparticles were prepared through the solvent casting method (srPHBV). Differential scanning calorimetry (DSC), wide angle X‐ray scattering (WAXS) and polarized optical microscopy results confirmed the nucleating effect of PHBV microparticles. WAXS proved that diffractograms of PHBV and srPHBV‐6 films at room temperature contain the main characteristic diffraction peaks of an orthorhombic α‐type crystalline structure. Small angle X‐ray scattering (SAXS) showed a similar decrement rate of long spacing in PHBV and srPHBV films. SAXS/WAXS data revealed that when the amount of filler was increased, lamellae thickness grew. Transmission electron microscopy images illustrated well filler dispersion in the srPHBV films. Scanning electron microscopy results exhibited a significant reduction in porosity for srPHBV films once the PHBV microparticles were added. Atomic force microscopy analysis showed higher surface roughness after filler incorporation. Samples of srPHBV films showed higher barrier properties against water vapor, oxygen, and carbon dioxide. Combined properties of srPHBV films revealed the possibility of being suitable candidates for food packaging applications. POLYM. ENG. SCI., 59:E120–E128, 2019. © 2018 Society of Plastics Engineers

show abstract

Preparation and characterization of nano and micro particles of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) via emulsification/solvent evaporation and nanoprecipitation techniques

Cited by 19 publications

References 54 publications

Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Scanning Electron Microscopy and Atomic Force Microscopy: Topographic and Dynamical Surface Studies of Blends, Composites, and Hybrid Functional Materials for Sustainable Future

Novel Self‐Reinforced Films Based on Poly (3‐Hydroxybutyrate‐Co‐3‐Hydroxyvalerate) (PHBV) and PHBV Microparticles

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