Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture

Calcium orthophosphate-based biocomposites and hybrid biomaterials

“…They were implanted in the radius of rabbits and showed a high biocompatibility and partial resorption after 12 weeks. Nano-HA/chitosan biocomposites with improved mechanical stability were prepared from HA/chitosan nanorods [577]. Nano-HA/PLLA biocomposites of high porosity (*90%) were prepared using thermally induced phase separation [578].…”

Chitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo tests

“…Composites comprising calcium phosphates and natural biopolymers are widely used as biomaterials for bone tissue repair and engineering [1][2][3][4][5]. Hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2 , has been used as a principal inorganic component of synthetic materials for orthopaedy and stomatology for a long time.…”

“…This mineral can be regarded, with some limitations, as a crystallochemical analogue of the main mineral constituent of human and animal skeletal tissues [6]. A wide range of biomaterials for different clinical applications can be created on the basis of two components: nanocrystalline apatite and chitosan [3][4][5][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Chitin is the second (after cellulose) most abundant natural polysaccharide.…”

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

“…It is highly biocompatible, biodegradable, porous structure, suitable for cell ingrowth, osteoconduction and intrinsic antibacterial nature, chitosan has been developed considerably in biomedical applications [34]. Its application includes cartilage tissue engineering [35], wound healing and orthopedic applications [36]. Degradable polymeric implants eliminate the need for a second surgical operation [37].…”