Preparation and characterization of alginate-PVA-based semi-IPN: controlled release pH-responsive composites

Khalid, Ikrima; Ahmad, Mahmood; Minhas, Muhammad Usman; Barkat, Kashif

doi:10.1007/s00289-017-2079-y

Cited by 66 publications

(25 citation statements)

References 49 publications

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“…In the case of neat SA/PVA, the peak located at 2θ = 11.9° was due to the amorphous diffraction peak of SA. The peaks located at 2θ = 32°, 34°, and 45° were due to the presence of excrescent calcium ions in SA [26]. The sharp peak presented at 2θ = 20.2° was ascribed to the diffraction peak of PVA [18].…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide Reinforced Alginate/PVA Double Network Hydrogels for Efficient Dye Removal

Liu

Xiong

et al. 2018

Polymers

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Dually crosslinked graphene oxide reinforced alginate/polyvinyl alcohol (PVA) double network (DN) hydrogels were prepared via a facile freeze/thaw method followed by soaking in a Ca2+ solution. The morphology and structure of the hydrogels were systematically examined by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The effects of pH, dosage of hydrogel, adsorption time, and temperature on the adsorptive property of DN hydrogels towards methylene blue (MB) were also studied. Results indicated that the hydrogels exhibited typical 3D porous structures and had an efficient adsorption effect towards MB due to strong interactions between DN hydrogels and MB molecules. The adsorption isotherm was found to coincide with the Langmuir model with a monolayer adsorption. The highest adsorption capacity of DN hydrogels for MB was examined as 480.76 mg·g−1.

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Section: Resultsmentioning

confidence: 99%

Graphene Oxide Reinforced Alginate/PVA Double Network Hydrogels for Efficient Dye Removal

Liu

Xiong

et al. 2018

Polymers

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“…Analysis of FTIR was done for drug, SA, AMPS, unloaded SA-co-poly(AMPS) hydrogels and drug loaded SA-co-poly(AMPS) hydrogels. Pestle and mortar were used to crush all samples to desired particle size carefully and then NICOLET 380 FTIR (Thermo Fisher Scientific, Ishioka, Japan) was used for analysis in range of 4000–500 cm −1 [ 57 ].…”

Section: Methodsmentioning

confidence: 99%

Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier

Suhail

Khan

Rosenholm

et al. 2021

Gels

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The aim of the current study was to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time. In this research work, sodium alginate-co-poly(2-acrylamido-2-methyl propane sulphonic acid) (SA-co-poly(AMPS)) hydrogels were prepared by the free radical polymerization technique, where sodium alginate (SA) and 2-acrylamido-2-methyl propane sulphonic acid (AMPS) were used as the polymer and monomer while ammonium peroxodisulfate (APS) and N,N′-Methylene bisacrylamide (MBA) were used as the initiator and cross-linker, respectively. A swelling study was performed to determine the swelling index of developed hydrogels in both acidic (pH 1.2) and basic (pH 7.4) media and pH-independent swelling was observed due to the presence of AMPS. An in vitro release study was conducted to evaluate the percentage of drug released, and a high release of the drug was found at the higher pH of 7.4. Sol–gel analysis was performed to analyze the crosslinked and uncrosslinked part of the hydrogels, and results showed a rise in gel fraction as the composition of SA, AMPS and MBA increased while the sol fraction decreased and vice versa. This work demonstrated a potential for sustained delivery of diclofenac sodium by employing various concentration of SA, AMPS and MBA.

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“…FTIR analysis was performed for the model drug, carbopol, acrylic acid, unloaded Carb934-g-poly (acrylic acid) hydrogels and drug-loaded Car934-g-poly (acrylic acid) hydrogels. All the excipients used in the preparation of hydrogels were crushed in a mortar and pestle to the desired size thoroughly and then analyzed by Nicolet 380 FTIR (Thermo Fisher Scientific, MA, USA) in the range of 4000–500 cm −1 [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…Acrylic acid is a soluble polymer that has attracted attention because of its widespread biomedical and pharmaceutical applications [ 19 , 20 ]. Acrylic acid is a pH-sensitive polymer used in stimuli-sensitive polymeric carrier systems, especially in pH-sensitive hydrogels like carbopol, and has maximum swelling at alkaline pH and, hence, releases the drug in a high concentration at alkaline pH [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Using Carbomer-Based Hydrogels for Control the Release Rate of Diclofenac Sodium: Preparation and In Vitro Evaluation

Suhail

Minhas

2020

Pharmaceuticals

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The aim of the current research work was to prepare Car934-g-poly(acrylic acid) hydrogels by the free-radical polymerization technique. Various concentrations of carbopol, acrylic acid and ethylene glycol dimethacrylate were employed for the fabrication of Car934-g-poly(acrylic acid) hydrogels. Fourier-transform infrared spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Scanning electron microscope (SEM) and Powder X-ray diffractometry (PXRD) studies were performed to know the structural arrangement, thermal stability, physical appearance and amorphous network of developed hydrogels. FTIR analysis revealed that carbopol reacted with acrylic acid during the process of polymerization and confirmed the grafting of acrylic acid over the backbone of carbopol. TGA and DSC studies showed that developed hydrogels were thermally stable. Surface morphology was analyzed by SEM, which confirmed a porous network of hydrogels. PXRD analysis indicated that crystallinity of the drug was reduced by the amorphous network of hydrogels. Furthermore, swelling studies for all developed hydrogels were performed at both media, i.e., pH 1.2 and 7.4, and higher swelling was exhibited at pH 7.4. Sol–gel analysis was performed to evaluate the soluble unreacted part of the fabricated hydrogels. Similarly, an in-vitro study was conducted for all hydrogel formulations at both acidic (pH 1.2) and basic (pH 7.4) mediums, and a greater drug release was observed at pH 7.4. Different kinetics such as zero-order, first-order, the Higuchi model and the Korsmeyer–Peppas model were applied to know the mechanism of release order of drugs from the hydrogels.

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Preparation and characterization of alginate-PVA-based semi-IPN: controlled release pH-responsive composites

Cited by 66 publications

References 49 publications

Graphene Oxide Reinforced Alginate/PVA Double Network Hydrogels for Efficient Dye Removal

Graphene Oxide Reinforced Alginate/PVA Double Network Hydrogels for Efficient Dye Removal

Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier

Using Carbomer-Based Hydrogels for Control the Release Rate of Diclofenac Sodium: Preparation and In Vitro Evaluation

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