Preparation and antioxidant activities of polysaccharides obtained from abalone viscera by combination of enzymolysis and multiple separation methods

Guo, Shu; Wang, Jiao; He, Chuanbo; Wei, Haocheng; Ma, Ying; Xiong, Hua

doi:10.1111/1750-3841.15520

Cited by 19 publications

(11 citation statements)

References 52 publications

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“…The content of sulfate group is significantly different with different extraction methods and sources, which leads to significant differences in the activity of MSPs from different sources or even the same source. MSPs from abalone have a variety of fragments, and their activity is related to molecular weight and sulfate content [92,93]. A fraction named AGP33 with sulfates occur at 3-O-and 4-O-positions showed a better anticoagulant activity than its desulfated product [93].…”

Section: Role Of Sulfate Group and Sulphation Patternmentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.

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Section: Role Of Sulfate Group and Sulphation Patternmentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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“…Along with the high consumption rate of abalone meat. the abandonment of processing waste is more than 27,000 tons (based on 15% of discard rate) of viscera and gonad tissue every year [ 28 ]. Therefore, abalone protein and peptide are becoming a very promising candidate for dietary nutrients and skin care products [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Computer-Aided Virtual Screening and In Vitro Validation of Biomimetic Tyrosinase Inhibitory Peptides from Abalone Peptidome

Kongsompong

E-kobon

Taengphan

et al. 2023

IJMS

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Hyperpigmentation is a medical and cosmetic problem caused by an excess accumulation of melanin or the overexpression of the enzyme tyrosinase, leading to several skin disorders, i.e., freckles, melasma, and skin cancer. Tyrosinase is a key enzyme in melanogenesis and thus a target for reducing melanin production. Although abalone is a good source of bioactive peptides that have been used for several properties including depigmentation, the available information on the anti-tyrosinase property of abalone peptides remains insufficient. This study investigated the anti-tyrosinase properties of Haliotis diversicolor tyrosinase inhibitory peptides (hdTIPs) based on mushroom tyrosinase, cellular tyrosinase, and melanin content assays. The binding conformation between peptides and tyrosinase was also examined by molecular docking and dynamics study. KNN1 showed a high potent inhibitory effect on mushroom tyrosinase with an IC50 of 70.83 μM. Moreover, our selected hdTIPs could inhibit melanin production through the reductions in tyrosinase activity and reactive oxygen species (ROS) levels by enhancing the antioxidative enzymes. RF1 showed the highest activity on both cellular tyrosinase inhibition and ROS reduction. leading to the lower melanin content in B16F10 murine melanoma cells. Accordingly, it can be assumed that our selected peptides exhibited high potential in medical cosmetology applications.

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“…The molecular weights of the PEP-1 and PEP-2 were determined using high-performance gel permeation chromatography (HPGPC, 1260 Infinity MDS, Agilent, USA) with a deferential refraction detector and a multi-angle laser light scatterer (Guo et al, 2020). The content of monosaccharide was analyzed by high-performance liquid chromatography (1200, Agilent, USA) as reported by Liu et al (2020).…”

Section: Molecular Weight and Monosaccharide Composition Analysismentioning

confidence: 99%

Purification, characterization, and antioxidant ability of polysaccharides from Phascolosoma esculentas

Zhou,

Cai,

Ruan

et al. 2024

Food Science & Nutrition

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The polysaccharide was extracted from Phascolosoma esculenta (PEP). Two purified polysaccharides (PEP‐1 and PEP‐2) were obtained by the column chromatography separation method. The molecular weights of PEP‐1 and PEP‐2 were 33.6 and 5.7 × 103 kDa, respectively. PEP‐1 and PEP‐2 had the same monosaccharides composition, but their molar ratios varied. The in vitro antioxidant activity of the PEP, PEP‐1, and PEP‐2 were investigated by scavenging free radicals like 3‐ethylbenzoth‐iazoline‐6‐sulfonic acid (ABTS), •OH, and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH). Additionally, the in vivo antioxidant activity of PEP‐1 was examined using the Caenorhabditis elegans (C. elegans) organism. Results showed that PEP‐1 was much more effective than PEP and PEP‐2 at scavenging DPPH, •OH, and ABTS radicals. Additionally, PEP‐1 strengthened C. elegans' ability to endure oxidative stress. PEP‐1 possessed the in vivo antioxidant capacity, including the reactive oxygen species (ROS) content reducing, and protective effect on antioxidant enzyme activities in C. elegans. In summary, PEP, PEP‐1, and PEP‐2 might have the potential to develop as functional foods and clinical medications.

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Preparation and antioxidant activities of polysaccharides obtained from abalone viscera by combination of enzymolysis and multiple separation methods

Cited by 19 publications

References 52 publications

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Computer-Aided Virtual Screening and In Vitro Validation of Biomimetic Tyrosinase Inhibitory Peptides from Abalone Peptidome

Purification, characterization, and antioxidant ability of polysaccharides from Phascolosoma esculentas

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