Preparation and anticoagulant activity of a low-molecular-weight sulfated chitosan

Вихорева, Г. А.; Bannikova, G. E.; Stolbushkina, P. P.; Панов, Алексей Валерьевич; Дрозд, Н. Н.; Makarov, V. A.; Варламов, В. П.; Гальбрайх, Л. С.

doi:10.1016/j.carbpol.2005.05.022

Cited by 141 publications

(104 citation statements)

References 18 publications

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“…9 Dentre os polissacarídeos quimicamente sulfatados que podem atuar como anticoagulantes pode-se citar a quitina e quitosana, glucanas, galactomananas, galactanas, que podem ser obtidos de diversas fontes, como por exemplo, de liquens, fungos e plantas. 10 Além das atividades anticoagulantes, polissacarídeos sulfatados também podem apresentar atividades antiarterioescleróticas, antiproliferativas, antiangiogênicas, antivirais, anti-inflamatórias e anti-metastáticas.…”

Section: Introductionunclassified

Modificação química da pectina do melão caipira (Cucumis melo var. Acidulus)

Sousa¹,

Ribeiro²,

Santos³

et al. 2017

Quim. Nova

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Section: Introductionunclassified

Modificação química da pectina do melão caipira (Cucumis melo var. Acidulus)

Sousa¹,

Ribeiro²,

Santos³

et al. 2017

Quim. Nova

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“…Chitosan has attracted much attention as a biomedical material, as it exhibits a wide variety of biological activities, such as antitumor activities [7]- [9], immunostimulating effects [10], antiallergic effects [11], hemostatic agent [12], anticoagulant effects [13] [14] hypocholesterolemic effects [15], antiinflammatorty activities [16], free radical scavenging activities [17], antimicrobial effects [18], antibacterial effects [19] [20] wound-healing effects [21] [22], antifungal activities [23] [24] and antiviral activity [25]. However, because of its high molecular weight and water-insolubility, the applications of chitosan are severely limited.…”

Section: Introductionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

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“…Anticoagulant effect of chitosan arises from especially its inhibition of IIa and Xa factors. It is an important component of prothrombinase complex [25,27].…”

Section: Its Anti -Coagulant Effectmentioning

confidence: 99%

A Renewable Natural Bioactive Polysaccharide: An Overview to Chitosan

Ayhan¹,

Şanlıer²

2015

IJNFS

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Chitin is a polysaccharide, which can be found in the structures of some insects, yeasts and fungi in nature.Chitosan is a compound, which is obtained by de -acetylation of chitin. Apart from that, there is chitosan naturally on the cell walls of some fungi, in yeasts and protozoa and in the outer shells of crustaceans. Chitosan is a molecule, which is frequently used in health field and food industry. It is frequently used in bioactive packing especially for its antibacterial effect. In addition, it is used in many areas such as waste treatment for its antioxidant feature. Areas of use of chitosan are expanding because it is an edible agent and because of its low level of toxic activity, and new areas of use are discovered everyday in good and health sectors.

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Preparation and anticoagulant activity of a low-molecular-weight sulfated chitosan

Cited by 141 publications

References 18 publications

Modificação química da pectina do melão caipira (Cucumis melo var. Acidulus)

Modificação química da pectina do melão caipira (Cucumis melo var. Acidulus)

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

A Renewable Natural Bioactive Polysaccharide: An Overview to Chitosan

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