Preparation and anti-cancer activity of polymer-encapsulated curcumin nanoparticles

Ha, Phuong Thu; Le, Mai Huong; Hoang, Thi My Nhung; Le, Thi Thu Huong; Quang, Duong Tuan; Tran, Thi Hong Ha; Tran, Dai Lam; Nguyen, Xuan Phuc

doi:10.1088/2043-6262/3/3/035002

Cited by 25 publications

(17 citation statements)

References 30 publications

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“…Antitumor Activity Ha et al [82] developed water soluble copolymer Cur-PLA-TPGS-, Cur-Gl-, Cur-OCMCS-, and Cur-OCMCS-Fol-encapsulated curcumin nanoparticles and found that these nanoparticles could be used in cancer therapy. Pan et al [83] evaluated the antitumor effects of the curcumin analogue GL63 on radioresistant nasopharyngeal carcinoma (NPC) CNE2R cells and parental CNE2 cells.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Curcumin and its protective and therapeutic uses

Agrawal¹,

Goel²

2016

Natl J Physiol Pharm Pharmacol

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Curcumin is a yellow orange powder, which is extracted from the turmeric plant (Curcuma longa). Curcumin is the principal curcuminoid of the turmeric (C. longa). Curcumin was first isolated in 1815 and its chemical structure was determined by Roughley and Whiting in 1973. It has been identified as 1,6-heptadiene-3,5-dione-1,7-bis (4-hydroxy-3-methoxyphenyl)-(1e,6e) or diferuloylmethane. Turmeric has been listed as ''generally recognized as safe'' (GRAS) as a coloring and flavoring agent in food by the US Food and Drug Administration (FDA). As per WHO, as an additive the daily acceptable dose of curcumin for humans has been defined as 0-3 mg/kg body weight. Curcumin can be administered by different routes as topical, oral, and inhalational. Curcumin inserts deep into the cell membrane in a manner similar to cholesterol. Curcumin has a high lipophilic character, and body fat has a high percentage of bound curcumin. The systemic bioavailability of orally administered curcumin is low in humans and only traces of it have been found in the liver and portal circulation. Piperine has been reported to increase the bioavailability of curcumin. Recently, it has been reported that newly developed nanoparticulate curcumin has better bioavailability. There is a growing list of disease conditions that can be treated by curcumin. Curcumin has been found to have therapeutic effects in wound healing and in various types of arthritis, cardiovascular diseases, diabetes, pulmonary diseases, Parkinson's disease, and in Alzheimer's disease. Curcumin has been reported to have potential role in the treatment of atherosclerosis, arthritis, chronic anterior uveitis, colon cancer, familial adenomatous polyposis, hypercholesteremia, inflammatory bowel disease, pancreatic cancer, pancreatitis, psoriasis, ulcerative colitis, and even HIV.

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Section: Antibacterial Activitymentioning

confidence: 99%

Curcumin and its protective and therapeutic uses

Agrawal¹,

Goel²

2016

Natl J Physiol Pharm Pharmacol

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“…Among the various transition metal oxides, MnO 2 is one of the most studied active materials for pseudo-capacitors because of its low cost, high positive electrode potential and relatively low molecular weight. 33,34 However, the poor stability presented after just a few charge-discharge cycles is a crucial limitation for practical application of MnO 2 . Moreover, the electrochemical and catalysis properties of MnO 2 are strongly dependent on its dimensions, morphology and crystalline structure.…”

Section: Introductionmentioning

confidence: 99%

Enhanced catalytic and supercapacitor activities of DNA encapsulated β-MnO₂nanomaterials

Ede

Ramadoss

Anantharaj

et al. 2014

Phys. Chem. Chem. Phys.

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À1 at 5 mV s À1 was observed for the flake-like structure, which is higher compared to that of the wire-like structure. The flake-like MnO 2 nanostructure exhibited an excellent long-term stability, retaining 81% of initial capacitance even after 4000 cycles, whereas for the wire-like MnO 2 nanostructure, capacitance decreased and the retention value was only 70% over 4000 cycles. In the future, the present approach can be extended for the formation of other oxide-based materials using DNA as a promising scaffold for different applications such as homogeneous and heterogeneous organic catalysis reactions, Li-ion battery materials or for the fabrication of other high performance energy storage devices.

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“…Due to their small size and mobility, nanoparticles have higher cell uptake when compared to microparticles and are available to a wider range of cellular and intracellular targets. Ha et al reported the use of fluorescence images to study the cellular uptake of a polymer encapsulated curcumin nanoparticles and suggested that the absorption of curcumin takes place into the cells instead of adhesion to the surface as indicated by their distribution in the nuclear zone. In a study by Yuan and Zheng the fluorescence intensity was more in HepG2 cells treated with curcumin incorporated glycyrrhetic acid modified pullulan nanoparticles compared to those treated with native curcumin.…”

Section: Resultsmentioning

confidence: 99%

Water Soluble Octenyl Succinylated Cassava Starch‐Curcumin Nanoformulation With Enhanced Bioavailability and Anticancer Potential

2018

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The present study reports the preparation and evaluation of a water soluble octenyl succinylated cassava starch‐curcumin nanoformulation with enhanced bioavailability and anticancer potential. The major drawback of curcumin as a bioactive compound is its poor aqueous solubility and the resultant low bioavailability. In this study, curcumin has been incorporated in octenyl succinate cassava starch by a wet grinding method and the product is characterized by Fourier transform infra red spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), atomic force microscopy (AFM), and X‐ray diffraction (XRD) analyses. The OSA starch loaded nanocurcumin is found to be non‐toxic to L929 cells, but shows anti‐cancer potential to HeLa cells. A significant enhancement in cellular uptake also can be achieved for the OSA starch loaded nanocurcumin as revealed by fluorescence microscopy. The in vitro release of curcumin from the nanostarch matrix is more controlled at simulated intestinal pH than that at gastric pH. Pharmacokinetic study shows that bioavailability of nanocurcumin is increased by about 71.27%.

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Preparation and anti-cancer activity of polymer-encapsulated curcumin nanoparticles

Cited by 25 publications

References 30 publications

Curcumin and its protective and therapeutic uses

Curcumin and its protective and therapeutic uses

Enhanced catalytic and supercapacitor activities of DNA encapsulated β-MnO₂nanomaterials

Water Soluble Octenyl Succinylated Cassava Starch‐Curcumin Nanoformulation With Enhanced Bioavailability and Anticancer Potential

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Preparation and anti-cancer activity of polymer-encapsulated curcumin nanoparticles

Cited by 25 publications

References 30 publications

Curcumin and its protective and therapeutic uses

Curcumin and its protective and therapeutic uses

Enhanced catalytic and supercapacitor activities of DNA encapsulated β-MnO2nanomaterials

Water Soluble Octenyl Succinylated Cassava Starch‐Curcumin Nanoformulation With Enhanced Bioavailability and Anticancer Potential

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Product

Resources

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Enhanced catalytic and supercapacitor activities of DNA encapsulated β-MnO₂nanomaterials