“…Common reasons for the failure to achieve an FIO 2 close to 1.0 include inadequate time for preoxygenation, 10,12 a leak under the face mask, 2,5,10,17 use of systems incapable of delivering high oxygen concentrations, 18 and rebreathing of exhaled gases, such as when low FGF is used in a semiclosed circle absorber system. 7,8 In the current study, the subjects were non-bearded and were familiar with the use of tight-fitting masks so as to avoid leaks between the mask and the face. In addition, the clinical endpoints indicative of a sealed system (expansion and contraction of the reservoir bag corresponding with the respiratory cycle, measurement of breath-by-breath respiratory gases, and the presence of a normal capnogram) were confirmed in all subjects.…”