Preoperative radiotherapy in esophageal carcinoma: a meta-analysis using individual patient data (oesophageal cancer collaborative group)

Arnott, S.J.; Duncan, W.; Gignoux, M; Girling, D J; Hansen, Hanne Sand; Launois, B; Nygaard, K; Parmar, Mahesh; Roussel, A; Spiliopoulos, G; Stewart, Lesley; Tierney, Jayne; Wang, Mei; Zhang, Rugang

doi:10.1016/s0360-3016(97)00569-5

Cited by 147 publications

(64 citation statements)

References 12 publications

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“…The treatment dilemma is confounded by data that are not clear on the overall benefi t of multimodality therapy. Several meta-analyses have suggested a benefi t from multimodality therapy, 12,[22][23][24][25] but the data do not reach statistical signifi cance in some of these studies. [22][23][24] However, many of these data demonstrate heterogeneic patient populations without considering tumor biology or pathological response.…”

Section: Introductionmentioning

confidence: 95%

The Impact of Age on Morbidity and Mortality following Esophagectomy for Esophageal Cancer

2013

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Section: Introductionmentioning

confidence: 95%

The Impact of Age on Morbidity and Mortality following Esophagectomy for Esophageal Cancer

2013

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“…To further investigate the value of the trimodal approach vs surgery alone, several meta-analyses were performed. With differences in the endpoint analyzed and background of the evaluated studies, few of them revealed only a nonsignificant trend in favor of RT-CT, while most of them showed a significant benefit (70)(71)(72)(73)(74)(75)(76)(77). If the role of preoperative RT-CT over surgery alone seems well-established, its benefit over preoperative CT alone seems more controversial.…”

Section: Trimodal Approachmentioning

confidence: 99%

Combined Modality Therapy for Thoracic and head and Neck Cancers: A Review of Updated Literature Based on a Consensus Meeting

Franco

Fiorentino

Dionisi³

et al. 2016

Tumori

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Purpose: Combined modality therapy is a mainstay option for thoracic malignancies and head and neck cancers. The integration of different strategies is based on the multidisciplinary approach of modern clinical oncology. Radiation oncologists have to be educated, trained, and updated to provide state-of-the-art care to cancer patients and thus educational meetings are crucial. Methods: The Italian Association of Radiation Oncology Young Members Working Group (AIRO Giovani) organized its 8 th national meeting, focused on combination therapy in lung, esophageal, and head and neck cancer (with a specific focus on larynx-preservation strategies for larynx/hypopharynx tumors), involving young professionals working in Italy. The meeting was addressed to young radiation oncologists, presenting state-of-the-art knowledge, based on the latest evidence in this field. We performed a review of the current literature based on the highlights of the Congress. Results: The multimodality approach of head and neck and thoracic malignancies includes surgery, chemotherapy, and radiotherapy, but also has to take into account new information and data coming from basic and translational research and including molecular biology, genetics, and immunology. All these aspects are crucial for the treatment of non-small-cell lung cancer and esophageal, esophagogastric junction, and larynx/hypopharynx malignancies. The integration of different treatments in the clinical decision-making process to combine therapies is crucial. Conclusions: Combination therapy has proved to be a consolidated approach in these specific oncologic settings, highlighting the importance of multimodality management in modern clinical oncology. Dedicated meetings on specific topics are helpful to improve knowledge and skills of young professionals in radiation oncology.

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“…Doses varied from 20 Gy to 40 Gy, but even in the trial with the higher doses, the fractionation was far from optimal (40 Gy in eight fractions). A meta-analysis on 1,147 patients was performed and has shown a 11% reduction in mortality (confidence interval 95%: 0.78-1.01), p = 0.062 (12). The benefit is limited to 3% increase in survival at 5 years.…”

Section: Preoperative Radiotherapymentioning

confidence: 99%

Preoperative Chemoradiotherapy for Esophageal Cancer

2012

N Engl J Med

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Preoperative radiotherapy in esophageal carcinoma: a meta-analysis using individual patient data (oesophageal cancer collaborative group)

Cited by 147 publications

References 12 publications

The Impact of Age on Morbidity and Mortality following Esophagectomy for Esophageal Cancer

The Impact of Age on Morbidity and Mortality following Esophagectomy for Esophageal Cancer

Combined Modality Therapy for Thoracic and head and Neck Cancers: A Review of Updated Literature Based on a Consensus Meeting

Preoperative Chemoradiotherapy for Esophageal Cancer

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