2018
DOI: 10.1002/14651858.cd002102.pub3
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Abstract: Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma (Review)

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Cited by 45 publications
(33 citation statements)
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References 174 publications
(8 reference statements)
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“…reported a high 5–year LR rate of 14% and poor 5-year overall survival (OS) of 64% among patients with locally advanced rectal cancer (LARC) undergoing curative surgery and postoperative concurrent chemoradiotherapy (CCRT) [ 3 ]. A German study reported a marked reduction in LR among patients receiving preoperative CCRT [ 4 , 5 ], and similar results have been previously reported [ 6 8 ]. Therefore, preoperative CCRT has since been the recommended as a standard treatment for patients with LARC.…”
Section: Introductionsupporting
confidence: 80%
See 1 more Smart Citation
“…reported a high 5–year LR rate of 14% and poor 5-year overall survival (OS) of 64% among patients with locally advanced rectal cancer (LARC) undergoing curative surgery and postoperative concurrent chemoradiotherapy (CCRT) [ 3 ]. A German study reported a marked reduction in LR among patients receiving preoperative CCRT [ 4 , 5 ], and similar results have been previously reported [ 6 8 ]. Therefore, preoperative CCRT has since been the recommended as a standard treatment for patients with LARC.…”
Section: Introductionsupporting
confidence: 80%
“…Preoperative rather than postoperative radiotherapy has been reported to reduce the LR rate and complication rate [4][5][6][7][8]. Preoperative radiotherapy may induce tissue swelling and local inflammation, which requires time to subside.…”
Section: Plos Onementioning
confidence: 99%
“…[7][8][9][10][11] These results were confirmed by several meta-analyses, which consistently found that the hazard ratio for local recurrence with RT was approximately 0.5 compared with surgery alone. [12][13][14] Despite the strong evidence supporting the use of neoadjuvant RT for patients with stage II-III rectal cancer, a subset of patients may be at low risk for locoregional recurrence based on proximal tumor location and MRI-determined "safe" circumferential resection margin. 5,6,11,15 Based on this moderate evidence, a conditional recommendation may be made to omit neoadjuvant RT in favor of upfront surgery for patients in clinical stage IIA (cT3a/b N0) when the cancer is located >10 cm from the anal verge and there is a predicted circumferential resection margin 2 mm and the absence of extramural vascular invasion as determined by MRI with rectal cancer protocol.…”
Section: What Are the Indications For Neoadjuvant Rt For Operable Recmentioning
confidence: 99%
“…The National Institute of Clinical Excellence (NICE) 2020 guideline update recommends pre-operative chemo-radiotherapy (CRT) for T3/T4 or any N, M0 RC's [11]. Neo-adjuvant treatment in RC, down-stages the disease, and reduces overall mortality and disease recurrence [12]. At the National Hospital of Sri Lanka, RC patients with CT stage T3 and T4 receive neo-adjuvant CRT.…”
Section: Introductionmentioning
confidence: 99%