Preoperative plus postoperative neutrophil‑lymphocyte ratio for predicting overall survival following partial hepatectomy for hepatocellular carcinoma

Wu, Mingmin; Yang, Shaoxing; Feng, Xueping; Yu, Fei; Liu, Xiangchen; Dong, Jiahong

doi:10.3892/ol.2020.12238

Cited by 13 publications

(12 citation statements)

References 41 publications

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“…Further analysis found that there was no correlation between clinicopathological indicators including tumor stage and postNLR. Our previous study found that the preoperative inflammatory indicators were related to tumor burden such as tumor size, while the preoperative tumor burden was not correlated with postoperative inflammatory indicators [38]. The possible reason was that after the primary tumor burden was removed, the host's immune response has changed [39].…”

Section: Discussionmentioning

confidence: 97%

Prognostic value of the postoperative neutrophil-lymphocyte ratio in solid tumors: A meta-analysis

Yang

Feng

et al. 2021

PLoS ONE

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Purpose Numerous studies have demonstrated that a variety of systemic inflammatory markers were associated with the survival of different tumors. However, the association between elevated postoperative neutrophil-lymphocyte ratio (postNLR) and long-term outcomes, including overall survival (OS), disease-free survival (DFS), in patients with solid tumors remains controversial. A systematic review was conducted to explore the association between the postNLR and long-term outcomes in solid tumors. Materials and methods Relevant literature was identified using PubMed, Embase, Web of Science, and the Cochrane Library from the initiation of the databases to October 2020. Data were extracted from included studies reporting hazard ratio (HR) and 95% confidence intervals (CI), and were pooled using generic inverse-variance and random-effects modeling. 25 studies reporting on7539 patients were included in the analysis. Results Elevated postNLR was associated with poor OS (HR 1.87, 95% CI = 1.53–2.28; P < 0.00001), and worse DFS (HR 1.69, 95% CI = 1.28–2.22; P = 0.0002). Subgroup analyses showed that the trend of the pooled HR for most of the subgroups was not changed, and the heterogeneity of the same tumor type was not obvious. However, there was no correlation between high postNLR obtained within 7days and poor DFS (n = 3, HR 1.25, 95CI% = 0.54–2.88; P = 0.60). Conclusions Elevated postNLR might be a readily available and inexpensive biomarker for long-term outcomes in solid tumors. Multicenter and prospective studies are needed to explore the impact of the postNLR on the prognosis of solid tumors.

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Section: Discussionmentioning

confidence: 97%

Prognostic value of the postoperative neutrophil-lymphocyte ratio in solid tumors: A meta-analysis

Yang

Feng

et al. 2021

PLoS ONE

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“… 14 Our previous study confirmed this finding and revealed that a high preNLR was associated with a greater tumor burden, but there was no significant correlation between the postNLR and tumor burden. 15 Tumor recurrence is affected by many factors. Even after the HCC tumor is completely removed or ablated, the microenvironment of the remaining carcinogenic tissue in the liver can also cause recurrence of de novo HCC tumors.…”

Section: Discussionmentioning

confidence: 99%

“… 8–13 However, the treatment process for tumors is complicated and long, and we should not only pay attention to the influence of preoperative indicators on the prognosis of HCC but also to postoperative indicators. Previous studies showed that the immune status of HCC patients changed after the primary tumor burden was reduced, 14 , 15 and a high postNLR was associated with poor long-term prognosis. 16 , 17 However, the value of many postoperative inflammatory indicators was not clarified.…”

Section: Introductionmentioning

confidence: 99%

Combining Preoperative and Postoperative Inflammatory Indicators Can Better Predict the Recurrence of Hepatocellular Carcinoma After Partial Hepatectomy

Wu¹,

Yang²,

Feng³

et al. 2021

JIR

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Previous studies have shown that various preoperative inflammatory indicators can predict the prognosis of hepatocellular carcinoma (HCC), but the role of postoperative inflammatory indicators remains unclear. This study aimed to explore the prognostic value of postoperative inflammatory indicators and whether combining preoperative and postoperative inflammatory indicators can improve the predictive performance of the prognostic model. Patients and Methods: Eighty-eight patients with primary HCC were included in this study. A preoperative model, postoperative model, and combined model that integrated preoperative and postoperative inflammatory indicators were established. The prognostic value of the models was evaluated by the area under the curve of time-dependent receiver operating characteristic curves (td-AUC). Results: Multivariate analysis of preoperative and postoperative inflammatory indicators and clinicopathological indicators found that tumor number, alpha-fetoprotein (AFP) level, and the preoperative platelet-lymphocyte ratio (prePLR), preoperative prognostic nutritional index (prePNI), and postoperative neutrophil-lymphocyte ratio (postNLR) were independent prognostic factors for the disease-free survival. The prognostic efficacy of the postNLR at 2 years and 3 years was better than that of tumor number, AFP level, and the prePLR, and prePNI. The combined model had higher td-AUC values than the preoperative model, postoperative model, American Joint Committee on Cancer 8th edition stage, and Barcelona Clinic Liver Cancer stage at 2 years (0.814 vs 0.754, 0.765, 0.513 and 0.527, respectively), and 3 years (0.786 vs 0.749, 0.753, 0.509 and 0.529, respectively). The predictive performance of the combined model was better than that of the preoperative model, postoperative model, and traditional clinical stage. Conclusion: Postoperative inflammatory indicators were valuable prognostic indicators. The combination of preoperative and postoperative inflammatory indicators improved the predictive performance of the prognostic model. We should pay more attention to postoperative inflammatory indicators.

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“… 32 Furthermore, both pre- and postoperative NLR can predict the rate of all-cause mortality in patients with hepatocellular carcinoma after partial hepatectomy. 33 On the other hand, they may be also applied for estimating the current activity and predicting the prognosis of chronic inflammatory diseases. NLR above the optimal cut-off value was proposed as a determining factor for the current active systemic lupus erythematosus.…”

Section: Applying Serologic Indices To Clinical Use In Rheumatic Disementioning

confidence: 99%

Serological Biomarkers and Indices for the Current Activity and Prognosis of ANCA-Associated Vasculitis: Experience in a Single Centre in Korea

2021

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Small vessel vasculitis is composed of two types of vasculitis based on immune-complex deposits, immune-complex vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) according to the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis. In general, the current disease-states are assessed in three ways in real clinical practice such as activity, damage and functional status. Birmingham vasculitis activity score (BVAS, version 3) and five-factor score were calculated for assessing the cross-sectional activity and for predicting the prognosis of AAV, respectively. Since BVAS includes a wide spectrum of nine systemic items with differently weighted scores based on new-onset/worsening or persistent each symptom, it has been considered as the most reliable tool to assess AAV activity to date. However, since BVAS represents both cross-sectional and chronic clinical features, it has a limitation in flexibly reflecting the cross-sectional activity or severity of AAV. In addition, the heterogeneous items of BVAS are difficult to reflect the close correlation between BVAS and AAV pathogenesis. It is practically difficult to discover new biomarkers or indices that exceed the reliability of AAV-specific indices or acute-phase reactants established by long clinical experience. However, efforts to discover and develop new biomarkers or indices are expected to complement the clinical unmet need of existing AAV-specific indices and acute-phase reactants. In this review, we reviewed the serological biomarkers and indices that have been reported to date and introduced studies that investigated serological biomarkers and indices in Korean patients with AAV.

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Preoperative plus postoperative neutrophil‑lymphocyte ratio for predicting overall survival following partial hepatectomy for hepatocellular carcinoma

Cited by 13 publications

References 41 publications

Prognostic value of the postoperative neutrophil-lymphocyte ratio in solid tumors: A meta-analysis

Prognostic value of the postoperative neutrophil-lymphocyte ratio in solid tumors: A meta-analysis

Combining Preoperative and Postoperative Inflammatory Indicators Can Better Predict the Recurrence of Hepatocellular Carcinoma After Partial Hepatectomy

Serological Biomarkers and Indices for the Current Activity and Prognosis of ANCA-Associated Vasculitis: Experience in a Single Centre in Korea

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