Preoperative duration of retinal detachment and subretinal immunoreactive endothelin-1: repercussion on logarithmic visual acuity

Abstract

Preoperative RD duration showed statistically significant positive correlations with pre- and with postoperative 8 months LogMAR VAs in both the no-PVR and the PVR groups and with IR-ET-1 measurements (plasma and SRF: lower correlations) only in the no-PVR group. These findings support the idea of doing primary and prompt vitrectomy for RD and perhaps using coadjutant pharmacologic therapy in order to improve visual results.

Cytokine profiles of phakic and pseudophakic eyes with primary retinal detachment

“…; Roldán‐Pallarès et al. ). For example, higher vitreal levels of IL‐6, MIF (macrophage inhibitory factor), and the chemokine ligands CCL2, CCL11, CCL17, CCL18, CCL19, CCL22, CXCL8, CXCL9, and CXCL10 have been reported in eyes with RD and PVR (Ricker et al.…”

Modelling postoperative visual acuity with and without proliferative vitreoretinopathy associated with primary rhegmatogenous retinal detachment

“…SRF was obtained during the drainage procedure of the RD surgery, 23 as previously reported. 18,24 Briefly, after a 1-mm sclerotomy and local diathermic coagulation of the choroids at the site of maximum prominence of the detached retina, a plastic disposable fine-tip transfer pipet (Life Scan Inc., Milpitas, CA, USA) was used to obtain the SRF. Both SRF and blood samples were collected in chilled tubes containing protease inhibitors.…”

“…Both SRF and blood samples were collected in chilled tubes containing protease inhibitors. 6,17,18 Blood samples were centrifuged at 3000 r.p.m. for 20 min at 4 1C to obtain plasma.…”

“…IR-ET-1 measurements were taken from plasma and SRF samples as previously reported. 6,17,18,24 Briefly, IR-ET-1 was assayed in the laboratory by RIA, using polyclonal antibodies against synthetic ET-1 (Peninsula Laboratories, Merseyside, UK) at a 1 : 90 000 final dilution. The sensitivity of the RIA was 1 pg/ml.…”

“…17 In our study, IR-ET-1 levels in the subretinal fluid (SRF) were more strongly associated with PVR (as a complication of RD) than with the preoperative duration of RD. 18 The purpose of this paper was to quantify the influence of several factors in predicting VA (expressed as logMAR) 8 months after surgery in patients who had primary rhegmatogenous RD with or without PVR. Factors analysed in this study included (1) the preoperative duration of RD (in days), (2) the preoperative logMAR of VA, (3) the preoperative ocular haemodynamics (in terms of CRA Doppler parameters), (4) the preoperative IOP, and (5) the ET-1 levels in both plasma and SRF.…”