Preoperative Cervical Cytology in Endometrial Carcinoma and Its Clinicopathologic Relevance

Fukuda, Koichi; Mori, Mitsuru; Uchiyama, Masahiro; Iwai, Kyoko; Iwasaka, Tsuyoshi; Sugimori, Hajime; Yamasaki, Fumio

doi:10.1006/gyno.1998.5244

Cited by 38 publications

(46 citation statements)

References 9 publications

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“…Numerous studies reported the value of other preoperative staging procedures in diagnosing cervical involvement, such as cervical cytology [7,10,12,22], CT scan [23], transvaginal ultrasonography [12,23] and MRI [23,24]. Cervical cytology, CT and transvaginal ultrasonography showed poor results and are not suitable for detecting cervical involvement [7,10,12,22,23].…”

Section: Discussionmentioning

confidence: 99%

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Bijen

Bock

Hoor

et al. 2009

Gynecologic Oncology

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a b s t r a c t a r t i c l e i n f oObjective. The presence of cervical involvement is important to establish a rational treatment for endometrial cancer patients. We investigated the value of preoperative endocervical curettage (ECC) in predicting cervical involvement.Methods. Preoperative ECC of 290 patients with clinical stage I epithelial endometrial cancer was compared with histopathology of the uterus.Results. Amongst all ECCs, 245 (84.5%) were negative and 45 (15.5%) were positive for endometrial cancer. In the uterine specimen, cervical involvement was found in 20% (58/290). PPV and NPV of ECC were 86.7% and 92.2%. False negative and false positive ECC occurred in 6.6% and 2.1%. Of all patients with positive ECC, 46.7% had FIGO stage II disease and 46.7% had extra uterine tumor spread (FIGO III, IV).Conclusion. ECC is an acceptable diagnostic tool to predict the presence or absence of cervical involvement in early stage endometrial cancer patients.

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Section: Discussionmentioning

confidence: 99%

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Bijen

Bock

Hoor

et al. 2009

Gynecologic Oncology

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“…Studies since 1970 have focused predominantly on the potential role of cervical cytology as a predictor of grade, stage, or other clinical parameters (Table 4). 3,18,[22][23][24][25][26][27][28][29][30][31][32][33][34] The sensitivities of those studies range from 20% to 90%. Many report higher sensitivity than we found in the current study; however, in most instances, this well may have resulted from a review of Pap tests by cytologists who were aware of the underlying malignancy, with a concomitant change in the perception of abnormal.…”

Section: Discussionmentioning

confidence: 99%

Liquid-based Papanicolaou test (SurePath) interpretations before histologic diagnosis of endometrial hyperplasias and carcinomas

Thrall¹,

Kjeldahl²,

Gulbahce³

et al. 2007

Cancer

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Silicone‐based additives have been used as fire retardants for thermoplastics and present the advantages of improving the processing and impact resistance of the polymers. In this study, we used three different silicone‐based additives as modifiers of a vinyl ester resin. The additives were fine powders made up of about 50 wt % polydimethylsiloxane and 50 wt % silica. The differences among them were the functional groups inserted in the polymer chains and the size and size distribution of the particles. The additives were dispersed in resin containing 35 wt % styrene. To cure the mixture, a conventional catalyst and initiator were used, and the reaction was carried out in three ways, which differed in the curing temperature, postcuring temperature, time, and addition of dimethylaniline (DMA) as a promoter of the polyaddition reaction. Dynamic mechanical analysis showed that the phase behavior of the resulting composites depended strongly on the curing conditions. The flexural modulus of composites containing 5 wt % additive was lower than that for the cured resin. The impact resistance of the composites also depended on the curing conditions but not on the composition or size of the particle of the additive. The fracture morphologies of specimens subjected to impact resistance tests were different for samples cured in the presence or in the absence of DMA, which suggested that it influenced the mechanism of network formation. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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“…Certain cytomorphologic features are helpful in distinguishing benign and malignant endometrial lesions [32].…”

Section: Discussionmentioning

confidence: 99%

Manual Liquid Based Cytology in Diagnosis of Gynecologic Pathology

Manoli¹

2016

CRJ

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Abnormal uterine bleeding (AUB) is a commonly encountered complaint in gynecology department. Endometrial cancer is the fourth most common malignancy in women and the most frequent gynecological cancer in developed countries. With 5,28, 000 new cases every year, cervical cancer is the fourth most common cancer affecting women worldwide, after breast, colorectal, and lung cancers. Though the cytological examination has been the mainstay for early detection of cervical cancer, and found to be useful in detection of endometrial cancer, its widespread use has not been possible in the developing countries due to paucity of resources, man power and other facilities Its sensitivity reduces to less than 50% when there is presence of obscuring blood, inflammation or thick areas of overlapping epithelial cells. Manual Liquid Based Cytology (MLBC) is a cost effective technique that enables cells to be suspended in a monolayer and thus improve detection of precursor lesions and specimen adequacy. The residual sample can be used for other tests like Cell block and immunocytochemistry. Objectives: 1. To improve the diagnosis of gynecological cancers by a method called as Manual Liquid Based Cytology (MLBC). 2. To study a cost effective method of studying both endometrial and cervical cancer with help of ancillary techniques like cellblock, immunocytochemistry 3To compare the findings between conventional pap smear (CPS) and MLBC in detection of gynecological conditions of endometrium and cervix. Methodology: Samples were collected using Ayres spatula by split sample technique from transformation zone of cervix which included outpatients of gynecology dept. The women were aged between 20-60 years, 82 cases with bleeding history were taken to study endometrial pathology, while 100 cases of white discharge per vagina were selected to study the cervix. 60 cases were later subjected to ancillary studies like cellblock with Immunocytochemistry. Histopathological correlation was done for cases wherever possible. Results: The study on endometruim showed MLBC is more sensitive and specific than CPS in diagnosis of malignant lesions. The contingency coefficient for LBC/Histopathology V/s CPS/Histopathology was 0.572 V/s 0.556. It was observed for cervical lesion that increased detection rate was 150% for low grade intraepithelial lesion. The Positive predictive value for diagnosing neoplastic lesions on cell blocks was 75%, while Concordance Rate of CB/Histopathology Vs CPS/Histopathology was 74% vs. 54%. Conclusion: MLBC is a cost effective method for detections of cancerous lesions of endometruim and cervix.

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Preoperative Cervical Cytology in Endometrial Carcinoma and Its Clinicopathologic Relevance

Cited by 38 publications

References 9 publications

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Liquid-based Papanicolaou test (SurePath) interpretations before histologic diagnosis of endometrial hyperplasias and carcinomas

Manual Liquid Based Cytology in Diagnosis of Gynecologic Pathology

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