Prenatal vitamin D status and offspring’s growth, adiposity and metabolic health: a systematic review and meta-analysis

Santamaria, Christina; Bi, Wei Guang; Leduc, Line; Tabatabaei, Negar; Jantchou, P; Luo, Zhong‐Cheng; Audibert, François; Nuyt, Anne Monique; Wei, Shu Qin

doi:10.1017/s0007114517003646

Cited by 38 publications

(39 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is also possible that VD has an impact on cognitive function throughout the lifespan with a critical window for VD deficiency during pregnancy and early childhood, and only after a long latency period does its impact become more apparent at older ages when cognitive function starts to decline. This goes with the developmental origin of health and disease (DOHaD) paradigm and is supported by studies that showed the link between VD deficiency during pregnancy and various outcomes during childhood or adulthood [ 48 ]. Evidence from animal studies suggest that maternal VD during pregnancy plays a role in the brain development of offspring; however, the association between low maternal VD levels during pregnancy with poor cognition of offspring in humans is inconclusive [ 49 ].…”

Section: Discussionmentioning

confidence: 85%

Plasma 25-Hydroxy Vitamin D Is Not Associated with Either Cognitive Function or Academic Performance in Adolescents

et al. 2018

View full text Add to dashboard Cite

Several observational studies have reported an association between low levels of vitamin D (VD) and poor cognition in adults, but there is a paucity of data on such an association in adolescents. We investigated the association between VD and cognitive function or academic achievement among 1370 adolescents, who were selected from public middle schools in Kuwait, using stratified multistage cluster random sampling with probability proportional to size. Plasma 25-hydroxy VD (25-OH-D) was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). An age-adjusted standard score (ASC), calculated from Raven’s Standard Progressive Matrices test, was used to evaluate cognitive function; academic achievements were extracted from the schools’ records. Data on various covariates were collected from the parents through a self-administered questionnaire and from the adolescents using face-to-face interviews. 25-OH-D was weakly correlated positively with ASC (ρ = 0.06; p = 0.04). Univariable linear regression analysis showed an association between 25-OH-D categories and ASC after adjusting for gender, but adjusting for parental education was sufficient to explain this association. Multivariable analysis showed no association between 25-OH-D and ASC after adjusting for potential confounders whether 25-OH-D was fitted as a continuous variable (p = 0.73), a variable that is categorized by acceptable cutoff points (p = 0.48), or categorized into quartiles (p = 0.88). Similarly, 25-OH-D was not associated with academic performance. We conclude that 25-OH-D is associated with neither cognitive function nor academic performance in adolescents.

show abstract

Section: Discussionmentioning

confidence: 85%

Plasma 25-Hydroxy Vitamin D Is Not Associated with Either Cognitive Function or Academic Performance in Adolescents

et al. 2018

View full text Add to dashboard Cite

show abstract

“…All these effects indicate how important vitamin D is during gestation [50]. Several observational studies show a relationship between inadequate serum 25(OH)D in pregnant women and adverse neonatal and pregnancy outcomes including preeclampsia, small for gestational age (SGA), preterm birth and gestational diabetes mellitus [51].…”

Section: Vitamin Dmentioning

confidence: 99%

“…Currently, there is no universal definition of vitamin D deficiency [51], and the standards for which adequacy levels were established only considered the levels necessary to maintain bone health [12]. In pregnant women, deficiency prevalence (<50 nmol/L) is estimated to be between 40%-60% in the U.S. [113,114], and as high as 54% globally [115].…”

Section: Vitamin Dmentioning

confidence: 99%

“…A recent meta-analysis of observational studies showed an association between vitamin D deficiency and decreased head circumference-for-age at 1 year, but no relationship between deficiency and infant length at 9 months, or weight-for-age at 1 year [51]. The same meta-analysis showed the data is inconclusive for a relationship between vitamin D deficiency and newborn length, length-for-age at 1 year, risk of SGA, newborn head circumference, and onset of type 1 diabetes (T1D) because of inconsistencies between study methods [51].…”

Section: Vitamin Dmentioning

confidence: 99%

See 1 more Smart Citation

Nutritional Gaps and Supplementation in the First 1000 Days

Korczak²,

et al. 2019

View full text Add to dashboard Cite

Optimized nutrition during the first 1000 days (from conception through the 2nd birthday) is critical for healthy development and a healthy life for the newborn. Pregnancy and the postpartum period are accompanied by physiological changes, increased energy needs, and changing requirements in the nutrients critical for optimal growth and development. Infants and toddlers also experience physiological changes and have specific nutritional needs. Food and nutrition experts can provide women of childbearing age with adequate dietary advice to optimize nutrition, as well as guidance on selecting appropriate dietary supplements. Considering the approaching 2020–2025 Dietary Guidelines for Americans (DGA) will be making specific recommendations for children, it is important to provide accurate scientific information to support health influencers in the field of nutrition. The purpose of this review is to summarize the nutrition and supplementation literature for the first 1000 days; to highlight nutritional and knowledge gaps; and to educate nutrition influencers to provide thoughtful guidance to mothers and families. Optimal nutrition during pregnancy through early childhood is critical for supporting a healthy life. Nutrition influencers, such as dietitians, obstetricians/gynecologists, and other relevant health professionals, should continue guiding supplement and food intake and work closely with expectant families and nutrition gatekeepers.

show abstract

“…The American Society of Endocrinology, however, defined deficiency as being lev-els of 25 (OH) D <50 nmol/L (20 ng/mL), insufficiency as between 52.5 and 72.5 nmol/L (21-29 ng/mL) and optimal or adequate levels as >75 nmol/L (>30 ng/mL) (Holick et al, 2011). Regardless of the proposed cut-off points, it has been observed that vitamin D levels <50 nmol/L during pregnancy are associated with an increased risk of preeclampsia (Wei et al, 2013), gestational diabetes (Wei et al, 2013), being small for gestational age (Santamaria et al, 2018;Wei et al, 2013) and preterm infants (Qin, Lu, Yang, Xu, & Luo, 2016;Wei et al, 2013), while levels of 25 (OH) D <30 nmol/L are associated with low birthweight (Santamaria et al, 2018).…”

Section: Vitamin D Status During Pregnancymentioning

confidence: 99%

Vitamin D during pregnancy and neurodevelopment of the child: systematic review.

Villalobos¹,

Tous

Canals

et al. 2019

AN PSICOL-SPAIN

View full text Add to dashboard Cite

Antecedentes: El déficit de vitamina D durante el embarazo tiene un impacto negativo en la salud materno-infantil. Objetivo: Evaluar el efecto del estado de vitamina D durante el embarazo sobre el neurodesarrollo del niño. Selección de estudios: Se realizó una búsqueda de la literatura científica publicada en PubMed/MEDLINE, Scopus y Cochrane hasta enero del 2018. Se seleccionaron los estudios que relacionaban el estado de la vitamina D durante el embarazo con algún dominio del neurodesarrollo del niño (mental, motor, lenguaje, cociente intelectual y comportamiento). La calidad de los estudios incluidos se evaluó a través de la escala Newcastle-Ottawa. Resultados: De los 164 estudios encontrados en la búsqueda, once estudios cumplieron los criterios y fueron considerados diez de alta calidad metodológica y uno de moderada. La revisión sistemática mostró que niveles prenatales de vitamina D <50 nmol/L se asocian frecuentemente a un peor desarrollo mental, motor y del lenguaje de sus hijos en comparación con las madres con concentraciones ≥50 nmol/L. Conclusión: Aunque existe poca evidencia científica que corrobore la relación entre la deficiencia de vitamina D prenatal y su impacto en el neurodesarrollo de los hijos, los datos actuales sugieren un perjuicio sobre el desarrollo mental, motor y del lenguaje del niño. Background: A deficiency of vitamin D during pregnancy has a negative impact on the health of the mother and the child. Objective: To evaluate the effect of vitamin D status during pregnancy on the neurodevelopment of children. Selection of studies: We explored studies that linked the maternal status of vitamin D with neurodevelopment in the infant. The selected studies were identified through a systematic review of the scientific literature published in PubMed/MEDLINE, Scopus and Cochrane until January 2018. The quality of the included studies was carried out through the Newcastle-Ottawa scale. Results: 164 studies were identified and reviewed for selection. At the end of this review, 11 studies were included, all of high methodological quality. This systematic review shows that prenatal vitamin D levels <50 nmol/L are associated with worse mental, motor and language development of their children compared with pregnant women with good vitamin D status. Conclusion: There is still little scientific evidence to corroborate the relationship between prenatal vitamin D deficiency and its impact on the neurodevelopment of children, although current data suggest a detrimental effect on the child's mental, motor and language development.

show abstract

Prenatal vitamin D status and offspring’s growth, adiposity and metabolic health: a systematic review and meta-analysis

Cited by 38 publications

References 63 publications

Plasma 25-Hydroxy Vitamin D Is Not Associated with Either Cognitive Function or Academic Performance in Adolescents

Plasma 25-Hydroxy Vitamin D Is Not Associated with Either Cognitive Function or Academic Performance in Adolescents

Nutritional Gaps and Supplementation in the First 1000 Days

Vitamin D during pregnancy and neurodevelopment of the child: systematic review.

Contact Info

Product

Resources

About