Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics

Possamai-Della, Taise; Cararo, José H.; Aguiar-Geraldo, Jorge M.; Peper-Nascimento, Jefté; Zugno, Alexandra I.; Fries, Gabriel R.; Quevedo, Joao L De; Valvassori, Samira S.

doi:10.1007/s12035-023-03348-1

Cited by 3 publications

(1 citation statement)

References 78 publications

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“…Furthermore， prenatal stress may lead to abnormal methylation levels of genes associated with important pathways of embryogenesis in the placenta, possibly affecting fetal development, as well as the peripheral tissues of the mother and baby ( 23 ). Both animal and human studies have confirmed that epigenetic mechanisms are important modulators of the susceptibility of offspring exposed to stressors during pregnancy to chronic diseases, especially metabolic diseases ( 24 , 25 ). The result of this study conforms to the findings of the Dutch Famine Birth Cohort Study, which observed that kids of pregnant women exposed to famine presented with various characteristics of MetS including obesity, dyslipidaemia, hypertension, and insulin resistance ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of night shift work on metabolic syndrome in adults who suffered from earthquake stress in early life

Wang

et al. 2023

Front. Public Health

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ObjectiveTo examine the role of night shift work on the risk of metabolic syndrome (MetS) in adults suffered from earthquakes prenatally or as infants and to analyse the effect of stress on factors that influence MetS in this population.MethodsWe included 870 subjects from 2014 to 2015. All subjects work as miners for the Kailuan Mining Group and were born were living in Tangshan. Participants were classified into two groups on basis of their work schedules: day shift and night shift. They were further classified into the prenatal exposure group, the infancy exposure group, and the control group based on their age during the Tangshan earthquake. This study was conducted 38 years after the earthquake. Participants’ general demographic data, smoking and drinking habits, as well as work schedules were collected. All participants’ sleep status was assessed with the Pittsburgh Sleep Quality Index. The measurement of all subjects’ waist circumference and blood pressure was made, and triglycerides, fasting blood glucose, high-density lipoproteins, and low-density lipoproteins were measured by collecting blood samples. The definition of MetS was made after the guidelines for preventing and controlling type 2 diabetes in China (2017 Edition).ResultsA total of 187 (21.5%) workers were determined to have MetS. The incidence of MetS was greatly higher in night shift workers who were exposed to an earthquake during infancy than in day shift workers (χ2 = 8.053, p = 0.005). A multivariate logistic regression analysis displayed male participants had a higher risk develop MetS than female participants (p = 0.042, OR = 0.368, 95% CI = 0.140, 0.965). Current smokers (p = 0.030, OR = 1.520, 95%CI = 1.042, 2.218) and participants who sleep fewer than 7 h per night (p = 0.015, OR = 1.638, 95%CI = 1.101, 2.437) had a higher risk of MetS. Prenatal earthquake stress was also a risk element for MetS (p = 0.012, OR = 1.644, 95%CI = 1.115, 2.423).ConclusionThe risk of MetS is significantly higher in night shift workers exposed to earthquake stress during infancy than day shift workers. Earthquake exposure during pregnancy is an independent risk factor for MetS. Smoking and sleeping less than 7 h have a higher risk of MetS than the control group.

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Section: Discussionmentioning

confidence: 99%

Effect of night shift work on metabolic syndrome in adults who suffered from earthquake stress in early life

Wang

et al. 2023

Front. Public Health

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Experimental Design and Behavioral Testing Protocol for the Evaluation of Cognitive Abilities and Social Behavior in Mice Following Early Life Stress

Khafizova,

Naumova,

Lopez

et al. 2024

Современная Зарубежная Психология

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<p style="text-align: justify;">This manuscript presents a protocol designed for the comprehensive investigation of early life stress (ELS) outcomes and a feasibility study conducted with this protocol. ELS alters normal development by interfering at various levels: hormonal changes, brain cellular architecture, epigenome, and chromosomal structural elements. The protocol combines classic behavioral tests with advanced molecular techniques to obtain comprehensive data and thus uncover the underlying mechanisms of ELS. In this protocol, the main source of stress is maternal separation. Briefly, a group of C57Bl/6 mice undergoes maternal separation; then, mice perform the radial maze test and the resident-intruder test. As a control, another group of mice stays undisturbed and performs the same behavioral tests in the same timeframe. After the behavioral tests, biosamples are collected, including urine for corticosterone measurements, peripheral blood, hippocampus, amygdala, and prefrontal cortex tissues for DNA isolation and its downstream analyses (DNA methylation profiling and telomere length measuring), and whole brains for immunohistochemistry analysis of the glucocorticoid receptor density. This protocol was successfully tested as a feasibility study for a large-scale investigation that addresses potential flaws to establish a robust methodology. This paper reports on a comprehensive approach to examining multiple aspects of development that interrogates a holistic analysis of multilayer and multidimensional data and may contribute valuable insights for both animal and human studies.</p>

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Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

Scuto,

Rampulla,

Reali

et al. 2024

Antioxidants

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The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience and overall human health have received much attention. Recently, the gut–brain axis has attracted prominent interest for preventing and therapeutically impacting neuropathologies and gastrointestinal diseases. Polyphenols and polyphenol-combined nanoparticles in synergy with probiotics have shown to improve gut bioavailability and blood–brain barrier (BBB) permeability, thus inhibiting the oxidative stress, metabolic dysfunction and inflammation linked to gut dysbiosis and ultimately the onset and progression of central nervous system (CNS) disorders. In accordance with hormesis, polyphenols display biphasic dose–response effects by activating at a low dose the Nrf2 pathway resulting in the upregulation of antioxidant vitagenes, as in the case of heme oxygenase-1 upregulated by hidrox® or curcumin and sirtuin-1 activated by resveratrol to inhibit reactive oxygen species (ROS) overproduction, microbiota dysfunction and neurotoxic damage. Importantly, modulation of the composition and function of the gut microbiota through polyphenols and/or probiotics enhances the abundance of beneficial bacteria and can prevent and treat Alzheimer’s disease and other neurological disorders. Interestingly, dysregulation of the Nrf2 pathway in the gut and the brain can exacerbate selective susceptibility under neuroinflammatory conditions to CNS disorders due to the high vulnerability of vagal sensory neurons to oxidative stress. Herein, we aimed to discuss hormetic nutrients, including polyphenols and/or probiotics, targeting the Nrf2 pathway and vitagenes for the development of promising neuroprotective and therapeutic strategies to suppress oxidative stress, inflammation and microbiota deregulation, and consequently improve cognitive performance and brain health. In this review, we also explore interactions of the gut–brain axis based on sophisticated and cutting-edge technologies for novel anti-neuroinflammatory approaches and personalized nutritional therapies.

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Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics

Cited by 3 publications

References 78 publications

Effect of night shift work on metabolic syndrome in adults who suffered from earthquake stress in early life

Effect of night shift work on metabolic syndrome in adults who suffered from earthquake stress in early life

Experimental Design and Behavioral Testing Protocol for the Evaluation of Cognitive Abilities and Social Behavior in Mice Following Early Life Stress

Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

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