Prenatal multivitamins containing folic acid do not decrease prevalence of depression among pregnant women

Cho, Y. J.; Han, Ji Yoon; Choi, June Seek; Ahn, Hyun Kyong; Ryu, Hyun-Mee; Kim, M. Y.; Yang, Jae Hyug; Nava-Ocampo, Alejandro A; Koren, Gideon

doi:10.1080/01443610802196658

Cited by 22 publications

(17 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients receiving the active treatment had significantly lowered Hamilton Rating Scale for Depression (HAM-D) scores and significantly higher rates of response and remission at weeks 6 and 8. In Korea, Cho et al31 utilized a questionnaire format with 1,314 pregnant women. This group found a trend for Folic Acid (FA) and Multivitamins (MVA) protecting against AD, but the relationship was not statistically significant.…”

Section: Resultsmentioning

confidence: 99%

Antenatal Depression in East Asia: A Review of the Literature

Schatz

Hsiao

Liu

2012

Psychiatry Investig

View full text Add to dashboard Cite

This current study's goal is to summarize the literature regarding Antenatal Depression (AD) in the East Asian countries of Taiwan, China (including Hong Kong and Macau), Japan, and Korea. The main search utilized a Pub med Chinese Electronic Periodical Service (CEPS) literature review using keywords 'AD', and 'Prenatal Depression' with searches for 'Japan', 'Korea', 'Taiwan', 'Hong Kong' and Macau'. The rates of AD in East Asia appear to be relatively close to those in the Western literature, although certain studies showed slightly decreased rates. Many of the risk factors for AD were the same in the Eastern and Western literature. These risk factors included demographic factors such as younger age, smoking, low education and income, and unemployment. Other risk factors were physical symptoms such as menstrual pains and nausea. Finally, psychological factors such as a poor response to the pregnancy, poor spousal support, and poor family support were associated with AD. With regard to treatment, there were no studies examining the administration of psychotropic medications for AD. The literature from East Asia both confirmed many Western findings and made unique contributions to the literature on AD. The treatment of AD in East Asia appears to be an entity which, despite its morbidity, has not been adequately studied.

show abstract

Section: Resultsmentioning

confidence: 99%

Antenatal Depression in East Asia: A Review of the Literature

Schatz

Hsiao

Liu

2012

Psychiatry Investig

View full text Add to dashboard Cite

show abstract

“…This prospective cohort study of 865 pregnant women found no evidence of an association; however, the number of women classified as depressed was relatively small (14%) considering that a threshold of 9 or more on the Edinburgh Postnatal Depression Scale (EPDS) was used, and folic acid supplementation was not included in the analysis (Miyake et al, 2006). Cho et al (2008) investigated whether intake of prenatal multivitamins containing folic acid was associated with decreased rates of depression among 1277 pregnant women. The overall prevalence of depression was 9.4% among those taking multivitamins and 6.9% among those not taking multivitamins, but the study did not show strong evidence of an effect (P ¼ 0.11).…”

Section: Introductionmentioning

confidence: 99%

Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype

et al. 2011

View full text Add to dashboard Cite

Background/Objectives: As low folate status has been implicated in depression, high folate intake, in the form of supplements, during pregnancy might offer protection against depression during pregnancy and postpartum. Subjects/Methods: We examined the association between change in self-reported depressive symptoms (Edinburgh Postnatal Depression Scale) at different timepoints during and following pregnancy and self-reported folic acid supplementation during pregnancy in a prospective cohort of 6809 pregnant women. We also tested whether there was a main effect of methylenetetrahydrofolate reductase (MTHFR) C677T genotype (which influences folate metabolism and intracellular levels of folate metabolites and homocysteine) on change in depression scores, and carried out our analysis of folic acid supplementation and depression stratifying by genotype. Results: We found no strong evidence that folic acid supplementation reduced the risk of depression during pregnancy and up to 8 months after pregnancy. However, we did find evidence to suggest that folic acid supplements during pregnancy protected against depression 21 months postpartum, and that this effect was more pronounced in those with the MTHFR C677T TT genotype (change in depression score from 8 months to 21 months postpartum among TT individuals was 0.66 (95% CI ¼ 0.31-1.01) among those not taking supplements, compared with À1.02 (95% CI ¼ À2.22-0.18) among those taking supplements at 18 weeks pregnancy, P difference ¼ 0.01). Conclusions: Low folate is unlikely to be an important risk factor for depression during pregnancy and for postpartum depression, but may be a risk factor for depression outside of pregnancy, especially among women with the MTHFR C677T TT genotype.

show abstract

“…Differences in depression screening tool (Kessler Psychological Distress Scale versus EPDS) and time of sample collection (antepartum versus postpartum) may explain the divergent results observed in the two studies. Other signi cant studies exploring the association between B-vitamin and PPD measured only dietary intake of folate, vitamin B6 and B12 (25) or supplementation (26)(27)(28) without measuring the circulating levels of vitamin B12 (29)(30)(31) . We conducted a pilot study to observe the status of vitamin B12, total folate and hcy in 24-48 hours post delivery, and found higher hcy levels in depressed women when compared to the non-depressed.…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Dhiman

Pillai

Wilson

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundVitamin B12 is an essential micronutrient for neurological function, as it leads to the regeneration of methionine from homocysteine, which is precursor of biologically active molecule SAM. Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression. MethodsWomen attending postpartum clinic at 6 weeks post-delivery were screened for the presence of depressive symptoms using Edinburg postpartum depression scale (EPDS). Based on a cut-off of 10, two groups were taken- women with probable depression with EPDS score>10 (n=217) and women without probable depression with EPDS score<10(n=217). Plasma total vitamin B12, holotranscobalamin, homocysteine, MMA, 5-methyl THF, SAM and serotonin levels were estimated using commercially available ELISA kits. Combined B12(cB12) score was calculated and analysis of resulting data was done using SPSS ver20.0. ResultsTotal vitamin B12 was significantly lower (p=0.001) and MMA (p=0.002) and 5-methyl THF(p<0.001) levels were higher in women with probable depression than women without probable depression. Combined B12 index was also lower in women with probable PPD (p=0.001). Women in the lowest vitamin B12 quartile had 4.53 times higher likelihood of probable postpartum depression (p < 0.001). Decreasing vitamin B12 (OR = 0.394; 95% CI: 0.189-0.822) and cB12 (OR=0.293; 95% CI:0182-0.470) and increasing MMA (OR = 2.14; 95% CI: 1.63-2.83) and 5-methyl THF levels (OR = 3.29; 95% CI: 1.59-6.83) were significantly associated with the risk of PPD.ConclusionLow vitamin B12 may contribute to depressive symptoms in vulnerable postpartum period.

show abstract

Prenatal multivitamins containing folic acid do not decrease prevalence of depression among pregnant women

Cited by 22 publications

References 12 publications

Antenatal Depression in East Asia: A Review of the Literature

Antenatal Depression in East Asia: A Review of the Literature

Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Contact Info

Product

Resources

About