Prenatal hypoxia–ischemia decreases spatial memory and increases aggression during adolescence

Indriawati, Ratna; Aswin, Soedjono; Susilowati, Rina; Partadiredja, Ginus

doi:10.1556/2060.105.2018.3.21

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…At the current stage of the development of morphology and clinical medicine, the interest in vegetative nodes, which are complex peripheral nerve centers connected to the central nervous system and are trophic and communication and distribution centers, does not decrease [1,2,3,4].…”

Section: Introductionmentioning

confidence: 99%

Morphological Characteristics of the Pineal Gland of Newborn Rats Under Conditions of Chronic Prenatal Hypoxia

Pshychenko,

Cherno,

Chebotar

et al. 2024

VPBM

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Connection of the publication with planned research works.The present work is part of the research topic of the Department of Anatomy, Clinical Anatomy, Operative Surgery, Pathomorphology and Forensic Medicine of the Petro Mohyla Black Sea National University of the Ministry of Education and Culture of Ukraine «Role of ecologically hazardous factors in the development of diseases of civilization», state registration number 0120U002026.Introduction.Prenatal ontogeny is a period of high sensitivity to the influence of stress factors, so any stressor can lead to changes in morpho-functional, biochemical indicators, behavioral and cognitive functions of the body. The most common and clinically significant stress factor to which the embryo can be exposed is hypoxia. Prenatal hypoxia during critical periods of brain formation leads to significant pathological changes at various stages of postnatal life in the development of cognitive functions, neurological disorders, behavioral disorders and learning abilities, which correlate with morphological changes in brain structures involved in learning and memory. which is the most common cause of death and disability [1, 2, 3 ,4]. Prenatal hypoxia also leads to pathologies of the neuroendocrine system, which are accompanied by a violation of the processes of synthesis and secretion of neurohormones, dysfunction of the pineal gland, and a decrease in the adaptation potential [2,5,6]. Therefore, the problem of prenatal hypoxia and its remote conse-

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Section: Introductionmentioning

confidence: 99%

Morphological Characteristics of the Pineal Gland of Newborn Rats Under Conditions of Chronic Prenatal Hypoxia

Pshychenko,

Cherno,

Chebotar

et al. 2024

VPBM

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“…Hypoxia is associated with immunity [4], [5], [6], cognitive [7], [8], motor, and behavioral aspects [4], [9], [10]. One form of immune response is the level of tumor necrosis factor-α (TNF-α) [11], [12].…”

Section: Introductionmentioning

confidence: 99%

An Increase in TNF-α Levels in Fetus due to Prenatal Ischemic Hypoxia

Indriawati

Risdiana

Wibowo

2021

Open Access Maced J Med Sci

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BACKGROUND: Prenatal ischemic hypoxia can increase mortality and morbidity and affect the immune system. One of the immune responses is tumor necrosis factor-α (TNF-α) levels. However, the cellular mechanism of immune response abnormalities due to prenatal hypoxia remains unclear. An 11–17-day-old fetus is a sensitive period of neural development. Brain ischemia will cause cell dysfunction and can even affect TNF-α levels. Thus, how prenatal ischemic hypoxia increases TNF-α levels in the fetus remains unclear. AIM: This study aims to examine the effect of the onset and duration of prenatal ischemic hypoxia on TNF-α levels. METHODOLOGY: An experimental study with a post-test control design was conducted. Thirty Rattus norvegicus were induced with prenatal ischemic hypoxia (embryos aged 7, 12, and 17 days). The independent variable was prenatal ischemic hypoxia, while the dependent variable was TNF-α levels. TNF-α was measured using the ELISA technique and was carried out when the fetus was 19 days old (E19). The TNF-α was analyzed using ANOVA, and the limit of significance was set at p < 0.05. RESULTS: The TNF-α levels in the prenatal ischemic hypoxia group were statistically higher than in the control group (p < 0.05). The more the onset and the longer the ischemic hypoxia is, the higher the TNF-level (p < 0.05). CONCLUSION: The prenatal ischemic hypoxia increased TNF-α levels in the fetus.

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