Prenatal Food Restriction Induces a Hypothalamic-Pituitary-Adrenocortical Axis-associated Neuroendocrine Metabolic Programmed Alteration in Adult Offspring Rats

Zhang, Li; Xu, Dan; Zhang, Benjian; Chu, Fenglong; Guo, Yuming; Gong, Jun; Zheng, Xiaona; Chen, Liaobin; Wang, Hui

doi:10.1016/j.arcmed.2013.07.006

Cited by 38 publications

(31 citation statements)

References 70 publications

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“…The standard rodent chow purchased from the Experimental Centre of Hubei Medical Scientific Academy contained 21% kcal from protein, 68.5% kcal from carbohydrate and 10.5% kcal from fat. The HFD used previously reported by our laboratory [25] and contained 88.0% corn flour, 11.5% lard, and 0.5% cholesterol, which provided 18.9% kcal from protein, 61.7% kcal from carbohydrates and 19.4% kcal from fat. The groups were named as follows: MVN, male with vehicle and normal diet; MEN, male with PEE and normal diet; MVH, male with vehicle and HFD; MEH, male with PEE and HFD; FVN, female with vehicle and normal diet; FEN, female with PEE and normal diet; FVH, female with vehicle and HFD; and FEH, female with PEE and HFD.…”

Section: Methodsmentioning

confidence: 99%

Effects and Interactions of Prenatal Ethanol Exposure, a Post-Weaning High-Fat Diet and Gender on Adult Hypercholesterolemia Occurrence in Offspring Rats

Qi¹,

Luo²,

Hu³

et al. 2017

Cell Physiol Biochem

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Background/Aims: Prenatal ethanol exposure (PEE) could induce intrauterine programming of hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolism, resulting in intrauterine growth retardation and susceptibility to adult hypercholesterolemia in offspring. This study aimed to analyse the effects and interactions of PEE, a post-weaning high-fat diet (HFD) and gender on the occurrence of adult hypercholesterolemia in offspring rats. Methods: Wistar female rats were treated with ethanol (4 g/kg.d) at gestational days 11-20. The offspring were given a normal diet or HFD after weaning, and the blood cholesterol metabolism phenotype and expression of hepatic cholesterol metabolism related genes were detected in 24-week-old offspring. Furthermore, the interactions among PEE, HFD, and gender on hypercholesterolemia occurrence were analysed. Results: PEE increased the serum total cholesterol (TCH) and low-density lipoprotein-cholesterol (LDL-C) levels and decreased the serum high-density lipoprotein-cholesterol (HDL-C) level in adult offspring rats; the changes in female offspring were greater than those in males. At the same time, the mRNA expression levels of hepatic cholesterol metabolic enzymes (apolipoprotein B (ApoB) and 7α-hydroxylase (CYP7A1))—were increased, while the mRNA expression levels of the scavenger receptor B1 (SR-B1) and LDL receptor (LDLR) were decreased. Furthermore, a three-way ANOVA showed there were interactions among PEE, post-weaning HFD and gender. For PEE offspring, a post-weaning HFD aggravated the elevated hepatic ApoB and CYP7A1 expression and reduced SR-B1 and LDLR expression; the changes in hepatic SR-B1 and CYP7A1 expression were greater in female HFD rats than in males. Conclusion: Our findings suggest that a post-weaning HFD could aggravate offspring hypercholesterolemia caused by PEE and that this mechanism might be associated with hepatic cholesterol metabolic disorders that are aggravated by a post-weaning HFD; hepatic cholesterol metabolism was more sensitive to neuroendocrine metabolic alterations by PEE and a post-weaning HFD in the female offspring than in the male offspring.

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Section: Methodsmentioning

confidence: 99%

Effects and Interactions of Prenatal Ethanol Exposure, a Post-Weaning High-Fat Diet and Gender on Adult Hypercholesterolemia Occurrence in Offspring Rats

Qi¹,

Luo²,

Hu³

et al. 2017

Cell Physiol Biochem

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“…We also confirmed that prenatal food-restriction (PFR) can induce lower birth weight and altered glucose/lipid metabolism by the programmed alteration of the HPA axis-associated neuroendocrine metabolism (24) . Therefore, IUGR in offspring increases the risk of adult hyperlipidaemia and may be responsible for the IUGR-induced poor quality of articular cartilage.…”

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confidence: 51%

“…All pups were weaned to an ad libitum HFD before being killed on PW24. The HFD was previously reported by our laboratory (24) and provided 18·9 % of its energy content as protein, 61·7 % as carbohydrate and 19·4 % as fat. The body weights of the rat offspring were measured weekly.…”

Section: Animals and Treatmentmentioning

confidence: 99%

Prenatal food restriction induces poor-quality articular cartilage in female rat offspring fed a post-weaning high-fat diet and its intra-uterine programming mechanisms

Tan

et al. 2016

Br J Nutr

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Epidemiological data show that osteoarthritis (OA) is significantly associated with lower birth weight, and that OA may be a type of fetaloriginated adult disease. The present study aimed to investigate the prenatal food-restriction (PFR) effect on the quality of articular cartilage in female offspring to explore the underlying mechanisms of fetal-originated OA. Maternal rats were fed a restricted diet from gestational day (GD) 11 to 20 to induce intra-uterine growth retardation. Female fetuses and female adult offspring fed a post-weaning high-fat diet were killed at GD20 and postnatal week 24, respectively. Serum and knee cartilage samples from fetuses and adult female offspring were collected and examined for cholesterol metabolism and histology. Fetal serum corticosterone and insulin-like growth factor-1 (IGF-1) in the PFR group were lower than those of the control, but the serum cholesterol level was not changed. The lower expression of IGF-1 in the PFR group lasted into adulthood. The expression of extracellular matrix (ECM) genes, including type II collagen, aggrecan and cholesterol efflux genes including liver X receptor, were significantly induced, but the ATP-binding-cassette transporter A1 was unchanged. PFR could induce a reduction in ECM synthesis and impaired cholesterol efflux in female offspring, and eventually led to poor quality of articular cartilage and OA.

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“…Behavioral tests were performed between 09:30 am and 15:30 pm. Blood samples were collected from the caudal vein after the rats were made to fast for 12 h. The rats in the CMS and CMS + HFD groups were subjected to CMS from PW9-12 according to the procedure described in a previous study (23). This included food and water deprivation for 24 h, pinching of the tail (2 cm from the tail end) for 5 min, treatment with heat at 45˚C for 5 min, swimming in cold water at 4-8˚C for 4 min followed by towel drying, reversal of the day and night cycles and social isolation (single rat per cage) for 24 h. The stressors were randomly administered and continuously applied at day and night.…”

Section: Animals and Treatmentmentioning

confidence: 99%

“…On postnatal week (PW) 4, the pups were separated from their mothers, and 16 female pups (2 female pups from each mother) were assigned to each group. One group was fed a normal diet (21% kcal from protein, 68.5% kcal from carbohydrates and 10.5% kcal from fat) and the other group received a HFD (88.0% corn flour, 11.5% lard and 0.5% cholesterol, which provided 18.9% kcal from protein, 61.7% kcal from carbohydrates and 19.4% kcal from fat) (23). The HFD and control groups were then further subdivided into two subgroups each (n=8 in each): One subgroup of each group was subjected to 21 days of CMS from PWs 9-12, while the second subgroup was not subjected to stress.…”

Section: Animals and Treatmentmentioning

confidence: 99%

Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

Yang

Qian

2017

Experimental and Therapeutic Medicine

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Abstract.A high-fat diet (HFD) is highly correlated to obesity, metabolic diseases and certain behavioral changes. However, the effects of post-weaning HFD in rats during puberty and the role of the hypothalamic-pituitary-adrenal (HPA) axis in this process have remained elusive. The present study hypothesized that the HPA axis mediates the behavioral alterations induced by a post-weaning HFD. To investigate this, female rats were divided into two groups, one of which was fed a HFD from postnatal weeks (PWs) 4-12, while the other group received standard chow. Rats in each group were then subdivided into two subgroups each, and from PW 9-12, animals from one of the two subgroups were subjected to chronic mild stress (CMS), while the other subgroup received no stress. At PW 12, the body weight of rats receiving a HFD but no DMS was significantly higher than that in the control group. The frequency of crossing and rearing in the open field test and the time in the center of the Y-maze were decreased following CMS. Total time to escape was decreased in rats receiving HFD and after CMS. The serum levels of adrenocorticotropic hormone and corticosterone were increased in rats receiving an HFD and after CMS, and the mRNA levels of corticotropin-releasing hormone and arginine vasopressin in the hypothalamus were increased in the HFD + CMS group compared to that in the control group. The mRNA expression of glucocorticoid receptor (GR) in the hippocampi of rats in the HFD + CMS group was significantly decreased and the mineralocorticoid receptor/GR ratio was increased compared to that in the groups receiving either CMS or a HFD. In conclusion, these results indicated that female rats fed a post-weaning HFD showed HPA axis hypersensitivity under CMS, which may mediate behavioral alterations.

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Prenatal Food Restriction Induces a Hypothalamic-Pituitary-Adrenocortical Axis-associated Neuroendocrine Metabolic Programmed Alteration in Adult Offspring Rats

Cited by 38 publications

References 70 publications

Effects and Interactions of Prenatal Ethanol Exposure, a Post-Weaning High-Fat Diet and Gender on Adult Hypercholesterolemia Occurrence in Offspring Rats

Effects and Interactions of Prenatal Ethanol Exposure, a Post-Weaning High-Fat Diet and Gender on Adult Hypercholesterolemia Occurrence in Offspring Rats

Prenatal food restriction induces poor-quality articular cartilage in female rat offspring fed a post-weaning high-fat diet and its intra-uterine programming mechanisms

Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

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