Prenatal Development of Hematopoietic and Hormone-Producing Cells in the Chicken Adenohypophysis

Allaerts, Wilfried; Boonstra-Blom, A.G.; Peeters, Kristel; Janse, E.M.; Berghman, Lr; Jeurissen, S.H.M.

doi:10.1006/gcen.1998.7235

Cited by 22 publications

(30 citation statements)

References 36 publications

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“…In contrast, administration of granulocyte-macrophage colony-stimulating factor, known to stimulate transition from monocytes into DC (74), to the BM-recipient mice in the absence of GCV treatment increased the number of mac-1 þ and MOMA1 þ cells in the mouse pituitaries compared with control mice (67). In embryonic chicken pituitaries, another early macrophage marker (CVI-ChNl-68.1) (75) was found with a similar tissue distribution and developmental pattern as observed for mac-1 in the mouse (68). CVI-ChNl-68.1 þ macrophages were infiltrating the anterior pituitary of the chick well before full maturation of the pituitary, and also before mature DC (MHC-class II þ ) and FS cells (S-100 þ ) were observed in the pituitary (68) (Fig.…”

Section: Immunophenotype and Embryological Originmentioning

confidence: 88%

“…The relationship between DC and other cell types of the mononuclear phagocyte system such as monocytes and macrophages and their occurrence in the pituitary has been reviewed in (7). Co-localization studies of markers for DC, such as the major histocompatibility complex (MHC)-class II antigen, and the marker for FS cells (S-100) yielded some important findings: (a) using double immunolabeling at the electron-and lightmicroscopic level, cells expressing both S-100 and MHC-class II antigen were found, but co-expression occurred only in 10 -20% of the S-100 þ cells (6) (a proportion remarkably similar to the one expressing iNOS after activation by IFN-g (20)) and (b) the expression of both S-100 (65,66) and MHC-class II antigen did not occur before the postnatal age of 2 weeks in rats (67) or in the chick at hatching (68).…”

Section: Embryological Origin Of Fs Cells and Functional Implicationsmentioning

confidence: 99%

“…1, middle column). To conclude, although no final proof for a BM origin of DC or FS cells in the anterior pituitary of adult rats and mice was found, the search for a possible hematopoietic precursor led to the discovery of BM-derived, early macrophage differentiation antigen-expressing cells, both in the adult mouse (67) and in the embryonic chicken adenohypophysis (68).…”

Section: Immunophenotype and Embryological Originmentioning

confidence: 99%

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History and perspectives of pituitary folliculo-stellate cell research

Allaerts¹,

Vankelecom²

2005

eur j endocrinol

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157

129

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Historically, the study of folliculo-stellate (FS) cells of the anterior pituitary dates back to the onset of electron microscopical observation of the pituitary gland. The morphological and electrophysiological characteristics, topographical distribution and contribution to intercellular junctions of these FS cells have been instrumental to the understanding of their putative function. Moreover, many studies have documented the role of FS cells as a source of newly discovered peptides, growth factors and cytokines. Quantitative immunohistochemical observation of FS cells in situ and functional in vitro studies, using either cultured FS cells or cells from an immortalized FS cell line, forwarded the notion of immunophenotypical and functional heterogeneity of the FS cell group. Double immunolabeling with a classical FS cell marker (S-100 protein) and with major histocompatibility complex class II markers characteristic for dendritic cells (DC) have shown a considerable overlap of FS cells with DC. The latter cells are immunocompetent cells belonging to the mononuclear phagocyte system. In this review, the FS cell heterogeneity is discussed with respect to the question of their embryological origin and developmental fate and with respect to the physiological relevance of functionally heterogeneous subpopulations. Recent findings of a myeloid origin of part of the interstitial cells of the anterior pituitary are confronted by other developmental paradigms of pituitary cell differentiation. The possibility that FS cells represent an adult stem cell population of the pituitary is critically examined. Also the physiological role of FS cells in the interferon-g-and nitric oxide-mediated effects on pituitary hormone secretion is discussed. New approaches for the study of this enigmatic cell group using immortalized cell lines and new markers for an hitherto unrecognized pituitary cell population, the so-called 'side population', are evaluated.

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Section: Immunophenotype and Embryological Originmentioning

confidence: 88%

Section: Embryological Origin Of Fs Cells and Functional Implicationsmentioning

confidence: 99%

Section: Immunophenotype and Embryological Originmentioning

confidence: 99%

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History and perspectives of pituitary folliculo-stellate cell research

Allaerts¹,

Vankelecom²

2005

eur j endocrinol

Self Cite

157

129

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“…However, developmental changes in circulating hormone levels are not merely the result of the functional differentiation and growth of their respective production sites, but also of Using a homologous antibody to chicken TSH, Nakamura and colleagues (2004) found the first thyrotropic cells on embryonic day 10, but TSH mRNA -determined by RT-PCR -was expressed somewhat earlier, on day 9. ACTH-immunopositive cells were detected from day 7 onwards (Sasaki et al, 2003), although immunostaining with a homologous antibody to the ACTH precursor peptide pro-opiomelanocortin (POMC) showed no corticotropic cells at this age (Allaerts et al, 1999). …”

Section: Differentiation Of the Pituitary Glandmentioning

confidence: 99%

“…ACTH-immunopositive cells were detected from day 7 onwards (Sasaki et al, 2003), although immunostaining with a homologous antibody to the ACTH precursor peptide pro-opiomelanocortin (POMC) showed no corticotropic cells at this age (Allaerts et al, 1999). Data on the appearance of growth hormone (GH)-and prolactin-immunoreactive cells in the chicken pituitary are again inconsistent, but most studies do show that the somatotropes and lactotropes are the last pituitary cell types to differentiate (Sasaki et al, 2003).…”

Section: Differentiation Of the Pituitary Glandmentioning

confidence: 99%

The chicken embryo as a model for developmental endocrinology: Development of the thyrotropic, corticotropic, and somatotropic axes

Groef

Grommen

Darras

2008

Molecular and Cellular Endocrinology

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 37A c c e p t e d M a n u s c r i p t A c c e p t e d M a n u s c r i p t 3 The chick as a traditional model for developmental endocrinologyFor more than 2 millennia, the chicken has been a popular animal model to study embryology and developmental biology (Stern, 2005). This is due to some intrinsic advantages that the chicken embryo offers in comparison with mammalian embryonic models. Fertilized chicken eggs are low in cost and in abundant supply, and the chicken embryo is quite large and easily accessible during its entire amniotic development (Murphy & Clark, 1990). Simply by putting a number of fertilized eggs in the incubator, hundreds to thousands of embryos with a more or less synchronized development can be obtained. Furthermore, as the only endocrine connection with the mother is through hormone deposits in the egg yolk, avian embryonic development is relatively independent of changes in maternal physiology that occur after deposition of the egg, which is particularly interesting in view of endocrinological manipulations. The simplicity of direct manipulation of the embryonic endocrine interior without triggering maternal interference makes the chicken embryo a valuable model for the study of development and function of hormonal systems (Decuypere et al., 1990;Jenkins & Porter, 2004). As such, the chicken embryo is used as a model to study the cellular and subcellular differentiation and maturation of endocrine glands, ontogenic changes in the sensitivity or responsiveness of the glands and their target organs, and the development of top-down and bottom-up regulatory systems (Scanes et al., 1987). In general, the control and function of the endocrine axes are similar in birds and mammals. It should be noted, however, that the development of some endocrine systems, especially the thyroidal axis, differs considerably between precocial and altricial species. On the one hand, this limits the generalizability of the Page 4 of 37 A c c e p t e d M a n u s c r i p t 4 chicken embryo model to other avian speci...

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Effects of hydrocortisone on the formation of gap junctions and the abnormal growth of cilia within the rat anterior pituitary gland: Possible role of gap junctions on the regulation of cell development

Sakuma¹,

Soji²,

Herbert³

2001

Anat. Rec.

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We investigated the effects of hydrocortisone on the formation of gap junctions in and the growth of cilia on folliculo‐stellate cells. The male rats of experimental groups were given daily intraperitoneal injections of 5 mg/kg of hydrocortisone from Day 20 to 60. Five rats were killed at ages 10, 20, 30 and 40 days after initiation of injections, and the pituitary gland was removed from each rat. Then, the specimens were prepared for observation by transmission electron microscopy. A delay in the formation of gap junctions between folliculo‐stellate cells was observed in hydrocortisone treated rats compared with control rats on Day 30, 40 and 50. Another finding in the present study was the increase of ciliated follicles on Day 40 and 50 in the hydrocortisone treated groups, simultaneous with the delay in gap junction formation. The results suggest that hydrocortisone has a suppressive effect on the gap junction formation between folliculo‐stellate cells, and loss of intercellular communication by way of gap junctions may lead to alteration of morphological development of the cell. Anat Rec 262:169–175, 2001. © 2001 Wiley‐Liss, Inc.

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Prenatal Development of Hematopoietic and Hormone-Producing Cells in the Chicken Adenohypophysis

Cited by 22 publications

References 36 publications

History and perspectives of pituitary folliculo-stellate cell research

History and perspectives of pituitary folliculo-stellate cell research

The chicken embryo as a model for developmental endocrinology: Development of the thyrotropic, corticotropic, and somatotropic axes

Effects of hydrocortisone on the formation of gap junctions and the abnormal growth of cilia within the rat anterior pituitary gland: Possible role of gap junctions on the regulation of cell development

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