Prenatal complications are associated with the postnatal airway host response and microbiota in intubated preterm infants

Wagner, Brandie D.; Sontag, Marci K.; Harris, J. Kirk; Miller, Josh; Morrow, Lindsey A.; Robertson, Charles E.; Stephens, Mark; Poindexter, Brenda B.; Mourani, Peter M.

doi:10.1080/14767058.2017.1407310

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…Emerging data have highlighted that diverse microbial populations inhabit the respiratory tract, previously considered a sterile compartment [71]. A recent clinical trial examining tracheal aspirates of 71 mechanically ventilated preterm newborns showed important associations between antenatal events, the host airway immune response and airway microbiota [72]. A recent meta-analysis showed that Ureaplasma species colonization was significantly associated with the development of BPD, a chronic lung disease of prematurity leading to life-long limitations in lung function [73].…”

Section: Neonatal Dysbiosis and Consequences For The Premature Infmentioning

confidence: 99%

Dysbiosis and Prematurity: Is There a Role for Probiotics?

et al. 2019

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Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.

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Section: Neonatal Dysbiosis and Consequences For The Premature Infmentioning

confidence: 99%

Dysbiosis and Prematurity: Is There a Role for Probiotics?

et al. 2019

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“…The airway of the preterm infant is not sterile at birth and its microbiome is highly influenced by the microbiome of the amniotic fluid. Differences in colonization and clinical parameters allow the categorization into disease clusters, which are predictive for the clinical course and outcome [ 64 ]. Reduced microbial diversity at birth, initial abundance of ureaplasma species in tracheal aspirates of ventilated preterm infants, and more pronounced changes in the longitudinal microbial community are associated with higher severity of BPD.…”

Section: Microbiota Of the Airways And Bronchopulmonary Dysplasiamentioning

confidence: 99%

The Microbiome and Preterm Birth: A Change in Paradigm with Profound Implications for Pathophysiologic Concepts and Novel Therapeutic Strategies

Staude

Oehmke

Lauer

et al. 2018

BioMed Research International

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Preterm birth poses a global challenge with a continuously increasing disease burden during the last decades. Advances in understanding the etiopathogenesis did not lead to a reduction of prematurely born infants so far. A balanced development of the host microbiome in early life is key for the maturation of the immune system and many other physiological functions. With the tremendous progress in new diagnostic possibilities, the contribution of microbiota changes to preterm birth and the acute and long-term sequelae of prematurity have come into the research focus. This review summarizes the latest advances in the understanding of microbiomes in the amniotic cavity and the female lower genital tract and how changes in microbiota structures contribute to preterm delivery. The exhibition of these highly vulnerable infants to the hostile environment in the neonatal intensive care unit necessarily entails the rapid colonization with a nonbalanced microbiome in a situation where the organism is still very prone and at an early stage of development. The global research efforts to decipher pathologic changes will pave the way to new pre- and postnatal therapeutic concepts.

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“…An interesting study by Wagner et al [ 35 ] assessed the airway response in mechanically ventilated preterm infants by examining 12 proteins in tracheal aspirates collected at 7 days of age. Infants were categorized into three clusters based on protein profiles: Cluster 1 had high levels of most proteins, Cluster 2 showed a mix of high proinflammatory and low anti-inflammatory proteins, and Cluster 3 had low levels of all proteins.…”

Section: Resultsmentioning

confidence: 99%

Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence

Colombo,

Nava,

Castoldi

et al. 2024

Nutrients

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The aim of this scoping review was to investigate and synthesize existing evidence on the airway microbiome of preterm infants to outline the prognostic and therapeutic significance of these microbiomes within the preterm population and identify gaps in current knowledge, proposing avenues for future research. We performed a scoping review of the literature following the Arskey and O’Malley framework. In accordance with our inclusion criteria and the intended purpose of this scoping review, we identified a total of 21 articles. The investigation of the airway microbiome in preterm infants has revealed new insights into its unique characteristics, highlighting distinct dynamics when compared to term infants. Perinatal factors, such as the mode of delivery, chorioamnionitis, the respiratory support, and antibiotic treatment, could impact the composition of the airway microbiome. The ‘gut–lung axis’, examining the link between the lung and gut microbiome as well as modifications in respiratory microbiome across different sites and over time, has also been explored. Furthermore, correlations between the airway microbiome and adverse outcomes, such as bronchopulmonary dysplasia (BPD), have been established. Additional research in neonatal care is essential to understand the early colonization of infants’ airways and explore methods for its optimization. The critical opportunity to shape long-term health through microbiome-mediated effects likely lies within the neonatal period.

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Prenatal complications are associated with the postnatal airway host response and microbiota in intubated preterm infants

Cited by 6 publications

References 35 publications

Dysbiosis and Prematurity: Is There a Role for Probiotics?

Dysbiosis and Prematurity: Is There a Role for Probiotics?

The Microbiome and Preterm Birth: A Change in Paradigm with Profound Implications for Pathophysiologic Concepts and Novel Therapeutic Strategies

Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence

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