2022
DOI: 10.3390/nu14214643
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Abstract: Prenatal caffeine exposure (PCE) has been positively associated with elevated body mass index (BMI) in children. Why this association occurs is unclear, but it is possible that PCE alters the in utero development of brain structures associated with food preference, leading to more total sugar intake (TSI, grams) later in childhood. To test this hypothesis, we investigated if PCE (daily/weekly/<weekly vs. no exposure) and elevated BMI are associated with increased TSI, neural activation during large reward a… Show more

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Cited by 3 publications
(1 citation statement)
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References 65 publications
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“…Adenosine, through A 1 receptor, also modulates immature synapses in different regions such as hippocampus or developing cortex ( Jeong et al, 2003 ; Kerr et al, 2013 ; Burnstock and Dale, 2015 ). Therefore, dysfunction of purinergic signaling by caffeine overconsumption might impair brain development leading to deleterious effects, varying from mild cognitive impairment to severe neurological or psychiatric conditions ( Silva et al, 2013 ; Al-Basher et al, 2018 ; Serdar et al, 2019 ; Zhang et al, 2020 , 2022 ; Christensen et al, 2021 ; Agarwal et al, 2022 ).…”
Section: Energy Drinks and The Developing Brainmentioning
confidence: 99%
“…Adenosine, through A 1 receptor, also modulates immature synapses in different regions such as hippocampus or developing cortex ( Jeong et al, 2003 ; Kerr et al, 2013 ; Burnstock and Dale, 2015 ). Therefore, dysfunction of purinergic signaling by caffeine overconsumption might impair brain development leading to deleterious effects, varying from mild cognitive impairment to severe neurological or psychiatric conditions ( Silva et al, 2013 ; Al-Basher et al, 2018 ; Serdar et al, 2019 ; Zhang et al, 2020 , 2022 ; Christensen et al, 2021 ; Agarwal et al, 2022 ).…”
Section: Energy Drinks and The Developing Brainmentioning
confidence: 99%