Prenatal bisphenol A and S exposure and atopic disease phenotypes at age 6

Gaylord, Abigail; Barrett, Emily S.; Sathyanarayana, Sheela; Swan, Shanna H.; Nguyen, Ruby H.N.; Bush, Nicole R.; Carroll, Kecia N.; Day, Drew B; Trasande, Leonardo

doi:10.1016/j.envres.2023.115630

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…In a study involving various populations, the lowest levels of BPA were found in pregnant women from South Africa and the United States of America. The urinary concentrations of BPA during late pregnancy were found to be 1.16 and 0.73 ng/mL, respectively, whereas those of other bisphenols were similar to those observed in other population cohorts [ 65 , 66 ]. A study from South Korea reported the presence of BPA at a concentration of 0.53 ng/g in the placenta, indicating that it can be transferred from the mother to the fetus through the placental barrier [ 62 ].…”

Section: Contamination Status Of Bisphenolssupporting

confidence: 78%

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Wu,

Tian,

Zhu

et al. 2023

Toxics

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Reproductive disorders are considered a global health problem influenced by physiological, genetic, environmental, and lifestyle factors. The increased exposure to bisphenols, a chemical used in large quantities for the production of polycarbonate plastics, has raised concerns regarding health risks in humans, particularly their endocrine-disrupting effects on female reproductive health. To provide a basis for future research on environmental interference and reproductive health, we reviewed relevant studies on the exposure patterns and levels of bisphenols in environmental matrices and humans (including susceptible populations such as pregnant women and children). In addition, we focused on in vivo, in vitro, and epidemiological studies evaluating the effects of bisphenols on the female reproductive system (the uterus, ovaries, fallopian tubes, and vagina). The results indicate that bisphenols cause structural and functional damage to the female reproductive system by interfering with hormones; activating receptors; inducing oxidative stress, DNA damage, and carcinogenesis; and triggering epigenetic changes, with the damaging effects being intergenerational. Epidemiological studies support the association between bisphenols and diseases such as cancer of the female reproductive system, reproductive dysfunction, and miscarriage, which may negatively affect the establishment and maintenance of pregnancy. Altogether, this review provides a reference for assessing the adverse effects of bisphenols on female reproductive health.

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Section: Contamination Status Of Bisphenolssupporting

confidence: 78%

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Wu,

Tian,

Zhu

et al. 2023

Toxics

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“…Therefore, it is important to identify and analyze the environmental factors that affect human health and disease. The concept proposed for this purpose is the exposome, and its importance has been emphasized [1,2].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis

Kim,

Yu,

Choo

et al. 2024

IJMS

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Bisphenol is a chemical substance widely used in plastic products and food containers. In this study, we observed a relationship between DNA methylation and atopic dermatitis (AD) in the peripheral blood mononuclear cells (PBMCs) of pregnant women exposed to bisphenol A (BPA) and its alternatives, bisphenol S (BPS) and bisphenol F (BPF). DNA methylation is an epigenetic mechanism that regulates gene expression, which can be altered by environmental factors, and affects the onset and progression of diseases. We found that genes belonging to the JAK-STAT and PI3K-AKT signaling pathways were hypomethylated in the blood of pregnant women exposed to bisphenols. These genes play important roles in skin barrier function and immune responses, and may influence AD. Therefore, we suggest that not only BPA, but also BPS and BPF, which are used as alternatives, can have a negative impact on AD through epigenetic mechanisms.

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Recent advances of mass spectrometry-based analytical methods for endocrine disrupting chemicals in human matrices

Yue,

Zhou,

Fan

et al. 2024

TrAC Trends in Analytical Chemistry

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Prenatal bisphenol A and S exposure and atopic disease phenotypes at age 6

Cited by 3 publications

References 51 publications

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis

Recent advances of mass spectrometry-based analytical methods for endocrine disrupting chemicals in human matrices

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