Prenatal and Early Postnatal Exposure to Total Mercury and Methylmercury from Low Maternal Fish Consumption

Ursı́nyová, Monika; Mašánová, Vlasta; Uhnáková, Iveta; Murínová, Ľubica Palkovičová; Patayová, Henrieta; Rausova, Katarina; Trnovec, T.; Stencl, J; Gajdoš, Martin

doi:10.1007/s12011-018-1585-6

Cited by 15 publications

(7 citation statements)

References 47 publications

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“…This analysis of the training dataset found that the average blood MeHg/THg ratio was 0.75 (Table 2). This is similar to reported values: 0.69 to 0.85 from other analyses of NHANES data [28,30]; 0.63 from pregnant women in North Carolina [23]; 0.52 to 0.88 from populations in Europe [24,[31][32][33][34]; 0.86 from pregnant women in Suriname [35]; 0.72 to 0.93 from populations in Asia [22,29,36]; and 0.91 among newcomers to Canada [37]. Although the exact reason for the variation across populations is not known, it is possible this is related to differences in demographics or diet.…”

Section: Discussionsupporting

confidence: 90%

Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers

Wells

Kopylev

Nachman

et al. 2021

Biol Trace Elem Res

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Many studies evaluating methylmercury (MeHg) toxicity rely on whole blood total mercury (THg) measurements to estimate MeHg exposure. However, whole blood THg includes other forms of mercury (Hg), such as inorganic Hg, which have different exposure sources and toxicological effects than MeHg. Therefore, estimating the whole blood MeHg/THg ratio is critical to predicting MeHg exposure and, subsequently, efforts to establish an exposure–response relationship for use in risk assessment. A large, representative dataset (National Health and Nutrition Examination Survey (NHANES) 2011–2016) was used to determine the whole blood MeHg/THg ratio among (a) self-reported fish and shellfish consumers, ≥ 15 years of age (the “full adult” population (N = 5268 training dataset; N = 2336 test dataset)) and (b) female fish and shellfish consumers, 15–44 years of age (the “women of reproductive age” population (N = 1285 training dataset; N = 560 test dataset)). Unadjusted and adjusted linear and spline models with direct measurements for both THg and MeHg were evaluated. The mean whole blood MeHg/THg ratio was 0.75 (95% confidence interval (CI): 0.74, 0.75). This ratio was significantly higher among those with higher THg concentrations. All models exhibited excellent fit (adjusted R2 from 0.957 to 0.982). Performance was slightly improved in spline versus linear models. For the full adult population and women of reproductive age, the unadjusted spline model predicted whole blood MeHg concentrations of 5.65 µg/L and 5.55 µg/L, respectively, when the THg concentration was 5.80 µg/L. These results suggest that whole blood THg is a good predictor of whole blood MeHg among fish and shellfish consumers.

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Section: Discussionsupporting

confidence: 90%

Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers

Wells

Kopylev

Nachman

et al. 2021

Biol Trace Elem Res

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“…Five observational studies were included (89,(97)(98)(99)(100) . One on Hg, which was rated good quality (100) , one on Hg and Pb, which was rated good quality (99) ,one on As, B and Li, rated as fair quality (97) , one on Pb and Cd, rated as fair quality (89) , and one on PCB, rated as poor quality (98) . The results are summarised in Table 4.…”

Section: Contaminantsmentioning

confidence: 99%

Evaluating the relationship between the nutrient intake of lactating women and their breast milk nutritional profile: a systematic review and narrative synthesis

Falize,

Savage,

Jeanes

et al. 2023

Br J Nutr

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Maternal diet influences breast milk nutritional profile; however, it is unclear which nutrients and contaminants are particularly responsive to short- and long-term changes in maternal intake, and the impact of specific exclusion diets, such as vegan or vegetarian. This study systematically reviewed the literature on the effects of maternal nutrient intake, including exclusion diets, on both the nutrient and contaminant content of breast milk. The electronic databases, PubMed, CENTRAL, Web of Science and CINALH were systematically searched until 4 June 2023, with additionally searches of reference lists (PROSPERO, CRD42020221577). The quality of the studies was examined using Cochrane Risk of Bias tool and Newcastle–Ottawa scale. Eighty-eight studies (n 6577) met the search criteria. Due to high heterogeneity, meta-analysis was not possible. There was strong evidence of response to maternal intakes for DHA and EPA, vitamins A, E and K, iodine and Se in breast milk composition, some evidence of response for α-linolenic acid, B vitamins, vitamin C and D, ovalbumin, tyrosine and contaminants, and insufficient evidence to identify the effects arachidonic acid, Cu, Fe, Zn and choline. The paucity of evidence and high heterogeneity among studies reflects the need for more high-quality trials. However, this review identified the importance of maternal intake in the nutritional content of breast milk for a wide range of nutrients and supports the recommendation for supplementation of DHA and vitamin B12 for those on restrictive diets.

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“…5 Meanwhile, MeHg is lipophilic and can readily cross the placenta and accumulate in the fetus, resulting in higher levels of cord blood than maternal blood. 6 MeHg also poses a risk to infants when excreted through breast milk, but the risk is lower than in the embryo because the transport of MeHg is restricted. 7 MeHg is the most notable Hg compound because of its role in Minamata disease.…”

Section: Introductionmentioning

confidence: 99%

“…The brain has a high affinity for MeHg, and concentrations can be 3–6 times greater than those observed in blood . Meanwhile, MeHg is lipophilic and can readily cross the placenta and accumulate in the fetus, resulting in higher levels of cord blood than maternal blood . MeHg also poses a risk to infants when excreted through breast milk, but the risk is lower than in the embryo because the transport of MeHg is restricted …”

Section: Introductionmentioning

confidence: 99%

Advances on the Influence of Methylmercury Exposure during Neurodevelopment

Pan

Wei

et al. 2022

Chem. Res. Toxicol.

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Mercury (Hg) is a toxic heavy-metal element, which can be enriched in fauna and flora and transformed into methylmercury (MeHg). MeHg is a widely distributed environmental pollutant that may be harmful to fish-eating populations through enrichment of aquatic food chains. The central nervous system is a primary target of MeHg. Embryos and infants are more sensitive to MeHg, and exposure to MeHg during gestational feeding can significantly impair the homeostasis of offspring, leading to long-term neurodevelopmental defects. At present, MeHg-induced neurodevelopmental toxicity has become a hotspot in the field of neurotoxicology, but its mechanisms are not fully understood. Some evidence point to oxidative damage, excitotoxicity, calcium ion imbalance, mitochondrial dysfunction, epigenetic changes, and other molecular mechanisms that play important roles in MeHg-induced neurodevelopmental toxicity. In this review, advances in the study of neurodevelopmental toxicity of MeHg exposure during pregnancy and the molecular mechanisms of related pathways are summarized, in order to provide more scientific basis for the study of neurodevelopmental toxicity of MeHg.

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Prenatal and Early Postnatal Exposure to Total Mercury and Methylmercury from Low Maternal Fish Consumption

Cited by 15 publications

References 47 publications

Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers

Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers

Evaluating the relationship between the nutrient intake of lactating women and their breast milk nutritional profile: a systematic review and narrative synthesis

Advances on the Influence of Methylmercury Exposure during Neurodevelopment

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