2009
DOI: 10.1111/j.1552-6569.2008.00319.x
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Abstract: This study demonstrates that patients on statins have higher recanalization rates when they undergo endovascular procedures for acute ischemic stroke.

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Cited by 19 publications
(15 citation statements)
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“…2,18 In a rat model of embolic stroke, statin-treated animals showed smaller residual clot size and smaller infarct volumes, indicating that statins may promote recanalization. 19 Also, in stroke patients undergoing endovascular procedures, statins were linked to better recanalization, 20 although this was not confirmed in a larger study. 5 Furthermore, pre-existing statin treatment has been associated with greater reperfusion after acute stroke.…”
Section: Discussionmentioning
confidence: 87%
“…2,18 In a rat model of embolic stroke, statin-treated animals showed smaller residual clot size and smaller infarct volumes, indicating that statins may promote recanalization. 19 Also, in stroke patients undergoing endovascular procedures, statins were linked to better recanalization, 20 although this was not confirmed in a larger study. 5 Furthermore, pre-existing statin treatment has been associated with greater reperfusion after acute stroke.…”
Section: Discussionmentioning
confidence: 87%
“…In models of ischemia-reperfusion, statins have protected multiple organ systems against reperfusion injury 12, 13 and have augmented cerebral blood flow (CBF) secondary to upregulation of endothelial nitric oxide synthase (eNOS) 14 , although such a CBF effect was not reproduced in humans with atherosclerotic carotid occlusion 15 . In other clinical studies, statin use was associated with greater recanalization in a cohort of ischemic stroke patients undergoing acute intervention 16 , and in aneurysmal subarachnoid hemorrhage, patients treated with statins were less likely to develop vasospasm 17 . In several studies, the neuroprotective effects have been independent of cholesterol lowering 10, 11 .…”
Section: Introductionmentioning
confidence: 76%
“…10,11 In one (which included 4 observational studies and 1,055 patients), statin use was not associated with favorable functional outcome, but was a univariate predictor for symptomatic intracranial hemorrhage (sICH) (no multivariable analysis was conducted). [12][13][14] In addition, there are limited data in patients treated with endovas-cular therapy: 1 study reported a positive effect of prior statin use on recanalization, 15 whereas another study reported no effect. 11 This is in accordance with previous small single-center IV studies that reported contradictory data.…”
mentioning
confidence: 99%