Premorbid Asocial Adjustment and Response to Phenothiazine Treatment Among Schizophrenic Inpatients

An Attempted Integration of Information Relevant to Schizophrenic Subtypes

“…Leff and Wing (1971) suggest it is for those patients in the midprognostic range that maintenance medication has a decisive effect; poor prognosis patients in their studies tend to do poorly and good prognosis patients tend to do well regardless of medication status. Klein and Rosen (1973) reinforce this finding for poor prognosis schizophrenia but find drugs most efficacious in good prognosis patients.…”

Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement

“…These findings may be related to earlier onset of the illness in such individuals, and suggest that an early onset heralds a drug resistant form of the illness. Alternatively, the findings could be used in support of the suggested association between asociality and unsatisfactory response (Klein & Rosen, 1973). Indeed, the non-responders were less likely to have cohabited with a sexual partner than the responders.…”

Drug-related and illness-related factors in the outcome of chlorpromazine treatment: testing a model

“…There is, after all, good evidence that 336 T. Kolakowska, M. G. Celder and M. W. Orr schizophrenics who improve with treatment differ in several ways from those who do not (e.g. Harrow et al 1969;Klein & Rosen, 1973;Mandelbrote & Trick, 1970). However, these clinical differences do not predict outcome for the individual patient (May et al 1976); nor did any of the large number of clinical variables which we examined distinguish between groups of patients who improved and the rest.…”