trials. We conclude that electrodermal testing cannot diagnose allergy to common aeroallergens such as cat dander and house dust mite-allergens that have a strong association with atopic respiratory disorders such as asthma, rhinitis, eczema, and conjunctivitis.We thank Jackie Burnham for her help in preparing the manuscript, all the volunteers and the operators who gave up their time so willingly, and the doctors and practice manager at Hythe Medical Centre who made space and time available to us.Contributors: GTL, JNK, and STH conceived the study, developed the protocol, and obtained funding. JB was the trial manager. JG was responsible for the statistical design and randomisation, and PP for the analysis. All authors were jointly involved in writing the paper. STH will act as guarantor.Funding: The study was supported by funding from Vega Grieshaber, the Asthma Allergy and Inflammation Research Trust, and the Foundation for Integrated Medicine.Competing interests: GTL and JNK formerly had interests in a company involved in the distribution of Vega Grieshaber products and both have received fees for speaking at a seminar on the Vegatest. Results Improvement in the main variable was greater in the active group compared with placebo group (P < 0.001). Analysis of the secondary variables showed significant (P < 0.001) superiority of active treatment in each of the three global impression items. Responder rates were 52% and 24% for active and placebo, respectively. Seven women reported mild adverse events (four active; three placebo), none of which caused discontinuation of treatment. Conclusions Dry extract of agnus castus fruit is an effective and well tolerated treatment for the relief of symptoms of the premenstrual syndrome.