Premedication with intravenous low-dose ketamine suppresses fentanyl-induced cough

Yeh, Chun Chang; Wu, Ching Tang; Huh, Billy K.; Lee, Meei Shyuan; Lin, Shinn Long; Sheen, Michael J.; Wong, Chih Shung

doi:10.1016/j.jclinane.2006.05.021

Cited by 65 publications

(60 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, induced cough in humans is preceded by an initial urge to cough (Davenport et al, 2007;Dicpinigaitis et al, 2012), an observation that is likely the clinical manifestation of the physiologic evidence that cough initiation requires sustained, high-frequency vagal afferent nerve activation in animals (Canning, 2009;Canning and Mori, 2011). Consistent with the involvement of NMDA receptors in cough, both ketamine and dextromethorphan have been reported to suppress cough in patients (Yeh et al, 2007;Faruqi et al, 2014). Moreover, in preclinical studies, dextromethorphan and other NMDA receptor/channel blockers prevent evoked coughing in dogs, cats, rabbits, guinea pigs, and rats (Kamei et al, 1989;Dicpinigaitis et al, 2014a;reviewed in Canning, 2009, andCanning andMori, 2011).…”

Section: Discussionmentioning

confidence: 86%

Effect of Memantine on Cough Reflex Sensitivity: Translational Studies in Guinea Pigs and Humans

Dicpinigaitis

Canning

Garner

et al. 2014

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Cough is the most common complaint for which outpatients in the United States seek medical attention, and yet available therapeutic options for cough lack proven efficacy and are further limited by safety and abuse liabilities. Thus, safe and effective cough suppressants are needed. Recent preclinical studies described the antitussive effects of memantine, an N-methyl-D-aspartate receptor channel blocker used in the treatment of Alzheimer's disease. The goals of the present study were to compare the antitussive effects of memantine, dextromethorphan, and codeine in guinea pigs; to relate the dosedependent actions of memantine in these studies to peak plasma concentrations achieved following oral administration; and to provide the first ever evaluation of the antitussive effect of memantine in humans. In guinea pigs, memantine and codeine were comparable in efficacy and potency but both were superior to dextromethorphan in the citric acid cough challenge model. The pharmacokinetic analyses suggest that memantine was active in guinea pigs at micromolar plasma concentrations. Subsequently, 14 healthy volunteers as well as 14 otherwise healthy adults with acute viral upper respiratory tract infection (URI) underwent capsaicin cough challenges 6 hours after ingestion of 20 mg memantine and matched placebo in a randomized, double-blind, crossover fashion. In healthy volunteers, memantine significantly inhibited cough reflex sensitivity (P 5 0.034). In subjects with URI, responsiveness to capsaicin was markedly increased, and in these patients, the inhibition of cough reflex sensitivity by memantine relative to placebo did not reach statistical significance (P 5 0.088). These data support further research to investigate the potential of memantine as a clinically useful antitussive.

show abstract

Section: Discussionmentioning

confidence: 86%

Effect of Memantine on Cough Reflex Sensitivity: Translational Studies in Guinea Pigs and Humans

Dicpinigaitis

Canning

Garner

et al. 2014

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…As a previous study had reported that the incidence of cough following fentanyl 1.5 lg.kg )1 was 21.6% [6], we decided to give fentanyl 25 lg as the pre-emptive dose (0.3-0.5 lg.kg…”

Section: Methodsmentioning

confidence: 99%

“…Previous reports have demonstrated that fentanylinduced cough can be reduced with pretreatment of certain drugs [2][3][4][5][6][7]. This may not only be more costly, it may also be unnecessary.…”

mentioning

confidence: 99%

The effect of pre‐emptive use of minimal dose fentanyl on fentanyl‐induced coughing

Hung¹,

Chen

Lin

et al. 2009

Anaesthesia

View full text Add to dashboard Cite

SummaryWe performed a randomised, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous fentanyl (25 lg) on the incidence of cough caused by a larger bolus of intravenous fentanyl. Six hundred patients were randomly assigned to one of three groups to receive either 0.5 ml saline 0.9% 1 min before administration of fentanyl 150 lg (3 ml), or pre-emptive fentanyl 25 lg (0.5 ml) 1 min before administration of fentanyl 125 lg or 150 lg. The incidence of fentanyl-induced cough was significantly lower in both pre-emptive groups (7 (3.5%) for 125 lg fentanyl and 15 (7.5%) for 150 lg fentanyl) than in the saline group (37 (18.5%); p = 0.001). We conclude that pre-emptive use of fentanyl 25 lg, administered 1 min before bolus injection of fentanyl (125 or 150 lg), can effectively suppress fentanyl-induced cough.

show abstract

“…Fentanyl-induced cough could also be the result of a mechanical or chemical stimulation of sensory receptors within the respiratory tract; the afferent impulses from these receptors may activate a putative brainstem cough center [7]. Drugs such as ketamine, terbutaline, clonidine, dexamethasone, and lidocaine as well as performing some maneuvers such as a forced expiration against open glottis, dilution of fentanyl to 10 μg/ ml, and prolonged injection time have all been evaluated in reducing this fentanyl induced cough [8][9][10][11][12][13]. Dextromethorphan is an antitussive drug that is used for suppression of cough caused by minor throat and tracheo-bronchial irritation, especially after inhalation of any irritants.…”

Section: Introductionmentioning

confidence: 99%

Suppressing Effect of Dextromethorphan or Clonidine on Fentanyl- Induced Coughing: A Double- Blind, Prospective, Randomized Placebo- Controlled Study

Marashi¹

2013

J Pulm Respir Med

View full text Add to dashboard Cite

show abstract

Premedication with intravenous low-dose ketamine suppresses fentanyl-induced cough

Cited by 65 publications

References 25 publications

Effect of Memantine on Cough Reflex Sensitivity: Translational Studies in Guinea Pigs and Humans

Effect of Memantine on Cough Reflex Sensitivity: Translational Studies in Guinea Pigs and Humans

The effect of pre‐emptive use of minimal dose fentanyl on fentanyl‐induced coughing

Suppressing Effect of Dextromethorphan or Clonidine on Fentanyl- Induced Coughing: A Double- Blind, Prospective, Randomized Placebo- Controlled Study

Contact Info

Product

Resources

About