Premature luteinization defined as progesterone estradiol ratio >1 on hCG administration day seems to adversely affect clinical outcome in long gonadotropin‐releasing hormone agonist cycles

Abstract

Premature luteinization, defined as P/E2 > 1 on human chorionic gonadotropin administration day, in long gonadotropin-releasing hormone agonist cycles seems to adversely affect clinical outcome.

Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval

“…In this study, FSH levels during ovarian hyperstimulation were not higher in Group 3 patients. Their elevated P 4 /E 2 (O1) still suggests an increased risk for premature luteinization (Ozcakir et al 2004).…”

“…The P 4 /E 2 was significantly higher in Group 3, while there was no significant difference between Groups 1 and 2. An elevated P 4 /E 2 is a well known marker of premature luteinization (Ozcakir et al 2004) and, therefore, suggested that older patients might be at higher risk for premature luteinization than the other two groups.…”

Progesterone level and progesterone/estradiol ratio on the day of hCG administration: detrimental cutoff levels and new treatment strategy

“…However, despite pituitary down-regulation, several researchers have described a phenomenon reported as premature luteinization (PL) (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). It has been described as a subtle premature increase in serum progesterone (P) levels on the day of hCG administration above a threshold level, which varied among different studies and was usually arbitrarily defined (3)(4)(5)(6)(7).…”

The effect of hyperstimulation on transforming growth factor β1 and β2 in the rat uterus: possible consequences for embryo implantation

“…Another approach for explaining the influence of the P:E 2 ratio on the absence of implantation sites in hyperstimulated animals could arise from recent work by Ozcakir et al (2004). They observed the outcome of premature luteinization which was defined as a progesteroneoestradiol ratio > 1 on the day of hCG administration.…”

“…Group A consisted of patients whose P:E 2 ratio was 1 while Group B comprised patients with premature luteinization whose P:E 2 ratio was >1. The primary outcome measure in this study by Ozcakir et al (2004) was oocyte quality, fertilization rate and clinical pregnancy rate, which were all adversely affected by premature luteinization defined as P:E 2 ratio >1. Indeed, the pregnancy outcome of the present study could have been affected by the dominance of progesterone (P:E 2 >1) which was observed at 5.5 and 6.5 days of pregnancy in the hyperstimulated animal.…”