Premature Ejaculation and Serum Leptin Level: A Diagnostic Case-Control Study

Abstract

Introduction Premature ejaculation (PE) is regarded as the most common male sexual disorder. To date, there is no accurate and objective diagnostic test for PE. Aim To determine the diagnostic value of serum leptin level for PE. Methods In a case-control design, the serum leptin level of 46 PE patients referred to our outpatient clinic were determined and compared with 44 control patients referred to the same clinic with the complaint of nephrolithiasis. PE was defined based on the Diagnostic and Statistical Manual of Mental Disorders IV criteria and an intravaginal ejaculatory latency time of less than a minute. Main Outcome Measures Serum leptin level and presence of PE. Results The PE patients had significantly higher serum leptin levels (8.3 ± 3 ng/mL) than the controls (3.3 ± 1 ng/mL) (P < 0.001). Sensitivity and specificity for the test as a predictive diagnostic tool for PE were 80.4% and 97.7%, respectively, at the cutoff value of 6.3 ng/mL. Conclusion According to our results, leptin level in patients with PE was significantly higher than in the control subjects. More studies are necessary to determine the value of serum leptin as a diagnostic tool for PE.

Study of the Role of Body Mass Index and Serum Leptin as Potential Risk Factors in Patients with Lifelong Premature Ejaculation

“…This finding can be seen in line with Reas et al (2007) who demonstrated that accelerated weight gain occurs mainly during younger adulthood as it represents a critical time period due to ensuant lifestyle changes involving energy expenditure, dietary intake and they inaccurately assume their weight falls into a normal weight range [26] . Finally, the current results affirmed [17,27] .…”

“…To the best of our knowledge, this study was the first report to demonstrate a significant relation between BMI and serum leptin in the cases as Nikoobakht and his colleagues as they failed to reveal an association between BMI and serum leptin in their studied cases [17] . Recently, Ventus and his colleague (2016) assumed a potential association between BMI and PE [28] .…”

“…Eventually, Atmaca and his colleagues (2002) and Nikoobakht and his colleagues (2008) reported that serum leptin levels in the patients with PE were significantly higher than that in healthy controls [16][17] . Till now, there is no more information about the risk factors in lifelong premature ejaculation other than genetic hypothesis that was firstly postulated by Waldinger et al (1998) [18] .…”

Nonresponders to Daily Paroxetine and Another SSRI in Men With Lifelong Premature Ejaculation: A Pharmacokinetic Dose-Escalation Study for a Rare Phenomenon

“…Notably, in contrast to their first study, the second study of Atmaca et al [7] reported a high serum leptin concentration in their control males (24.2±3.8 ng/mL). This finding of Atmaca et al [7] also contrasts the findings of Nikoobakht et al [10], who in 46 Iranian men with PE found a normal but higher baseline serum leptin level (8.3±3 ng/mL) than in a control group of 44 men with nephrolithiasis (3.3±1 ng/mL).…”

“…The aim of the current study was to investigate the role of various pharmacokinetic factors (e.g., paroxetine dosage, serum paroxetine level, Cyp2D6 activity) and serum leptin, gonadotrophin, and prolactin levels, all of which had previously been suggested to be related to PE and SSRI-induced ejaculation delay [7,9,10]. In addition, on the basis of the hypothesis of Waldinger et al [11] that the IELT in men with lifelong PE is related to 5-HT 1A and/or 5-HT 2C receptor functioning, we investigated the role of 5-HT 1A receptor gene C(-1019)G polymorphism.…”