Preliminary Study on the Relationship of BRAF Mutations with the Outcome of the First 131I Radiotherapy and Malignant Biological Characteristics in Papillary Thyroid Carcinoma

Abstract

To investigate the relationship of BRAF mutation with the outcome of the first postoperative 131 I treatment and malignant biological characteristics in papillary thyroid carcinoma (PTC). Methods: Thirty-three patients with PTC who underwent their first 131 I treatment after total thyroidectomy were enrolled in this study. BRAF mutation in postoperative tumor tissue and circulating tumor DNA (ctDNA) in peripheral blood at the time of 131 I treatment were detected. According to the status of BRAF mutation, all patients were divided into 2 groups in each category of tumor tissues and ctDNA, respectively: 1) BRAF mutation, 2) BRAF wild-type. The Fisher's exact test was performed to analyze the relationship of BRAF mutation in either tumor tissue or ctDNA with the outcome of the first 131 I treatment and malignant characteristics of PTC. Results: BRAF mutation was detected in tumor tissues in 25 patients (25/33,75.8%), and all the patients had single mutation site. In ctDNA, BRAF mutation was detected in 5 patients (5/33, 15.2%), and all the patients had single mutation site. In both tumor tissues and ctDNA, BRAF mutation showed no relationship with the outcome of first 131 I treatment and the malignant biological characteristics (P>0.05). Conclusion:The value of BRAF mutation alone might be limited in predicting therapeutic outcome of the first 131 I treatment in PTC. No definitive relevance was found between BRAF mutation and malignant biological features in PTC.

Multifunctional Phase-Transition Nanoparticles for Effective Targeted Sonodynamic-Gene Therapy Against Thyroid Papillary Carcinoma

“…The radiation generated by reaching a higher effective dose will cause damage to the body and the possibility of causing dedifferentiation of the lesion. 33–35 Although thermal ablation has the advantages of less surgical trauma and less influence on thyroid function. However, in recent years, the discussion on thermal ablation therapy of PTC has not stopped.…”