Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh).

Abstract

Abstract. Myrrh (from the stem of the Commiphora molmol tree) is an oleo gum resin that may prove efficacious for the treatment of fascioliasis. We studied 7 patients who were passing Fasciola eggs in their stools and treated them with myrrh. The drug (a formulation consisting of 8 parts of resin and 3.5 parts of volatile oils, all extracted from myrrh) was given in a dose of 12 mg/kg per day for 6 consecutive days in the morning on an empty stomach. Patients were followed for 3 months. The therapy proved to be effective, with pronounced improvement of the general condition and amelioration of all symptoms and signs. A dramatic drop in the egg count was detected at the end of treatment. Eggs were no longer detectable in the feces 3 weeks after treatment and after a follow-up period of 3 months. High eosinophilic counts, elevated liver enzymes, and Fasciola antibody titers returned to nearly normal. No signs of toxicity or adverse effects were observed. We conclude that the formulation of myrrh is safe, well tolerated, and effective for treating fascioliasis.

Effects of Mirazid® and myrrh volatile oil on adult Fasciola gigantica under laboratory conditions

“…It contains 7%-17% volatile oil, 25%-40% resin, 57%-61% gum, and 3%-4% impurities [12] . The gum contains polysaccharides and proteins, while the volatile oil is composed of steroids, sterols and terpenes.…”

Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

“…Both genera belong to the family Burseraceae, which is native to Northeast Africa and the Middle East. 1,2 Frankincense and myrrh have been used for medical purposes in China and India for thousands of years. 3 In traditional Chinese medicine, frankincense and myrrh have synergistic effects when used in combination (generally in a 1:1 ratio), and the book Compendium of Materia Medica introduced the therapeutic characteristics of the combination of frankincense and myrrh during the Ming Dynasty.…”

Evaluation of Myrrh (Commiphora Molmol) Essential Oil Activity Against Some Storage Fungi

“…Myrrh was well-known and used extensively during Bibilical times, it was used in foods and drinks as a flavoring agent, in perfumes and other cosmetics as a fragrance, in incense as a part of religious ceremonies and in embalming as a preservative (2). Medicinally, Myrrh was taken orally to treat arthritis, digestive complaints, schistosomiasis and respiratory infection; it was also taken to treat leprosy and syphilis (3,4). Topically, Myrrh was also applied to bacterial and fungal skin infections (1,5).…”