Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors

O’Connor, James P.B.; Naish, Josephine H.; Parker, Geoffrey; Waterton, John C.; Watson, Yvonne; Jayson, Gordon C; Buonaccorsi, Giovanni A.; Cheung, Susan; Buckley, David L.; McGrath, Deirdre M.; West, Catharine M L; Davidson, Susan E; Roberts, Caleb; Mills, Samantha J.; Mitchell, Claire L.; Hope, Lynn; Ton, Nhuan C; Jackson, Alan

doi:10.1016/j.ijrobp.2008.12.040

Cited by 105 publications

(122 citation statements)

References 36 publications

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“…Accompanied measurements such as cerebral blood volume/flow during CO 2 /air inhalation or R1 relaxation rate during carbogen inhalation [48] may complement the assessment of R2*. In this work we favoured the investigation of two different inhalation gases.…”

Section: Discussionmentioning

confidence: 99%

Analysing the response in R2* relaxation rate of intracranial tumours to hyperoxic and hypercapnic respiratory challenges: initial results

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Analysing the response in R2* relaxation rate of intracranial tumours to hyperoxic and hypercapnic respiratory challenges: initial results

et al. 2010

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“…Finally, in addition to examining T2*, the shortening of the tissue water T1 value during hyperoxic gas breathing has been proposed to measure oxygenation. 59,60 A combination of ⌬R2* and ⌬R1 measurements may yield new insights into brain tissue oxygenation.…”

mentioning

confidence: 99%

Imaging Brain Oxygenation with MRI Using Blood Oxygenation Approaches: Methods, Validation, and Clinical Applications

Christen

Bolar

Zaharchuk

2012

AJNR Am J Neuroradiol

101

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SUMMARY:In many pathophysiologic situations, including brain neoplasms, neurodegenerative disease, and chronic and acute ischemia, an imbalance exists between oxygen tissue consumption and delivery. Furthermore, oxygenation changes following a stress challenge, such as with carbogen gas or acetazolamide, can yield information about cerebrovascular reactivity. The unique sensitivity of the BOLD effect to the presence of deoxyhemoglobin has led to its widespread use in the field of cognitive neurosciences. However, the high spatial and temporal resolution afforded by BOLD imaging does not need to be limited to the study of healthy brains. While the complex relationship between the MR imaging signal and tissue oxygenation hinders a direct approach, many different methods have been developed during the past decade to obtain specific oxygenation measurements. These include qBOLD, phase-and susceptibility-based imaging, and intravascular T2-based approaches. The aim of this review is to give an overview of the theoretic basis of these methods as well as their application to measure oxygenation in both healthy subjects and those with disease. ABBREVIATIONS:BOLD ϭ blood oxygen level-dependent; CMRO 2 ϭ cerebral metabolic rate of oxygen consumption; OEF ϭ oxygen-extraction fraction; pO 2 ϭ

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“…No significant changes in R 2 * occur with oxygen alone. In patients with advanced cancer in the abdomen and pelvis an oxygen inspiration challenge showed significant increases in R1 in the majority of cases [178]. Comparison with regional perfusion data showed congruence in most areas of the tumour, but some areas of mismatch with high levels of perfusion were not associated with significant changes in oxygen concentration.…”

Section: Oxygen-enhanced Mrimentioning

confidence: 89%

Imaging hypoxia in gliomas

Mendichovszky¹,

Jackson²

2011

BJR

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Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors

Cited by 105 publications

References 36 publications

Analysing the response in R2* relaxation rate of intracranial tumours to hyperoxic and hypercapnic respiratory challenges: initial results

Analysing the response in R2* relaxation rate of intracranial tumours to hyperoxic and hypercapnic respiratory challenges: initial results

Imaging Brain Oxygenation with MRI Using Blood Oxygenation Approaches: Methods, Validation, and Clinical Applications

Imaging hypoxia in gliomas

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