2006
DOI: 10.1590/s1678-91992006000100007
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Preliminary studies with a neurotoxin obtained from Bungarus caeruleus venom

Abstract: The neurotoxin purified from the venom of Bungarus caeruleus causes a neuromuscular blockade on acetylcholine-induced muscle twitch response in isolated frog rectus abdominis muscle preparation. Neuromuscular blockade produced by d-tubocurarine on acetylcholine-induced muscle twitch response in an isolated frog rectus abdominis muscle preparation was reversed to normal muscle twitch response in presence of neostigmine. Whereas the purified neurotoxin produced an irreversible neuromuscular blockade in presence … Show more

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Cited by 5 publications
(3 citation statements)
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“…In Pakistan, no specific work is done on local species of Bungarus caeruleus for the determination of LD 50 . In our study the LD 50 value of its venom in mice model is 0.2828 μg/g which is contradictory to previous reports demonstrated Engelmann and Obst et al their obtained LD 50 value is 0.169 μg/g through I.V mode of injection [18] Other findings obtained by Mirajkar and More et al demonstrated that when crude venom administered intravenously cause lethality in mice with usual neurotoxic symptoms and resultant LD 50 value was 160 μg/kg or 0.16 μg/g [19]. According to geographical conditions and other factors, venom composition varies widely as demonstrated in values.…”
Section: Resultscontrasting
confidence: 59%
“…In Pakistan, no specific work is done on local species of Bungarus caeruleus for the determination of LD 50 . In our study the LD 50 value of its venom in mice model is 0.2828 μg/g which is contradictory to previous reports demonstrated Engelmann and Obst et al their obtained LD 50 value is 0.169 μg/g through I.V mode of injection [18] Other findings obtained by Mirajkar and More et al demonstrated that when crude venom administered intravenously cause lethality in mice with usual neurotoxic symptoms and resultant LD 50 value was 160 μg/kg or 0.16 μg/g [19]. According to geographical conditions and other factors, venom composition varies widely as demonstrated in values.…”
Section: Resultscontrasting
confidence: 59%
“…Its venom also contains a novel postsynaptic neurotoxin, termed κ-flavitoxin, which is a potent inhibitor of nicotinic transmission in autonomic ganglia (4,5). The venoms of several common Bungarus species have been well investigated (6)(7)(8). Little, however, is known about the enzymatic properties of the Bungarus flaviceps venom.…”
Section: Introductionmentioning
confidence: 99%
“…Forkrait (Bungaruscaeruleus) LD 50 calculated by Perveen et al 5 is 0.2828 μg/g for intravenous route. Engelmann and Obst et al 9 obtained LD 50 value is 0.169μg/g and Mirajkar & More et al 10 reported LD 50 of 0.16 μg/g. Australian Venom and Toxin database depicts the LD 50 value 0.169μg/g for Krait.…”
mentioning
confidence: 97%