Preliminary report of improved sleep quality in patients with dry eye disease after initiation of topical therapy

Ayaki, Masahiko; Toda, Ikuko; Tachi, Naoko; Negishi, Kazuno; Tsubota, Kazuo

doi:10.2147/ndt.s94648

Cited by 28 publications

(28 citation statements)

References 27 publications

(32 reference statements)

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“…One study evaluated the effect of topical medication on the sleep of patients with DED and suggested that a consultation-liaison psychiatry service (i.e., collaboration with psychiatrists and other medical specialists may be helpful for patients with DED and potential psychiatric problems). 102 The study evaluated sleep quality in 71 patients with DED using a questionnairebased survey before and after topical treatment for DED. The effectiveness of sleep and ophthalmic services in assisting with sleep problems in patients with eye disease was assessed using the PSQI and HADS.…”

Section: Ophthalmic Measures Followed By a Consultation-liaison Psychmentioning

confidence: 99%

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Ayaki

Ohta

Kawashima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Sleep is an essential life habit and closely associated with lifespan, diabetes, hypertension, and mental health. Sleep disorders are a prominent, but overlooked problem in patients with dry eye disease (DED), characterized by a poor sleep index, short sleep duration, long sleep latency, and poor subjective sleep. DED and sleep disorders are more prevalent in women than men. Moreover, sleep quality in DED is worse than in other eye diseases, including glaucoma, retinal diseases, cataract, and allergic and chronic conjunctivitis. METHODS. We reviewed the literature for studies investigating sleep and health, eyes and sleep, and DED and sleep, in terms of systemic and eye health, especially in women. RESULTS. Two studies reported that approximately half of patients with DED suffer from poor sleep. The severity of mood disorders, including anxiety and depression, is correlated strongly with sleep disorders in DED, and the symptoms and signs of DED, especially pain, also are correlated with sleep quality. Sleep disorders are documented in primary Sjögren's syndrome and an association with sleep apnea and depression is suggested. Primary Sjögren's syndrome includes arthritis and other rheumatic disease causing pain and fatigue; however, how sicca contributes to sleep disorders is not known. CONCLUSIONS. Possible explanations for sleep disorders in DED may be depression, pain, and eye exposure at night. Reciprocal effects may be expected and consultation-liaison psychiatry is recommended for the management of sleep disorders in DED. Topical medication and lid heating also may be advantageous for sleep quality in DED.

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Section: Ophthalmic Measures Followed By a Consultation-liaison Psychmentioning

confidence: 99%

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Ayaki

Ohta

Kawashima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Symptoms rarely completely disappear, while their reduction positively affects patients' quality of life and improves sleep and mood disorders 4 5…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous periorbital electrical stimulation in the treatment of dry eye

et al. 2016

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“…Ayaki et al40 revealed that topical treatment with eye drops significantly improved PSQI in patients with DED, and the improvement was greater in newly diagnosed DED compared to established DED, suggesting that DED may also influence sleep disorder and that early treatment of DED can also improve sleep quality. They also reported that combination of sleep services and topical treatment with eye drops could successfully treat patients with sleep disorders overlapped with DED 40…”

Section: Association With Psychiatric Problemsmentioning

confidence: 99%

“…Treatment of accompanying psychiatric or neurological problems can be helpful in alleviating dry eye symptoms. Considering the reciprocal influence between DED and psychiatric disorders, comprehensive management of both conditions would be more beneficial 40,81…”

Section: Managementmentioning

confidence: 99%

Association of dry eye disease with psychiatric or neurological disorders in elderly patients

Han

Yang²,

Hyon³

et al. 2017

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Dry eye disease (DED) is a common disease that can impair quality of life significantly. Its prevalence increases with advancing age, and the economic burden of the disease on both a patient and the society is increasing with elongation of life expectancy. The diagnosis and treatment of DED are often difficult due to the discordance between symptoms and signs of the disease. Recent studies have suggested the role of neurological or psychological factors in the development of dry eye symptoms and discrepancy of the symptoms and signs, particularly in elderly patients. In this review, the authors discuss the association of DED with various psychiatric and neurological disorders. In addition to psychiatric conditions, including depression, anxiety, stress, posttraumatic stress disorder and sleep disorders, medications for the psychiatric disorders have association with DED. Neurological disorders, such as neuropathic pain, chronic pain syndrome, peripheral neuropathy and several central nervous system disorders, are related to DED. Treatment of DED, combined with psychiatric or neurological disorders, is also discussed. Attention should be paid to the DED patients with discordant symptoms and signs, and unsatisfactory response to conventional treatment for associated psychiatric or neurological disorders, as well as an integrated treatment approach, could be helpful for these patients.

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Preliminary report of improved sleep quality in patients with dry eye disease after initiation of topical therapy

Cited by 28 publications

References 27 publications

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Transcutaneous periorbital electrical stimulation in the treatment of dry eye

Association of dry eye disease with psychiatric or neurological disorders in elderly patients

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