J. Neurosci. Res. volume 85, issue 14, P3160-3170 2007 DOI: 10.1002/jnr.21384 View full text
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WenJing Jiang, BinFeng Du, ZhaoFu Chi, Lin Ma, ShengJun Wang, XuHua Zhang, Wei Wu, XiaoHua Wang, GuangRun Xu, ChunNi Guo

Abstract: Approximately 20-30% of patients with epilepsy continue to have seizures despite carefully monitored treatment with antiepileptic drugs. The mechanisms that underlie why some patients are responsive and others prove resistant to antiepileptic drugs are poorly understood. Increasing evidence supports a role for altered mitochondrial function in the pathogenesis of epilepsy. To gain greater molecular insight in the pathogenesis of intractable epilepsy, we undertook a global analysis of protein expressions in a p…

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