2014
DOI: 10.18632/aging.100651
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Abstract: Aging, a time-dependent functional decline of biological processes, is the primary risk factor in developing diseases such as cancer, cardiovascular or degenerative diseases. There is a real need to understand the human aging process in order to increase the length of disease-free life, also known as “health span”. Accumulation of progerin and prelamin A are the hallmark of a group of premature aging diseases but have also been found during normal cellular aging strongly suggesting similar mechanisms between h… Show more

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Cited by 44 publications
(57 citation statements)
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References 55 publications
(74 reference statements)
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“…Analysis of the transcriptome and micro RNAs of breast resident AD-MSCs revealed that migrating cells displayed similar profiles to those of resident AD-MSCs in this condition, suggesting a role of resident AD-MSCs in breast cancer development (Senst et al, 2013). Human BM-MSCs transcriptomics was also used to investigate the accumulation of progerin and prelamin A in premature aging diseases (Infante et al, 2014). As increasing numbers of transcriptome datasets became available, computation data mining has been applied to investigate MSC gene expression profiles in elderly patients with osteoporosis (Zhou et al, 2015).…”
Section: Exploring Disease Associationmentioning
confidence: 95%
See 1 more Smart Citation
“…Analysis of the transcriptome and micro RNAs of breast resident AD-MSCs revealed that migrating cells displayed similar profiles to those of resident AD-MSCs in this condition, suggesting a role of resident AD-MSCs in breast cancer development (Senst et al, 2013). Human BM-MSCs transcriptomics was also used to investigate the accumulation of progerin and prelamin A in premature aging diseases (Infante et al, 2014). As increasing numbers of transcriptome datasets became available, computation data mining has been applied to investigate MSC gene expression profiles in elderly patients with osteoporosis (Zhou et al, 2015).…”
Section: Exploring Disease Associationmentioning
confidence: 95%
“…In consideration of clinical safety using MSCs, a culture medium that is serum-free Human BM-MSCs may undergo spontaneous changes during long-term culture and immunosuppressive and anti-inflammatory properties may be lost (Infante et al, 2014).…”
Section: Health and Safety Aspectsmentioning
confidence: 99%
“…Of note, several factors, such as POU2F1, DLX4, BCL11A, KLF5, GATA3, AIRE and FLH2 are involved in governing stem cell functions (self-renewal, cell fate specification, cell survival under stress). [57][58][59][60][61][62][63] Only a few miRNAs were found to be putative upstream regulators of proteins present in MSC and Muse cell secretomes (Table 3). In detail, mir-122 and mir-133 appear related to functions ascribed to secretomes of MSCs and Muse cells, such as remodeling of extracellular matrix, metabolic processes and stemness control.…”
Section: Muse Cells Secrete Factors That May Play a Role In Stem Cellmentioning
confidence: 99%
“…10 The farnesylation state avoids formation of mixed networks of A-and B-type lamins and influences their interaction with NE constituents, chromatin-associated proteins, and transcription factors. [10][11][12][13][14] Moreover, lamins undergo phosphorylation and SUMOylation, further regulating their own intermolecular interactions. The best-recognized binding partner of lamin A/C at the NE is emerin, while the best-known partner of B-type lamins is the lamin B receptor (LBR).…”
Section: The Nuclear Envelopementioning
confidence: 99%