Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss

Ozawa, Nobuaki; Maruyama, Tetsuo; Nagashima, Takashi; Ono, Masanori; Arase, Toru; Ishimoto, Hitoshi; Yoshimura, Yasunori

doi:10.1016/j.fertnstert.2007.09.051

Cited by 39 publications

(51 citation statements)

References 11 publications

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“…The presence of chromosome abnormalities in a parental carrier is one of the most reliable etiologies, and balanced chromosomal rearrangements have been observed in couples with RPL (De Braekeleeret and Dao, 1990). The effectiveness of pre-implantation genetic diagnosis (PGD) remains elusive (Ozawa et al, 2008). Sugiura-Ogasawara et al (2004) reported that PGD for RPL couples is not necessary.…”

Section: Introductionmentioning

confidence: 99%

Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of chromosome abnormalities or polymorphisms

Dong¹,

Li²,

Wang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The subsequent reproductive outcomes in couples with a history of recurrent pregnancy loss (RPL) associated with chromosome abnormalities or polymorphisms are generally not reported in China. Many RPL carrier couples have decided not to have children. The present study recorded the subsequent delivery, miscarriage, and unpregnancy outcomes of 113 RPL carrier couples and 226 non-carrier couples, and compared differences in reproductive outcomes between couples with different types of chromosome abnormalities or polymorphisms and chromosome normal couples. Our results showed that couples with RPL associated with parental chromosome abnormalities or polymorphisms did not have significantly lower live birth rates than non-carrier couples in China. These results suggest the current guidance given to Chinese RPL couples.

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Section: Introductionmentioning

confidence: 99%

Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of chromosome abnormalities or polymorphisms

Dong¹,

Li²,

Wang³

et al. 2014

Genet. Mol. Res.

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“…Interestingly, the adjusted odds ratio of subsequent miscarriage in the couples with inv(9) in either partner was significantly higher in a recent study, although inv (9) generally is thought to have no adverse effect on reproduction as a normal variant [28].…”

Section: Genetic Abnormalities Embryonic Chromosomal Abnormalitiesmentioning

confidence: 72%

“…A chromosomal abnormality in one partner is found in 3% [17], 5% [28] to 21% of RM couples [8,30,31]. The abnormality is about twice as likely to occur in the mother as well as father.…”

Section: Genetic Abnormalities Embryonic Chromosomal Abnormalitiesmentioning

confidence: 98%

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Recurrent Miscarriage: A Review

Barrenetxea¹

2017

RMGO

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pregnancy events [2]. Clinical miscarriages may be subdivided into early clinical pregnancy losses (before gestational week 12) and late clinical pregnancy losses (gestational weeks 12 to 21). The term miscarriage is preferred rather than abortion both by patients and physicians, although "spontaneous abortion" is still used in scientific literature [3,4].For more than 30 years, controversy has existed on the number of miscarriages required to define RM and when diagnostic testing is warranted [5] EpidemiologyEarly pregnancy loss is perhaps the most common obstetric complication, occurring in over two-thirds of human conceptions. Approximately 15 -20% of all clinically recognized pregnancies will end in a miscarriage [4,9,10]. However, prospective cohort studies using sensitive and specific daily urinary hCG assays in women trying to conceive have demonstrated that only around one-third of conceptions progress to a live birth. Most of the losses occur before the clinical recognition of pregnancy as implantation failures. An estimated 30% of human conceptions are lost prior to implantation and a further 30% following implantation but before the missed menstrual period, that is in the third or fourth week of gestation. These are often termed preclinical losses [11].The risk of sporadic miscarriage between 6 and 12 weeks of gestation in women less than 35 years of age is 9% to 12%. The risk increases with age. In women older than 40 years of age, the sporadic miscarriage rate approaches 50%. Late losses between 12 and 22 weeks occur less frequently and constitute around 4% of pregnancy outcomes [4,9].Compared to sporadic miscarriage the prevalence of RM is considerably lower irrespective of whether biochemical losses are included or not. Approximately 1% of all women trying to conceive have recurrent miscarriage, defined as three previous miscarriages; when recurrent miscarriage is defined as two previous miscarriages, the proportion rises to 3% [12,13]. EtiologyMultiple potential etiologies for RM have been described (Table 1). As a consequence, several recommendations have been published regarding the evaluation and management of RM [3].The potential etiologies of RM can be divided into embryologically driven causes (mainly due to an abnormal embryonic karyotype) and maternally driven causes which affect the endometrium and/or placental development [14,15]. Thus, studies that focus on RM have Barrenetxea G, et al., J Reprod Med Gynecol Obstet 2017 AbstractHuman reproduction is characterized by its inefficiency. The loss of pregnancy at any stage can be a devastating experience and particular sensitivity is required in assessing and counseling couples with Recurrent Miscarriage (RM). Recurrent Miscarriage (RM) represents a clinical challenge for physicians not only because there are multiple possible etiologies, but also because the diagnostic testing is costly and time consuming. Despite several well-known etiologic factors, the cause of RM cannot be determined in almost 50% of cases. Multiple potential etiolo...

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“…Genetic material in embryo derived from unbalanced sperm would be excessive or insufficient, leading to partial trisome or monosome, and therefore result in obstacle in embryo development and showing biochemical pregnancy or early miscarriage [11,12]. What is meaningful about this case is that, the comparison between the outcomes of ICSI cycles with sperm from two men with different chromosome type provided a much stronger evidence to show the impact of translocation on embryo development.…”

Section: Discussionmentioning

confidence: 94%

Impact of reciprocal translocation t (18; 21) on male infertility and embryo development: lessons from an oocyte-donating ICSI cycle

Zhang

Zhu

2011

J Assist Reprod Genet

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Purpose To report the outcome of intracytoplasmic sperm injection (ICSI) cycles of an oligozoospermic man with reciprocal translocation. Methods Two ICSI cycles were given to a 29-year-old man with severe oligozoospermia and reciprocal translocation t (18;21)(p11;q21) and his wife. In the first cycle, no sperm were found in his semen and all 15 oocytes retrieved were donated to another infertile couple suffering from oligozoospermia and premature ovarian failure. In the second cycle, sperm from the husband's ejaculate were used to fertilize 13 retrieved oocytes. Results Eleven embryos were acquired and a healthy girl was born in the oocyte-donated ICSI cycle. In the second cycle, 6 embryos were acquired and only biochemical pregnancy was achieved after three times of embryo transfer. Conclusions By the unusual oocyte-donating ICSI procedures, impact of the new reported reciprocal translocation t (18; 21) (p11; q21) on male fertility and embryo development was suggested.

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Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss

Cited by 39 publications

References 11 publications

Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of chromosome abnormalities or polymorphisms

Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of chromosome abnormalities or polymorphisms

Recurrent Miscarriage: A Review

Impact of reciprocal translocation t (18; 21) on male infertility and embryo development: lessons from an oocyte-donating ICSI cycle

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