Pregnancy-Associated Thrombocytopenia: Definition, Incidence and Natural History

Matthews, Jacqueline; Benjamin, Santosh; Gill, Denis; Smith, NC

doi:10.1159/000205022

Cited by 76 publications

(52 citation statements)

References 14 publications

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“…Thus, the prevalence of thrombocytopenia in Indian population is similar to world literature (5-12%). The present study found no influence of age and religion on prevalence of thrombocytopenia in pregnancy similar to Mathews et al [6]. 96.3% of controls and 95.7% of cases were enrolled in third trimester since most antenatal women in our population seek advice in late pregnancy or when a complication arises.…”

Section: Discussionsupporting

confidence: 88%

Prevalence and Characterization of Thrombocytopenia in Pregnancy in Indian Women

Singh

Dhakad

Uma

et al. 2011

Indian J Hematol Blood Transfus

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To find the prevalence and causes of thrombocytopenia during pregnancy. An analytical prospective observational study was conducted in Department of Obstetrics & Gynecology, CSMMU, Lucknow. 1079 antenatal women screened for thrombocytopenia and investigated for cause and management strategies and fetomaternal outcome were recorded. Prevalence of thrombocytopenia was 8.8%. Gestational thrombocytopenia was seen in 64.2%, obstetric in 22.1% and medical in 13.68% cases. Mean platelet count in controls was lower with a significant fall (P \ 0.001) in the platelet count as pregnancy advanced. Hypertensive and hepatic disorders were the most common obstetric causes of thrombocytopenia. Mode of delivery was not affected by thrombocytopenia. Maternal morbidity and mortality was seen only in medical and obstetric thrombocytopenia. The low platelet counts and declining trend with increasing gestational age predispose Indian women to risk of thrombocytopenia and a routine platelet count is suggested.

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Section: Discussionsupporting

confidence: 88%

Prevalence and Characterization of Thrombocytopenia in Pregnancy in Indian Women

Singh

Dhakad

Uma

et al. 2011

Indian J Hematol Blood Transfus

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“…This figure was higher than figures of 11.6% reported by Boehlen et al in and 7.2% reported by Sainio et al 2,3 The higher prevalence in this study may be because of malaria and dengue infections. The present study found no influence of age and religion on prevalence of thrombocytopenia in pregnancy like Mathews et al 10 From our findings, gestational thrombocytopenia occurred across the three trimesters. No case of severe thrombocytopenia was seen in first trimester.…”

Section: Discussioncontrasting

confidence: 57%

Thrombocytopenia during pregnancy: an institutional based prospective study of one year

Pandey¹,

Singh²

2017

Int J Res Med Sci

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Background: Platelets are non-nucleated cellular fragments of megakaryocytes, they play a critical role in haemostasis. Thrombocytopenia, defined as blood platelet count below 150.000/μL is the second leading cause of blood disorders in pregnancy after anemia. It complicates 7 to 10% of all pregnancies. Gestational thrombocytopenia explains 70-80% of all cases of thrombocytopenia in pregnancy. Hypertensive disorders account for approximately 20% and immune thrombocytopenic purpura for about 3-4%. Other etiologies are considered rare in pregnancy.Methods: The study was conducted in the tertiary institute over a period of one year, from January 2016 to December 2016. The samples of blood were collected from the Antenatal out-patient department and from indoor patients of the department of gynecology and obstetrics of the J.K. Hospital, Bhopal, Madhya Pradesh India.Results: Maximum number of patients had moderate degree of anemia around 58%. Most of the cases presented during 30-34 weeks of gestation. The most common etiology was gestational thrombocytopenia.Conclusions: Thrombocytopenia in pregnancy may occur secondary to a variety of causes. Most of these cases occur during specific periods of gestation. Management of pregnant women with platelet disorders requires a multidisciplinary approach and close collaboration between obstetric and hepatologist.

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“…Increased blood volume, increased platelet activation, and increased platelet clearance contribute to a 'physiologic' decrease in platelet count during pregnancy [4]. Gestational thrombocytopenia is considered to be the most prevalent cause of thrombocytopenia in pregnancy and accounts for about 75% of cases its cases during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Fetal-maternal complications and their association with gestational thrombocytopenia

Elveđi-Gašparović

Beljan²,

Gverić-Ahmetašević³

et al. 2016

Ginekol Pol

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Objectives: Thrombocytopenia is defined as a platelet count of < 150 × 10 9 /L. It is a common hematologic abnormality during pregnancy. Evaluation and treatment of gestational thrombocytopenia can be both, expensive and invasive, and may result in an adverse outcome. The aim of our study was to investigate the incidence of perinatal complications in pregnancies complicated with gestational thrombocytopenia and to determine if the severity of maternal gestational thrombocytopenia implicates unfavorable perinatal outcome. Material and methods:Over a period of three years, we identified 50 patients with gestational thrombocytopenia: 38 with platelet count between 50-100 × 10 9 /L -classified as moderate thrombocytopenia, and 12 with platelet count of < 50 × 10 9 /L -classified as severe thrombocytopenia. Fifty women with normal platelet count constituted the control group. Maternal complications and neonatal outcomes were compared. Results:Neonatal thrombocytopenia occurred more often in pregnancies complicated with gestational thrombocytopenia (p = 0.041). Thrombocytopenia in previous pregnancy seems to be an important predicting factor for disease severity in the current pregnancy (p = 0.01). Conclusions:Gestational thrombocytopenia, even if severe, is not associated with adverse maternal or neonatal outcome. Moderate neonatal thrombocytopenia is more common in pregnancies complicated with severe gestational thrombocytopenia. The incidence of severe gestational thrombocytopenia is higher in patients with thrombocytopenia in previous pregnancy.

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Pregnancy-Associated Thrombocytopenia: Definition, Incidence and Natural History

Cited by 76 publications

References 14 publications

Prevalence and Characterization of Thrombocytopenia in Pregnancy in Indian Women

Prevalence and Characterization of Thrombocytopenia in Pregnancy in Indian Women

Thrombocytopenia during pregnancy: an institutional based prospective study of one year

Fetal-maternal complications and their association with gestational thrombocytopenia

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