Pregnancies diagnosed during Depo-Provera use

Drugs in infertility and fetal safety

“…Although a few investigators reported an association between progesterone treatment and hypospadias, its relationship with the widely used ''natural'' micronized progesterone is unlikely. In a study of inadvertent use of depot medroxyprogesterone acetate during pregnancy, no fetal malformation was reported (63).…”

Depo Now: Preventing Unintended Pregnancies among Adolescents and Young Adults

“…Clinical concerns about the failure of a urine pregnancy test to detect a window pregnancy and the need to return for a follow-up visit must be discussed with each patient and include information about the possible, but unproven [11], effects of DMPA on the developing fetus. The difficulties we experienced having women return for this 21-day visit are not unique.…”

Ectopic pregnancy with use of progestin-only injectables and contraceptive implants: a systematic review

“…The ectopic pregnancy occurred approximately 40 days after the second injection in a woman with a history of PID. Finally, four ectopic pregnancies were reported among 949,182 users of 150-mg im DMPA in a review of Planned Parenthood Federation of America insurance data collected between 1994 and 1998 [82]. The pregnancy data from this review are incomplete, however, as site of implantation is only documented for 37% of clients between 1997 and 1998 compared to almost 98% of clients between 1994 and 1995, and the review does not report when the four ectopic pregnancies occurred.…”

“…While we cannot be certain that this is the case, the fact that only six reports of ectopic pregnancy in three studies exist in nearly 50 years of published literature on progestin injectables supports such an assumption. Furthermore, each of the three injectable studies that report ectopic pregnancy have important limitations, including incomplete data [82], use of very low dose of progestin [93] and a confounding risk factor for ectopic pregnancy [85].…”