Pregabalin: a new anxiolytic

Lauria-Horner, Bianca; Pohl, Robert

doi:10.1517/13543784.12.4.663

Cited by 302 publications

(38 citation statements)

References 41 publications

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“…10,17 When studied in non-humans pregabalin appears to be 3 to 10 times more potent as an anticonvulsant than gabapentin. 18,19 Pregabalin is 2 to 4 times more potent as an analgesic than gabapentin. 18,19 Pregabalin is 6 times more potent than gabapentin in binding affinity.…”

Section: 6mentioning

confidence: 99%

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Comparative efficacious study between preoperative pregabalin and gabapentin on postoperative pain in abdominal hysterectomy: an institutional experience

Gayathri¹,

Swaroop²,

G³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Pain is a consistent and predominant complaint following surgical intervention including abdominal open hysterectomy. A multimodal approach has been suggested to improve postoperative analgesia and to reduce opioid related side effects. In this context we conducted a comparative study on efficacy between gabapentin and pregabalin on postoperative pain relief.Methods: In this prospective randomised study, 60 patients were divided in to two arms group G and group P. 900 mg of gabapentin and 300 mg of pregabalin were administered orally one hour before spinal anaesthesia to respective groups. Hemodynamic parameters such as heart rate, mean arterial pressure, respiratory rate was monitored pre, per and postoperatively. Also, the need for first analgesic dose and visual analog pain score were documented in all subjects of both groups. Statistical analysis with SPSS 16.0 performed.Results: There was significant fall in mean arterial pressure in group G than group P patients. Further the fall in mean pulse rate was more in group G compared to group P throughout pre, per and post-operative phases. In terms of mean postoperative time required for first dose of analgesic drug, pregabalin and gabapentin was required after 7 and 5 hours respectively. There was a statistically significant change in Visual Analogue Scale, showing pregabalin as better drug than gabapentin in post operative pain control with score 5 and 7 respectively.Conclusions: Pre-emptive analgesia with pregabalin appears to be superior to gabapentin as a part of multimodal perioperative pain management in abdominal hysterectomy.

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Section: 6mentioning

confidence: 99%

“…18,19 Pregabalin is 2 to 4 times more potent as an analgesic than gabapentin. 18,19 Pregabalin is 6 times more potent than gabapentin in binding affinity. 20 We choose 900 mg of gabapentin to 300mg of pregabalin.…”

Section: 6mentioning

confidence: 99%

Comparative efficacious study between preoperative pregabalin and gabapentin on postoperative pain in abdominal hysterectomy: an institutional experience

Gayathri¹,

Swaroop²,

G³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…This is prompted by multiple reports involving gabapentin, pregabalin and tiagabin among others. 53,54 While these medications are less dependency forming than benzodiazepines they are also less effective. Some newer agents such as pregabaline seem to have more antianxiety properties, but this remains to be documented in large controlled clinical trials.…”

Section: Pharmacologicalmentioning

confidence: 99%

Treatment-resistant anxiety disorders

2006

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Several epidemiological studies confirmed that Anxiety Disorders as a group are the most prevalent psychiatric conditions in the United States. The importance of these conditions is underlined by the fact that they cause significant disability, poor quality of life, alcohol and drug abuse. Anxiety disorders are treatable conditions and respond to the front-line interventions such as serotonin reuptake inhibitors and cognitive behavioral therapy. However, only about 60% of patients respond to those treatments to any significant degree. Many still have residual symptoms or stay treatment refractory. The group of anxiety patients that is resistant to the treatment has been shown to have very poor quality of life and have highest rate of suicidal attempts than any other disorders. Many biological, treatment specific and social factors are affecting treatment resistance. In this paper, we are attempting to review reasons for the treatment resistance. In addition, we would like to review current strategies that could be helpful in reducing treatment resistance and aiding people chronically suffering from these severe and disabling conditions.

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“…3 It has also got anxiolytic property. 11,12 Pregabalin has been recommended in a dose 75 mg to 600 mg/day for treatment of epilepsy and central neuropathic pain. It has linear pharmacokinetic profile across the therapeutic range with fewer side effects, most common being dizziness and somnolence, having no effect on arterial pressure or heart rate.…”

Section: Discussionmentioning

confidence: 99%