Prefrontal serotonin depletion impairs egocentric, but not allocentric working memory in rats

González-Burgos, Ignacio; Fletes-Vargas, Gabriela; González-Tapia, David; González-Ramírez, Myrna M.; Rivera-Cervantes, M.C.; Martínez-Degollado, Martha

doi:10.1016/j.neures.2012.05.003

Cited by 13 publications

(10 citation statements)

References 75 publications

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“…Previous studies suggested a fronto-parietal network to subserve the computation of allocentric and egocentric reference frames (Galati et al, 2000;Zaehle et al, 2007) with prefrontal areas and the ACC subserving diverse navigation-related functions such as working memory, attention, and route planning (Spiers and Maguire, 2006;Simons et al, 2008;González-Burgos et al, 2012). In the present study, a cluster in or near the ACC revealed significant theta band synchronization reflecting spatial working memory demands to compute and maintain participants' spatial representation for successful path integration.…”

Section: Discussionsupporting

confidence: 57%

EEG correlates of spatial orientation in the human retrosplenial complex

2015

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Studies on spatial navigation reliably demonstrate that the retrosplenial complex (RSC) plays a pivotal role for allocentric spatial information processing by transforming egocentric and allocentric spatial information into the respective other spatial reference frame (SRF). While more and more imaging studies investigate the role of the RSC in spatial tasks, high temporal resolution measures such as electroencephalography (EEG) are missing. To investigate the function of the RSC in spatial navigation with high temporal resolution we used EEG to analyze spectral perturbations during navigation based on allocentric and egocentric SRF. Participants performed a path integration task in a clearly structured virtual environment providing allothetic information. Continuous EEG recordings were decomposed by independent component analysis (ICA) with subsequent source reconstruction of independent time source series using equivalent dipole modeling. Time-frequency transformation was used to investigate reference frame-specific orientation processes during navigation as compared to a control condition with identical visual input but no orientation task. Our results demonstrate that navigation based on an egocentric reference frame recruited a network including the parietal, motor, and occipital cortices with dominant perturbations in the alpha band and theta modulation in frontal cortex. Allocentric navigation was accompanied by performance-related desynchronization of the 8-13 Hz frequency band and synchronization in the 12-14 Hz band in the RSC. The results support the claim that the retrosplenial complex is central to translating egocentric spatial information into allocentric reference frames. Modulations in different frequencies with different time courses in the RSC further provide first evidence of two distinct neural processes reflecting translation of spatial information based on distinct reference frames and the computation of heading changes.

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Section: Discussionsupporting

confidence: 57%

EEG correlates of spatial orientation in the human retrosplenial complex

2015

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“…Specifically, individuals with at least one low or long G allele used more a third person perspective in episodic memory, facilitating the storing of an allocentric memory of their body. More, the results of the study by Gonzalez-Burgos et al (2012) showed that serotonin depletion impaired the egocentric working memory performance while no effects were found for the allocentric one.…”

Section: The Role Of 5-ht Systems In the Allocentric Lockmentioning

confidence: 96%

“…In another animal study, Gonzalez-Burgos et al (2012) explored the effects of prefrontal serotonin depletion on the memory strategies (allocentric and egocentric) used in a working memory task. The results suggested that serotonin may be involved in the prefrontal organization of egocentric working memory, based on own movement-guided responses.…”

Section: The Role Of 5-ht In Working Spatial and Episodic Memorymentioning

confidence: 99%

Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory

Riva

2016

Front. Hum. Neurosci.

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The etiology of anorexia nervosa (AN) is still unclear, despite that it is a critical and potentially mortal illness. A recent neurobiological model considers AN as the outcome of dysfunctions in the neuronal processes related to appetite and emotionality (Kaye et al., 2009, 2013). However, this model still is not able to answer a critical question: What is behind body image disturbances (BIDs) in AN? The article starts its analysis from reviewing some of the studies exploring the effects of the serotonin systems in memory (episodic, working, and spatial) and its dysfunctions. The review suggests that serotonin disturbances may: (a) facilitate the encoding of third person (allocentric) episodic memories; (b) facilitate the consolidation of emotional episodic memories (e.g., teasing), if preceded by repeated stress; (c) reduce voluntary inhibition of mnestic contents; (d) impair allocentric spatial memory. If we discuss these results within the interpretative frame suggested by the “Allocentric Lock Hypothesis” (Riva, 2012, 2014), we can hypothesize that altered serotoninergic activity in AN patients: (i) improves their ability to store and consolidate negative autobiographical memories, including those of their body, in allocentric perspective; (ii) impairs their ability to trigger voluntary inhibition of the previously stored negative memory of the body; (iii) impairs their capacity to retrieve/update allocentric information. Taken together, these points suggest a possible link between serotonin dysfunctions, memory impairments and BIDs: the impossibility of updating a disturbed body memory using real time experiential data—I'm locked to a wrong body stored in long term memory—pushes AN patients to control body weight and shape even when underweight.

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“…The reduction in 5‐HT in the rat brain affected egocentric, but not allocentric, related behavioral performance. This finding suggests that 5‐HT could be more closely associated with the organization of working memory, which uses its own movement‐guided answers, than outward visuospatial cues (Gonzales‐Burgos et al, ). In our previous study, learning and spatial memory improvement was associated with a reduction in cortical 5‐HT and DA levels.…”

Section: Discussionmentioning

confidence: 99%

Passiflora incarnata L. Improves Spatial Memory, Reduces Stress, and Affects Neurotransmission in Rats

Jawna-Zboińska

Blecharz-Klin

Joniec-Maciejak

et al. 2016

Phytotherapy Research

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Passiflora incarnata L. has been used as a medicinal plant in South America and Europe since the 16th century. Previous pharmacological studies focused mainly on the plant's sedative, anxiolytic, and anticonvulsant effects on the central nervous system and its supporting role in the treatment of addiction. The aim of the present study was to evaluate the behavioral and neurochemical effects of long-term oral administration of P. incarnata. The passionflower extract (30, 100, or 300 mg/kg body weight/day) was given to 4-week-old male Wistar rats via their drinking water. Tests were conducted after 7 weeks of treatment. Spatial memory was assessed in a water maze, and the levels of amino acids, monoamines, and their metabolites were evaluated in select brain regions by high performance liquid chromatography (HPLC). We observed reduced anxiety and dose-dependent improvement of memory in rats given passionflower compared to the control group. In addition, hippocampal glutamic acid and cortical serotonin content were depleted, with increased levels of metabolites and increased turnover. Thus, our results partially confirmed the proposed mechanism of action of P. incarnata involving GABAA receptors. Copyright © 2016 John Wiley & Sons, Ltd.

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Prefrontal serotonin depletion impairs egocentric, but not allocentric working memory in rats

Cited by 13 publications

References 75 publications

EEG correlates of spatial orientation in the human retrosplenial complex

EEG correlates of spatial orientation in the human retrosplenial complex

Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory

Passiflora incarnata L. Improves Spatial Memory, Reduces Stress, and Affects Neurotransmission in Rats

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