Abstract:Pyramidal neurons located within layer V of the medial prefrontal cortex drive cognitive circuits by integrating afferent signals and sending efferent projections to cortical and subcortical targets. This role is supported by cholinergic neurotransmission, which modulates pyramidal neuron excitability via postsynaptic nicotinic receptors. We employed whole-cell electrophysiology with neuron reconstruction in brain slices from mice of both sexes to demonstrate that medial prefrontal layer V pyramidal neurons co… Show more
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