Preferentially Disrupted Core Hubs Within the Default-Mode Network in Patients With End-Stage Renal Disease: A Resting-State Functional Magnetic Resonance Imaging Study

Ma, Chi; Tian, Fen; Ma, Minge; Su, Hua-Wei; Fan, Jiancong; Li, Zhanhui; Ren, Yande

doi:10.3389/fneur.2020.01032

Cited by 8 publications

(8 citation statements)

References 61 publications

(81 reference statements)

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“…Because of the renal failure, the serum creatinine and urea levels were significantly increased in patients with ESRD. Previous researchers have found that the serum creatinine and urea levels were correlated with altered spontaneous brain activity and functional integration ( 15 , 25 , 39 , 40 ). However, in our study, serum creatinine and urea levels showed no correlation with ALFF values or Z scores of abnormal FC in the brain regions.…”

Section: Discussionmentioning

confidence: 98%

Altered Spontaneous Brain Activity and Functional Integration in Hemodialysis Patients With End-Stage Renal Disease

Liu

et al. 2022

Front. Neurol.

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PurposeUsing the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) algorithm to study the alteration of brain function in hemodialysis patients with end-stage renal disease (ESRD).Patients and MethodsWe recruited 20 patients with ESRD on regular hemodialysis and 17 healthy controls (HCs). All of the participants underwent resting-state fMRI (rs-fMRI), neuropsychological tests, and blood biochemical examination. The individual ALFF values between the two groups were tested by an independent sample t-test. Then, we set the altered ALFF brain areas as seed regions of interest (ROIs), and FC analysis was used to investigate the functional integration patterns between the seed ROI and the voxels within the whole brain.ResultsThe ALFF values of the right precuneus and angular gyrus (RAG) in the ESRD group were lower than those in the HC subjects, but the right precentral gyrus showed higher ALFF values in patients. Hemoglobin (Hb) was negatively correlated with the ALFF values of the right precentral gyrus, and the ALFF values of the right precuneus were negatively correlated with line-tracing test (LTT) scores in patients with ESRD. Patients with ESRD show decreased connectivity between the RAG and the left precuneus, right superior frontal gyrus (RSFG), and the connectivity within the RAG was weak. In addition, FC in the RAG-right cuneus, right precuneus-left supramarginal gyrus was enhanced in the patient group.ConclusionOur research suggested that, in hemodialysis patients with ESRD, the brain areas with abnormal spontaneous brain activity and FC are mainly located in the default mode network (DMN) regions. Hb and the LTT results were correlated with abnormal spontaneous brain activity. These findings provide additional evidence to understand the possible underlying neuropathological mechanisms in patients with ESRD.

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Section: Discussionmentioning

confidence: 98%

Altered Spontaneous Brain Activity and Functional Integration in Hemodialysis Patients With End-Stage Renal Disease

Liu

et al. 2022

Front. Neurol.

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“…A number of previous rs-fMRI studies have also con rmed that ESRD patients showed altered ReHo, ALFF values and FC in the DMN region, which was consistent with the results of this study. The results indicated that decreased synchronization of activity in the DMN region may be the neuropathological mechanism of overall cognitive impairment in patients with ESRD [30][31][32][33].…”

Section: Discussionmentioning

confidence: 92%

Altered spontaneous brain activity and functional connectivity in patients with end-stage renal disease

Bai

Wang

et al. 2022

Preprint

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Background: Neurological complications occurs frequently in patients with end-stage renal disease (ESRD), the neuropathological mechanisms of which remains unclear. This study investigated changes in local neuronal functional activity in ESRD patients using regional homogeneity (ReHo) and functional connectivity (FC) algorithms based on resting-state functional magnetic resonance imaging (rs-fMRI) and analysed associations between spontaneous brain activity changes and blood biochemical indices. Methods: Thirty-six patients with ESRD and Thirty-two healthy controls were scanned with rs-fMRI to calculate ReHo values across the whole brain. Brain areas with altered ReHo values were selected as regions of interest (ROIs) for FC analysis, which was used to explore the functional integration between ROIs. Independent sample t tests were used for comparison between groups, and Pearson’s correlation analyses were used for the correlation between altered ReHo values and clinical data. Results: Compared with the healthy controls, ESRD patients showed increased ReHo in the left temporal pole (TPO), right orbital inferior frontal gyrus (ORBinf) and bilateral rectus gyrus (REC) (P<0.01, AlphaSim corrected), while the ReHo values in the bilateral calcarine sulcus (CAL), left inferior frontal gyrus (IFG), right superior temporal gyrus (STG) and supramarginal gyrus (SMG) were significantly decreased (P<0.01). ESRD patients showed decreased FC between the right CAL and both the left IFG and right SMG (P<0.01). We also found decreased FC between the right SMG and right STG. Correlation analyses showed that ReHo values in the right CAL were positively correlated with haemoglobin levels (r=0.347, P=0.048) and haematocrit (r=0.357, P=0.041). Conclusion: ESRD patients had dyssynchrony in local functional activities in several brain regions, mainly involving the default mode network (DMN), and dyssynchrony in local and remote brain activities in the IFG-CAL-SMG-STG circuit, which may contribute to further understanding of the neuropathological mechanism of brain injury in patients with ESRD.

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“…These functional impairments of the DMN regions may influence the normal interactions between DMN subnetworks. Indeed, a recent study did demonstrate that patients with ESRD exhibit significantly lower FC between the two DMN hubs (i.e., the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex) and between the two DMN subnetworks (i.e., the dorsal medial prefrontal cortex subnetwork and the medial temporal lobe subnetwork) compared to HCs ( Ma et al, 2020 ). Evidences from these studies suggest functional deficits of the DMN regions and abnormal functional interactions of the DMN subnetworks, and thus support our findings.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease

Yan

Zheng

et al. 2022

Front. Neurosci.

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Dynamic functional connectivity (FC) analysis can capture time-varying properties of connectivity; however, studies focusing on dynamic FC in patients with end-stage renal disease (ESRD) are very limited. This is the first study to explore the dynamic aspects of whole-brain FC and topological properties in ESRD patients. Resting-state functional magnetic resonance imaging data were acquired from 100 ESRD patients [50 hemodialysis (HD) patients and 50 non-dialysis patients] and 64 healthy controls (HCs). Independent component analysis, a sliding-window approach and graph-theory methods were used to study the dynamic FC properties. The intrinsic brain FC were clustered into four configuration states. Compared with HCs, both patient groups spent longer time in State 3, in which decreased FC between subnetworks of the default mode network (DMN) and between the dorsal DMN and language network was observed in these patients, and a further reduction in FC between the DMN subnetworks was found in HD patients compared to non-dialysis patients. The number of transitions and the variability of global and local efficiency progressively decreased from that in HCs to that of non-dialysis patients to that of HD patients. The completion time of Trail Making Test A and Trail Making Test B positively correlated with the mean dwell time of State 3 and negatively correlated with the number of transitions in ESRD patients. Our findings suggest impaired functional flexibility of network connections and state-specific FC disruptions in patients with ESRD, which may underlie their cognitive deficits. HD may have an adverse effect on time-varying FC.

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Preferentially Disrupted Core Hubs Within the Default-Mode Network in Patients With End-Stage Renal Disease: A Resting-State Functional Magnetic Resonance Imaging Study

Cited by 8 publications

References 61 publications

Altered Spontaneous Brain Activity and Functional Integration in Hemodialysis Patients With End-Stage Renal Disease

Altered Spontaneous Brain Activity and Functional Integration in Hemodialysis Patients With End-Stage Renal Disease

Altered spontaneous brain activity and functional connectivity in patients with end-stage renal disease

Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease

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