1996
DOI: 10.1046/j.1471-4159.1996.67052180.x
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Abstract: The release of adenosine and ATP evoked by electrical field stimulation in rat hippocampal slices was investigated with the following two patterns of stimulation: (1) a brief, high-frequency burst stimulation (trains of stimuli at 100 Hz for 50 ms applied every 2 s for 1 mm), to mimic a long-term potentiation (LTP) stimulation paradigm, and (2) a more prolonged (3 mm) and lowfrequency (5 Hz) train stimulation, to mimic a long-term depression (LTD) stimulation paradigm. The release of ATP was greater at a brief… Show more

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Cited by 232 publications
(227 citation statements)
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“…Note that in purified nerve terminals, which only account for 1%Y2% of the volume of more integrated preparations [129], spatial restrains are decreased and it is the only preparation where it has been demonstrated that ecto-5 0 -nucleotidase was the predominant enzymatic activity responsible for the formation of extracellular adenosine from adenine nucleotides [130]. Thus, in nerve terminals, a,b-methylene ADP is able to decrease the formation of extracellular adenosine [107,108,112,117,118].…”
Section: Generation Of Extracellular Adenosinementioning
confidence: 99%
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“…Note that in purified nerve terminals, which only account for 1%Y2% of the volume of more integrated preparations [129], spatial restrains are decreased and it is the only preparation where it has been demonstrated that ecto-5 0 -nucleotidase was the predominant enzymatic activity responsible for the formation of extracellular adenosine from adenine nucleotides [130]. Thus, in nerve terminals, a,b-methylene ADP is able to decrease the formation of extracellular adenosine [107,108,112,117,118].…”
Section: Generation Of Extracellular Adenosinementioning
confidence: 99%
“…Thus, ATP is stored in synaptic vesicles and nerve terminals release ATP on stimulation (reviewed in [110]). This release of ATP is larger the higher the frequency of nerve stimulation [111,112] and the contribution of ATP-derived adenosine increases with increasing frequencies of nerve stimulation [112,113]. In contrast, the contribution of adenosine released as such through equilibrative nucleoside transporters predominates at lower frequencies of nerve stimulation ( [112]; see also [114]).…”
Section: Generation Of Extracellular Adenosinementioning
confidence: 99%
See 1 more Smart Citation
“…Thus, stimulated nerve terminals can synaptically release ATP. This occurs preferentially at high frequency stimulation (Cunha et al, 1996b), and extracellular degradation of synaptically released ATP to adenosine is not associated with the activation of inhibitory A 1 , but with activation of facilitatory A 2A receptors (Cunha et al, 1996a). Synaptic activation of A 2A receptors can subsequently downregulate A 1 receptors or its responses (Ciruela et al, 2006;Lopes et al, 1999).…”
Section: Adenosine a 2a Receptorsmentioning
confidence: 99%
“…The presynaptic release of ATP and its extracellular conversion to adenosine has important consequences for the modulation of synaptic transmission. Thus, ATP was preferentially released (and subsequently degraded to adenosine) upon high-frequency stimulation of hippocampal slices (Cunha et al, 1996b) leading to the preferential activation of excitatory A 2A receptors (Cunha et al, 1996a); this mechanism allows the selective potentiation of high frequency bursts within a tonically inhibited network.…”
Section: Presynaptic Vesicular Release Of Atpmentioning
confidence: 99%