Preferential Localization of Antibody Combinations in Tumor Xenografts in Nude Mice1

Hinkle, George H.; Houchens, David P.; Miller, Elizabeth R.; Nines, Ron; Nabi, Hani A.; Thurston, M.O.; Tuttle, Steven E.; Mojzisik, Cathy; Martin, Edward N.

doi:10.1159/000413332

Cited by 2 publications

(1 citation statement)

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“…Such lower energy gamma photons were more likely to be detected because the radiation was less likely to pass through a small detector without being counted. Likewise, in tumor-bearing mice, higher tumor-to-background ratios were achievable with 125 I labeled antibodies than with 131 I labeled antibodies [ 293 ]. This resultant improved tumor-to-background ratio was a function of greater tissue attenuation and lesser scatter that occurs because of the lower energy gamma photon emission of 125 I [ 8 , 26 ].…”

Section: Clinical Applications (Table 2 )mentioning

confidence: 99%

A comprehensive overview of radioguided surgery using gamma detection probe technology

et al. 2009

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The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and realtime information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology.

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Section: Clinical Applications (Table 2 )mentioning

confidence: 99%